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| 1 | Effects of nonalcoholic fatty liver disease on the development of metabolic disorders显示文摘 | Fan, JG Li, F Cai, XB Peng, YD Ao, QH Gao, Y | 2007 | 中国生物学文摘2007，21，11： | 51 |
| 2 | Outcomes of furazolidone-and amoxicillin-based quadruple therapy for Helicobacter pylori infection and predictors of failed eradication显示文摘AIM To evaluate the outcomes of furazolidone-and amoxicillin-based quadruple therapy for treatment of Helicobacter pylori(H. pylori) infection and identify predictors of failed eradication.METHODS Patients with H. pylori infection treated with furazolidone, amoxicillin, bismuth, and proton pump inhibitor therapy(January 2015 to December 2015) who received the ^(13)C-urea breath test > 4 wk after treatment were evaluated. Demographic and clinical data including prior H. pylori treatment attempts, medication adherence, alcohol and cigarette consumption during therapy, and treatment-related adverse events were recorded by reviewing medical records and telephone surveys. H. pylori eradication rates for overall and subgroups were evaluated. Multivariate analysis was performed to identify independent predictors of failed H. pylori eradication.RESULTS Of the 992 patients treated and retested for H. pylori infection, the overall eradication rate was 94.5% [95% confidence interval(CI): 94.1%-95.9%]. H. pylori eradication rate of primary therapy was 95.0%(95%CI: 93.5%-96.5%), while that of rescue therapy was 91.3%(95%CI: 86.8%-95.8%). Among the 859 patients who completed the study protocol, 144(17%) reported treatment-related adverse events including 24(3%) leading to premature discontinuation. On multivariate analysis, poor medication adherence [adjusted odds ratio(AOR) = 6.7, 95%CI: 2.8-15.8], two or more previous H. pylori treatments(AOR = 7.4, 95%CI: 2.2-24.9), alcohol consumption during therapy(AOR = 4.4, 95%CI: 1.5-12.3), and possibly smoking during therapy(AOR = 1.9, 95%CI: 0.9-4.3) were associated with failed H. pylori eradication. CONCLUSION Furazolidone-and amoxicillin-based quadruple therapy for H. pylori infection in an area with a high prevalence of clarithromycin resistance demonstrated high eradication rates as primary and rescue therapies with a favorable safety profile. Patient education targeting abstinence from alcohol during therapy and strict medication adherence may further optimize H. pylori eradication. | Ya-Wen Zhang Wei-Ling Hu Yuan Cai Wen-Fang Zheng Qin Du John J Kim John Y Kao Ning Dai Jian-Min Si | 2018 | World Journal of Gastroenterology2018，24，40： | 18 |
| 3 | Generalized crack initiation and crack damage stress thresholds of brittle rock masses near underground excavations显示文摘 | M Cai P.K Kaiser Y Tasaka T Maejima H Morioka M Minami | 2004 | International Journal of Rock Mechanics and Mining Sciences2004，，5： | 9 |
| 4 | 相对骨骼肌质量与非酒精性脂肪性肝病的关系:一项系统评价和荟萃分析显示文摘【据《Hepatol Int》2020年1月报道】题:相对骨骼肌质量与非酒精性脂肪性肝病的关系:一项系统评价和荟萃分析(作者Cai C等)非酒精性脂肪性肝病(NAFLD)已逐渐成为全世界最常见的慢性肝病之一。越来越多的证据表明,低骨骼肌质量指数(SMI)可能在NAFLD的发展中起作用。该研究目的是探讨量化SMI、肌少症与NAFLD发生和发展之间的关联。作者系统地检索了PubMed、Embase、Web of Science和Cochrane图书馆中相关的英语研究,时间截止至2018年12月20日。 | 蔡昌洲 虞朝辉 CAI C SONG X CHEN Y | 2020 | 临床肝胆病杂志2020，36，3： | 7 |
| 5 | Regulation of Nrf2- and AP-l-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells显示文摘 | Sujit NAIR Avantika BARVE Tin-Oo KHOR Guo-xiang SHEN Wen LIN Jefferson Y CHAN Li CAI Ah-Ng KONG | 2010 | Acta Pharmacologica Sinica2010，31，9： | 5 |
| 6 | Generalized crack initiation and crack damage stress thresholds of brittle rock masses near underground excavations显示文摘 | M Cai P.K Kaiser Y Tasaka T Maejima H Morioka M Minami | 2004 | International Journal of Rock Mechanics and Mining Sciences2004，，5： | 3 |
| 7 | Advanced proportional-integralderivative tuning for integrating and unstable processes with gain and phase margin specifications 显示文摘 | Wang Y G Cai W J | 2002 | Ind Eng Chem Res2002，41，12： | 2 |
| 8 | Study on mechanism of ceramics grinding显示文摘 | Kitajima K Cai G Q Kumagai N Tanaka Y Zheng H W | 1992 | Annals of the CIRP1992，41，1： | 2 |
| 9 | Microstructure and Je improvements in overpressure processed Agsheathed Bi-2223 tapes显示文摘 | Yuan Y Jiang J Cai X Y | 2003 | IEEE Trans Appl Supercond2003，13，： | 2 |
| 10 | 显示文摘 | Cai L Mahmound H Han Y | 1999 | Tetrahedron: Asymmetry1999，10，3： | 2 |
| 11 | 土壤微生物生态学研究方法进展显示文摘 | Cai Y F Liao Z W | | 土壤与环境0，，： | 2 |
| 12 | Molecular alterations of p73 in human esophageal squamous cell carcinomas:loss of heterozygosity occurs frequently;loss of imprinting and elevation of p73 expression may be related to defective p53显示文摘 | Cai YC Yang GY Nie Y | | 0，，： | 2 |
| 13 | Convergence of a multiscale finite element method for elliptic problems with rapidly oscillating coefficients显示文摘 | Hou T Y Wu X H Cai Z | 1999 | Mathematics of Computation1999，68，227： | 2 |
| 14 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 15 | Amino functionalized ionic liquid as an efficient and recyclable catalyst for knoevenagel reactions in water 显示文摘 | Cai Y Q Peng Y Q Song G H | 2006 | Catal Lett2006，109，： | 1 |
| 16 | Measurements of CH4 and N2O emissions from rice fields in Fengqiu, China显示文摘 | CAI Zu-cong XING Guang-xi SHEN G Y | 1999 | Soil Sci Plant Nutr1999，45，1： | 1 |
| 17 | Antiprotozal activities of Centipeda minima显示文摘 | Yu H W WRIGHT C W CAI Y | 1994 | Phytoherapy Research1994，8，： | 1 |
| 18 | Endothelin-1 increases expression of cyclooxygenase-2 and production of interlukin-8 in hunan pulmonary epithelial cells显示文摘 | Peng H Chen P Cai Y | 2008 | Peptides2008，29，3： | 1 |
| 19 | Methane and nitrous oxide emissions from rice paddy fields as affected by nitrogen fertilisers and water management显示文摘 | Cai Z C Xing G X Yan X Y | 1997 | Plant Soil1997，196，： | 1 |
| 20 | Tomato leaf curl Guangxi virus is a distinct begomovirus species显示文摘 | Xu Y P Cai X Z Zhou X P | 2007 | European Journal of Plant Pathology2007，118，3： | 1 |
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