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| 1 | A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol显示文摘BACKGROUND: Laparoscopic pancreaticoduodenectomy(LPD)is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes,in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy(OPD).METHODS: Between November 2005 and April 2009, 12LPDs(9 ampullary and 3 distal common bile duct tumors)were performed. A cohort of 12 OPDs were matched for age,gender, body mass index(BMI) and American Society of Anesthesiologists(ASA) score and tumor site.RESULTS: Mean tumor size LPD vs OPD(19.8 vs 19.2 mm,P=0.870). R0 resection was achieved in 9 LPD vs 8 OPD(P=1.000). The mean number of metastatic lymph nodes and total number resected for LPD vs OPD were 1.1 vs 2.1(P=0.140)and 20.7 vs 18.5(P=0.534) respectively. Clavien complications grade I/II(5 vs 8), III/IV(2 vs 6) and pancreatic leak(2 vs 1)were statistically not significant(LPD vs OPD). The mean high dependency unit(HDU) stay was longer in OPD(3.7 vs 1.4 days,P<0.001). There were 2 recurrences each in LPD and OPD(logrank,P=0.983). Overall mortality for LPD vs OPD was 3 vs 6(log-rank, P=0.283) and recurrence-related mortality was 2 vs 1.There was one death within 30 days in the OPD group secondary to severe sepsis and none in the LPD group.CONCLUSIONS: Compared to open procedure, LPD achieved a similar rate of R0 resection, lymph node harvest and longterm recurrence for tumors less than 2 cm. Though technically challenging, LPD is safe and does not compromise oncological outcome. | Abdul R Hakeem Caroline S Verbeke Alison Cairns Amer Aldouri Andrew M Smith Krishna V Menon | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 24 |
| 2 | Metabolic and Phenotypic Responses of Greenhouse-Grown Maize Hybrids to Experimentally Controlled Drought Stress显示文摘到象干旱一样的不能生活的压力的改编是农业上的重要获得相关庄稼相似玉米。在在干旱是一个很主导的应力因素的气候的地区种的庄稼的提高的干旱公差的开发因此在植物繁殖起一个必要作用。以前的研究证明玉米收益潜力和提高的压力忍耐是联系特点。在这研究,我们为他们在一个温室实验处理干旱应力的能力分析了六个不同玉米混血儿。我们能从从不同机关与新陈代谢的数据在浇得好的条件下面并且在水限制下面测量的 morphophysiological 参数联合数据。这些不同机关拥有了不同代谢物作文,与显示最可观的 metabolome 变化追随者水缺乏的叶片。虽然我们能在干旱应力下面在代谢物层次显示出一般增加,包括在 TCA 周期的氨基酸,糖,糖白酒,和中介变化,这些变化不在以前基于领域试用数据被指定了为干旱容忍或易受影响的玉米混血儿之间是微分的。这里描述的数据与相当不同的生长源于一个温室实验的事实调节与相比这个领域里的可以解释忍耐为什么组织的天赋不能在这研究被证实。然而,我们能加亮象其层次某些生理的特点地相关很好的代谢物一样显示了保存回答到干旱的几代谢物。 | Sandra Witt Luis Galicia Jan Lisec Jill Cairns Axel Tiessen Jose Luis Araus Natalia Palacios-Rojas Alisdair R. Fernie | 2012 | Molecular Plant2012，5，2： | 12 |
| 3 | The adult human testis transcriptional cell atlas显示文摘Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and differentiation,alongside complex germ cell-niche interactions,to ensure long-term fertility and faithful genome propagation. Here,we performed single-cell RNA sequencing of -6500 testicular cells from young adults. We found five niche/somatic cell types (Leydig,myoid,Sertoli,endothelial,macrophage),and observed germline-niche interactions and key human-mouse differences. Spermatogenesis,including meiosis,was reconstructed computationally,revealing sequential coding,non-coding,and repeat-element transcriptional signatures. Interestingly,we identified five discrete transcriptional/developmental spermatogonial states,including a novel early SSC state,termed State 0. Epigenetic features and nascent transcription analyses suggested developmental plasticity within spermatogonial States. To understand the or丨gin of State 0,we profiled testicular cells from infants,and identified distinct similarities between adult State 0 and infant SSCs. Overall,our datasets describe key transcriptional and epigenetic signatures of the normal adult human testis,and provide new insights into germ cell developmental transitions and plasticity. | Jingtao Guo Edward J. Grow Hana Mlcochova Geoffrey J. Maher Cecilia Lindskog Xichen Nie Yixuan Guo Yodai Takei Jina Yun Long Cai Robin Kim Douglas T. Carrell Anne Goriely James M. Hotaling Bradley R. Cairns | 2018 | Cell Research2018，28，12： | 12 |
| 4 | Pathology grading of colon cancer surgical resection and its association with survival: a retrospective observational study显示文摘 | Nicholas P West Eva JA Morris Olorunda Rotimi Alison Cairns Paul J Finan Philip Quirke | 2008 | Lancet Oncology2008，，9： | 4 |
| 5 | Competition and regulation in the taxi industry显示文摘 | Robert D. Cairns Catherine Liston-Heyes | 1996 | Journal of Public Economics1996，，1： | 2 |
| 6 | HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption显示文摘 | Ioanna Papandreou Rob A. Cairns Lucrezia Fontana Ai Lin Lim Nicholas C. Denko | 2006 | Cell Metabolism2006，，3： | 2 |
| 7 | Behaviour of Concrete beams with Exposed Reinforcement显示文摘 | Cairns J Zhao Z | 1993 | Structures and Buildings1993，99，2： | 2 |
| 8 | TIMI Risk Score for ST-Elevation Myocardial Infarction: A Convenient, Bedside, Clinical Score for Risk Assessment at Presentation: An Intravenous nPA for Treatment of Infarcting Myocardium Early II Trial Substudy显示文摘 | David A. Morrow Elliott M. Antman Andrew Charlesworth Richard Cairns Sabina A. Murphy James A. de Lemos Robert P. Giugliano Carolyn H. McCabe Eugene Braunwald | 2000 | Circulation: Journal of the American Heart Association2000，，17： | 2 |
| 9 | Macroinvertebrate assemblages of surface mine wetlands of Southwest Virginia,USA显示文摘MacroinvertebrateassemblagesofsurfaceminewetlandsofSouthwestVirginia,USA￥DavidH.Jones;RobertB.Atkinson;JohnCairns,Jr.(Departm... | David H.Jones Robert B. Atkinson John Cairns,Jr.(Department of Biology,Virginia Polytechnic Institute and State University, Blacksburg,Virginia 24061 USA) | 1996 | Journal of Environmental Sciences1996，8，1： | 2 |
| 10 | Pricing death: Frameworks for the valuation and securitization of mortality risk 显示文摘 | Cairns A J G Blake D Dowd K | 2006 | ASTIN Bulletin2006，36，1： | 1 |
| 11 | Rude unhinging of the machinery of life: metabolic approaches to hemorrhagic shock显示文摘 | Cairns CB | 2001 | Curr Opin Crit Care2001，7，6： | 1 |
| 12 | Improving costing methods in multicentre economic evaluation: the use of multiple imputation for unit costs 显示文摘 | Grieve R Cairns J Thompson S G Thompson | 2010 | Health Economics2010，19，8： | 1 |
| 13 | The origin of mutants显示文摘 | Cairns J Overbaugh J Meller S | 1988 | Nature1988，335，6186： | 1 |
| 14 | Flat and depressed colonic neoplasms:a prospective study of 1000 colonoscopies in the UK显示文摘 | Rembacken B J Fujii T Cairns A | 2000 | Lancet2000，355，9211： | 1 |
| 15 | Electrochemical behavior of LiMn2O4 and LiCoO2 thin film produced with pulsed laser deposition显示文摘 | Striebel K A Deng C Z Cairns E J | 1996 | J Electrochem Soc1996，143，6： | 1 |
| 16 | Hair follicle dermal cells repopulate the mouse haematopoietic system显示文摘 | Lako M Armstrong L Cairns PM | 2002 | J Cell Sci2002，115，20： | 1 |
| 17 | Hair follicle derml cells repopulate the mouse haematopoietie system显示文摘 | Lako M Armstrong L Cairns P M | 2002 | J Cell Sei2002，115，20： | 1 |
| 18 | High frequency of p16 (CDKN2/MTS - 1/INK4A) inactivation in head and neck squamous cell carcinoma 显示文摘 | REED A L CALIFANO J CAIRNS P | 1996 | Cancer Res1996，56，16： | 1 |
| 19 | Usability analysis with Markov models 显示文摘 | Thimbleby Harold Cairns Paul A Jones Matt | 2001 | ACM Transactions on Computer-Human Interaction2001，8，2： | 1 |
| 20 | Multidisciplinary approach to abdominal wall reconstruction after decompressive laparotomy for abdominal compartment syndrome显示文摘 | Hultman CS Pratt B Cairns BA et al | 2005 | Ann Plast Surg2005，54，27： | 1 |
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