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| 1 | Nonalcoholic fatty liver disease: An overview of current insights in pathogenesis, diagnosis and treatment显示文摘Estimates of people suffering from overweight (one billion) and obesity (300 million) are increasing. The accumulation of triglycerides in the liver, in the absence of excess alcohol intake, has been described in the early sixties. It was not until 1980, however, that Ludwig et al named this condition nonalcoholic steatohepatitis (NASH). Subsequently, nonalcoholic fatty liver disease (NAFLD) has been used as a general name for conditions ranging from simple steatosis through steatohepatitis to end-stage liver disease (cirrhosis). Many studies have demonstrated the significant correlation with obesity and insulin resistance. Other studies have revealed a signifi- cant correlation between hepatic steatosis, cardiovascu- lar disease and increased intima-media thickness. WHO estimated that at least two million patients will develop cirrhosis due to hepatic steatosis in the years to come. Longitudinal cohort studies have demonstrated that those patients with cirrhosis have a similar risk to devel- op hepatocellular carcinoma as those with other causes of cirrhosis. Taken all together, NAFLD has become the third most important indication for liver transplantation. There- fore, training programmes in internal medicine, gastroen- terology and hepatology should stress the importance of diagnosing this entity and treat properly those at risk for developing complications of portal hypertension and con- comittant cardiovascular disease. This review will focus on the clinical characteristics, pathophysiology, imaging tech- niques and the readily available therapeutic options. | Tim CMA Schreuder Bart J Verwer Carin MJ van Nieuwkerk Chris JJ Mulder | 2008 | World Journal of Gastroenterology2008，14，16： | 35 |
| 2 | Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension显示文摘 | Carine MB Kalyani B J Alan D | 2004 | Am J Physiol Regul Integr Comp Physiol2004，287，4： | 1 |
| 3 | Physicochemical studies using amylose as an in vitro model for resistant starch显示文摘 | Carins P Sun L Morris V J Ring S G | 1995 | Journal of Cereal Science1995，21，： | 1 |
| 4 | Protecting the delivery of ecosystem services显示文摘 | Carins J | 1997 | EcosystemHealth1997，3，3： | 1 |
| 5 | A MYB Transcription Factor Regulates Very-Long-Chain Fatty Acid Biosynthesis for Activation of the Hypersensitive Cell Death Response in Arabidopsis(W)(OA)显示文摘 | Raffaele Sylvain Vailleau Fabienne Léger Amandine Joubès Jér?me Miersch Otto Huard Carine Blée Elisabeth Mongrand Sébastien Domergue Frédéric Roby Dominique | 2008 | Plant Cell2008，，3： | 1 |
| 6 | 3-Nitropropionic acid: a mitoehondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease显示文摘 | Emmanuel B Carine J Nicolas B | 2005 | J Neurochem2005，95，： | 1 |
| 7 | Identification of ground targets from sequential high-range-resolution radar signatures 显示文摘 | Liao X J Runkle P Carin L | 2002 | IEEE Transactions on Aerospace and Electronic System2002，38，4： | 1 |
| 8 | Nutritional compositions con-talning beta casomorphins显示文摘 | Carine J Minter S Peer F | 1989 | Uk-patent Application1989，，2： | 1 |
| 9 | Functions groups in the protozoa: roles in differing ecosystems显示文摘 | Pratt J R Carins J Jr | 1985 | Protozool1985，82，3： | 1 |
| 10 | Distribution of larval krill and zooplankton in association with hydrography in Marguerite Bay,Antarctic Peninsula,in Austral fall and winter 2001 described using the Video Plankton Recorder显示文摘 | Carin J A Cabell S Davis S M | 2008 | Deep-Sea ResearchⅡ2008，55，： | 1 |
| 11 | High frequency of p16 (CDKN2/MTS21/INK4A) inactivation in head and neck squamous cell carcinoma显示文摘 | Recd AL Califano J Carins P | 1996 | Cancer Res1996，56，： | 1 |
| 12 | Electromagnetic target detection in uncertain media:Time-reversal and minimum-variance algorithms显示文摘 | Liu D Krolik J Carin L | | 0，，04： | 1 |
| 13 | Distribution of larval krill and zooplankton in association with hydrography in Marguerite Bay, Antarctic Peninsula, in austral fall and winter 2001 described using the Video Plankton Recorder 显示文摘 | CARIN J A CABELL S DAVIS S M | 2008 | Deep-Sea Research II2008，，55： | 1 |
| 14 | Determination of the Major Metabolite of Phentolamine in Human Plasma and Urine by High-performance Liquid Chromatography 显示文摘 | Godbillon J Carins G | 1981 | J Chromatogr1981，222，： | 1 |
| 15 | Multilevel fast multipole algorithm for general targets on a half-space interface 显示文摘 | Liu Z J He J Q Xie Y J Sullivan A Carin L | 2002 | IEEE Trans Antennas Propagat2002，50，12： | 1 |
| 16 | Bayesian compres sive sensing 显示文摘 | J] S H XUE Y CARIN L | 2008 | IEEE Trans on Signal Process- ing2008，56，6： | 1 |
| 17 | Physicochemical studies using amylose as an in vitro model for resistant starch显示文摘 | CARINS P SUN L MORRIS V J | 1995 | Journal of Cereal Science1995，21，1： | 1 |
| 18 | Measurements of thermal gradients and their effects on segmental concrete bridge 显示文摘 | Carin L John E Cawrse J | 2002 | Journal of Bridge Engineering ASCE2002，7，3： | 1 |
| 19 | Measurements of Thermal Gradients and Their Effecls on Segmental Concrete Bridge显示文摘 | Carin L John E Cawrse J | 2002 | Journal of Bridge Engineering ASCE2002，7，3： | 1 |
| 20 | Identifability of a nonlinear delayed-differential aerospace model显示文摘 | Lilianne DV Carine J Ghislaine J B | | 0，，01： | 1 |
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