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| 1 | Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin显示文摘AIM: To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with ironrefractory or iron-dependent anaemia of previously unknown origin. METHODS: Consecutive patients with chronic irondeficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication. RESULTS: H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P < 0.0001) with an OR of 9.8 (95%CI: 3.3-29.6). In these patients, anaemia resolution occurred in the first follow-up visit at 6 mo, and no anaemia or iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo. CONCLUSION: Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients. | Helena Monzón Montserrat Forné Maria Esteve Mercé Rosinach Carme Loras Jorge C Espinós Josep M Viver Antonio Salas Fernando Fernández-Baares | 2013 | World Journal of Gastroenterology2013，19，26： | 13 |
| 2 | Radiation and concomitant chemotherapy for patients with glioblastoma multiforme显示文摘Postoperative external beam radiotherapy was considered the standard adjuvant treatment for patients with glioblastoma multiforme until the advent of using the drug temozolomide(TMZ) in addition to radiotherapy. High-dose volume should be focal, minimizing whole brain irradiation. Modern imaging, using several magnetic resonance sequences, has improved the planning target volume definition. The total dose delivered should be in the range of 60 Gy in fraction sizes of 1.8-2.0 Gy. Currently, TMZ concomitant and adjuvant to radiotherapy has become the standard of care for glioblastoma multiforme patients. Radiotherapy dose-intensification and radiosensitizer approaches have not improved the outcome. In spite of the lack of high quality evidence, stereotactic radiotherapy can be considered for a selected group of patients. For elderly patients, data suggest that the same survival benefit can be achieved with similar morbidity using a shorter course of radiotherapy(hypofractionation). Elderly patients with tumors that exhibit methylation of the O-6-methylguanine-DNA methyltransferase promoter can benefit from TMZ alone. | Salvador Villà Carme Balaà Sílvia Comas | 2014 | Chinese Journal of Cancer2014，33，1： | 6 |
| 3 | Endosonography-guided drainage of pancreatic fluid collections with a novel lumen-apposing stent显示文摘 | Joan B. Gornals Carlos la Serna-Higuera Andrés Sánchez-Yague Carme Loras Andrés M. Sánchez-Cantos Manolo Pérez-Miranda | 2013 | Surgical Endoscopy2013，，4： | 4 |
| 4 | BCL-XL regulates TNF-α-mediated cell death independently of NF-κB, FLIP and IAPs显示文摘 | Raffaella Gozzelino Carme Sole Nuria Llecha Miguel F Segura Rana S Moubarak Victoria Iglesias-Guimarais M Jose Perez-Garcia Stephanie Reix Jisheng Zhang Nahuai Badiola Daniel Sanchis Jose Rodriguez-Alvarez Ramon Trullas Victor J Yuste Joan X Comella | 2008 | Cell Research2008，18，10： | 4 |
| 5 | rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study显示文摘AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of bleeding.CONCLUSION Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. | Henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 6 | A possible involve-ment of gibberellic acid in celery resistance to patho-gens during storage显示文摘 | Afek U Aharoni N Carmeli S | 1994 | Acta Hortieuturae1994，38，1： | 1 |
| 7 | Effects of antibiotcs nosoeomial epidemiology of vaneomyein-resistant enterococci显示文摘 | Harbarth S Cosgrove S Carmeli Y | 2002 | Antimierob Agents Chemother2002，46，6： | 1 |
| 8 | Sipholenol and sipholenone, two new triterpenes from the marine sponge Siphonochalina sipkonella (levi) 显示文摘 | SHMUELI U CARMELY S GROWEISS A | 1981 | Tetrahedron Letters1981，22，7： | 1 |
| 9 | Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate 显示文摘 | CARM ICHAEL S J BEAL J DAY R O | 2002 | J Rheumatol2002，29，10： | 1 |
| 10 | Uracil moiety is required for toxicity of the cyanobacterialhepatotoxincylindrospermopsin显示文摘 | Banker R Carmeli S Werman M | 2001 | Journal of Toxicology and Environmental Health Part A2001，，62： | 1 |
| 11 | Antibiotic prophylaxis and the risk of Clostridium difficile-associated diarrhoea显示文摘 | Harbarth S Samore MH Carmeli Y | 2001 | J Hosp Infect2001，48，2： | 1 |
| 12 | High intensity ex- ercise increases expression of matrix metalloproteinases in fast skeletal muscle fibres显示文摘 | CARMELI E MOAS M LENNON S | 2005 | Exp Physiol2005，90，4： | 1 |
| 13 | Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgicalsite infection显示文摘 | Engemann J J Carmeli Y Cosgrove S E | 2003 | Clin Infect Dis2003，36，5： | 1 |
| 14 | High level of an- timicrobial co-resistance among extended-spectrum β- lacta- mase-producing Enterobaeteriaceae 显示文摘 | Schwaber MJ Navon-Venezia S Carmeli Y | 2005 | Antimicrob Agents Chem other2005，49，5： | 1 |
| 15 | Sulfamethoxazole abatement by photo-Fenton toxicity, inhibition and biodegradability assessment of intermediates显示文摘 | OSCAR G CARME S SANTIAGO E | 2007 | Journal of Hazardous Materials2007，146，3： | 1 |
| 16 | Increasing Celery Resistance to Pathogens during Storage and Reducing High-risk Psoralen Concentration by treatment with GA3 显示文摘 | Afek U Aharoni N Carmeli S | 1995 | JAMER Soe HORT Sci1995，120，4： | 1 |
| 17 | High level of an- timicrobial co resistance among extended-spectrum t?-lacta- mase producing Enterobacteriaceae 显示文摘 | Schwaber MJ Navon-Venezia S Carmeli Y | 2005 | Antimicrob Agents Chemother2005，49，5： | 1 |
| 18 | High tigecycline resistence in muhidrug-resistant acinetobacter baumannii显示文摘 | Navon-Venezia S Leavitt A Carmeli Y | 2007 | J Antimicrob Chemother2007，59，4： | 1 |
| 19 | Biofilm formation and susceptibility to gentamicin and colistin of extremely drug-resist- ant KPC-producing Klebsiella pneumoniae 显示文摘 | Naparstek L Carmeli Y Navon-Venezia S | 2014 | J Antimicrob Che- mother2014，69，4： | 1 |
| 20 | Effects of a treadmill walking program on muscle strength and balance in elderly people with Down syndrome显示文摘 | Carmeli E Kessel S | 2002 | J Gerontol A Biol Sic Meb Sci2002，57，2： | 1 |
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