|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated.RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and hemorrhoid classification) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in4/251 and 14/133 patients with baseline thrombosis in the rSK and hydrocortisone acetate groups, respectively(P < 0.001). There were no adverse events attributable to the experimental treatment.CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García Juan E Domínguez-Suárez Pedro A López-Saura 无 | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 2 | Pancreaticβ-cell dysfunction in type 2 diabetes:Implications of inflammation and oxidative stress显示文摘Insulin resistance and pancreaticβ-cell dysfunction are major pathological mechanisms implicated in the development and progression of type 2 diabetes(T2D).Beyond the detrimental effects of insulin resistance,inflammation and oxidative stress have emerged as critical features of T2D that defineβ-cell dysfunction.Predominant markers of inflammation such as C-reactive protein,tumor necrosis factor alpha,and interleukin-1βare consistently associated withβ-cell failure in preclinical models and in people with T2D.Similarly,important markers of oxidative stress,such as increased reactive oxygen species and depleted intracellular antioxidants,are consistent with pancreaticβ-cell damage in conditions of T2D.Such effects illustrate a pathological relationship between an abnormal inflammatory response and generation of oxidative stress during the progression of T2D.The current review explores preclinical and clinical research on the pathological implications of inflammation and oxidative stress during the development ofβ-cell dysfunction in T2D.Moreover,important molecular mechanisms and relevant biomarkers involved in this process are discussed to divulge a pathological link between inflammation and oxidative stress duringβ-cell failure in T2D.Underpinning the clinical relevance of the review,a systematic analysis of evidence from randomized controlled trials is covered,on the potential therapeutic effects of some commonly used antidiabetic agents in modulating inflammatory makers to improveβ-cell function. | Phiwayinkosi V Dludla Sihle E Mabhida Khanyisani Ziqubu Bongani B Nkambule Sithandiwe E Mazibuko-Mbeje Sidney Hanser Albert Kotze Basson Carmen Pheiffer Andre Pascal Kengne | 2023 | World Journal of Diabetes2023，14，3： | 2 |
| 3 | Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study显示文摘 | Sheila A Bingham Nicholas E Day Robert Luben Pietro Ferrari Nadia Slimani Teresa Norat Fran?oise Clavel-Chapelon Emmanuelle Kesse Alexandra Nieters Heiner Boeing Anne Tj?nneland Kim Overvad Carmen Martinez Miren Dorronsoro Carlos A Gonzalez Timothy J Key | 2003 | The Lancet2003，，9368： | 1 |
| 4 | Inhibition of glioblastoma angiogenesis and invasion by combined treatments directed against vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and vascular endothelial-cadherin显示文摘 | Katrin L Marc AB Carmen E | 2005 | Clin Cancer Res2005，11，： | 1 |
| 5 | MYD88 L265P is a marker highly characteristic of, but not restricted to, Waldenstriim's macroglobulinemia显示文摘 | Jimenez C Sebastian E Del Carmen Chilion M | 2013 | Leukemia2013，，： | 1 |
| 6 | Disruption of the Arabidopsis cir- cadian clock is responsible for extensive variation in the cold-responsive tran- scriptome显示文摘 | Zuzanna B Carmen E Armin S et ai | 2008 | Plant Physiology2008，147，1： | 1 |
| 7 | Differential gene expression assessed by cDNA microarray analysis in breast cancer tissue under tamoxifen treatment显示文摘 | del Carmen Garcia Molina Wolgien M da Silva I D Villanova F E | 2005 | Eur J Gynaecol Oncol2005，26，5： | 1 |
| 8 | Influence of the acidbase properities of solid catalysts derived from hydrotalicite like compounds on the condensation of formaldehyde and acetaldehyde显示文摘 | Dumitriu E Vasile H Carmen C | 1987 | Journal of Catalysis1987，107，1： | 1 |
| 9 | Adsorption of free lead (Pb^2+ ) by pedogenic oxides, ferrihydrite and leaf compost 显示文摘 | Sebastien S Carmen E M Murray M B | 2000 | Soil Science Society of America Journal2000，64，： | 1 |
| 10 | Transcriptional repressionby UME6 involves deacetylation of lysine 5 of histone H4 byRPD3显示文摘 | Rundlett Stephen E Carmen | 1998 | Nature1998，392，6678： | 1 |
| 11 | Place attachment and place identity in natives and non-natives显示文摘 | HERNáNDEZ B CARMEN HIDALGO M SALAZAR-LAPLACE M E | 2007 | Journal of environmental psychology2007，27，4： | 1 |
| 12 | Oxygen inhibition and coating thickness effects on UV radiation curing of weather fast clear coats studied by photo-DSC显示文摘 | Carmen Silvia Bentivoglio Ruiz Luci Diva B Machado J E Volponi | 2004 | Journal of Thermal Analysis and Calorimetry2004，，75： | 1 |
| 13 | Multiprimer PCR system for differential identification of mycobacteria in Clinical samples显示文摘 | Patricia DP Carmen Thomas M Martinez E | 1966 | Clin Microbiol1966，34，2： | 1 |
| 14 | Vicitims of violence and psychiatric illness 显示文摘 | CARMEN E RIECKER P MILLS T | 1984 | Am J Psychiatry1984，141，： | 1 |
| 15 | Effect of Germinated Soy Protein on the Growth of He La Cervical Cancer Cells in Female Ethylic mice 显示文摘 | Del Carmen Robles-Ramirez M Ramon-Gallegos E Reyes-Duarte FJ et al | 2012 | Nut Cancer2012，4，8： | 1 |
| 16 | A highty sensitive Genetic protocal to detect NF,mutations显示文摘 | Carmen Valero M Martin Y Hernandez-Imaz E | 2011 | J Mol Diagn2011，13，2： | 1 |
| 17 | A Randomized Controlled Trial of Resistance Exercise Training to Improve Glycemie Control in Older Adults With Type 2 Diabetes显示文摘 | Carmen Castaneda MD PHD Jennifer E | 2002 | Diabetes Care2002，25，12： | 1 |
| 18 | Effect of preparation conditions on phase formation, densification and microstructure evolution in La-β- Al2O3/Al2O3 composites显示文摘 | Carmen B S Luis E Gary L M | 1999 | J Am Ceran Soc1999，82，5： | 1 |
| 19 | Cloning and assembly strategies in microbial genome projects显示文摘 | Lionel Frangeul Karen E Nelson Carmen Buchrieser | 1999 | Microbiology1999，145，： | 1 |
| 20 | Reversed-phase liquid chromatography on an amide stationary phase for the determination of the B group vitamins in baby foods显示文摘 | PILAR V CARMEN L E NURIA B | 2003 | J Chromatogr: A2003，1007，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员