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| 1 | N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects. | Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 2 | Experi- mental and numerical investigation of fluid flow and mixing in pachuca tanks显示文摘 | Rodriguez M E Castillejos E AH Acosta G FA | 2007 | Metallurgical and Materials Transac- tions B2007，38，4： | 1 |
| 3 | A controlled, randomized, double-blind trial to evaluate the effect of a supplement of cocoa husk that is rich in dietary fiber on colonic transit in constipated pediatric patients显示文摘 | Castillejo G Bull6 M Anguera A | 2006 | Official Journal of the American Academy of Pediatrics2006，118，3： | 1 |
| 4 | Effect of the operating conditions of air-mist nozzles on the thermal evolution of continuously cast thin slabs显示文摘 | Montes R J J Castillejos E A H Acosta G F A Herrera G MA | 2008 | Canadian Metallurgical Quarterly2008，47，： | 1 |
| 5 | QTL analysis for ascorbic acid content in strawberry fruit reveals a complex genetic architecture and association with GDP-L-galactose phosphorylase显示文摘Strawberry(Fragaria×ananassa)fruits are an excellent source of L-ascorbic acid(AsA),a powerful antioxidant for plants and humans.Identifying the genetic components underlying AsA accumulation is crucial for enhancing strawberry nutritional quality.Here,we unravel the genetic architecture of AsA accumulation using an F1 population derived from parental lines‘Candonga’and‘Senga Sengana’,adapted to distinct Southern and Northern European areas.To account for environmental effects,the F1 and parental lines were grown and phenotyped in five locations across Europe(France,Germany,Italy,Poland and Spain).Fruit AsA content displayed normal distribution typical of quantitative traits and ranged five-fold,with significant differences among genotypes and environments.AsA content in each country and the average in all of them was used in combination with 6,974 markers for quantitative trait locus(QTL)analysis.Environmentally stable QTLs for AsA content were detected in linkage group(LG)3A,LG 5A,LG 5B,LG 6B and LG 7C.Candidate genes were identified within stable QTL intervals and expression analysis in lines with contrasting AsA content suggested that GDP-L-Galactose Phosphorylase FaGGP(3A),and the chloroplast-located AsA transporter gene FaPHT4;4(7C)might be the underlying genetic factors for QTLs on LG 3A and 7C,respectively.We show that recessive alleles of FaGGP(3A)inherited from both parental lines increase fruit AsA content.Furthermore,expression of FaGGP(3A)was two-fold higher in lines with high AsA.Markers here identified represent a useful resource for efficient selection of new strawberry cultivars with increased AsA content. | Pilar Muñoz Cristina Castillejo JoséAntonio Gómez Luis Miranda Silke Lesemann Klaus Olbricht Aurélie Petit Philippe Chartier Annika Haugeneder Johanna Trinkl Luca Mazzoni Agnieszka Masny Edward Zurawicz Freya Maria Rosemarie Ziegler Björn Usadel Wilfried Schwab Béatrice Denoyes Bruno Mezzetti Sonia Osorio JoséFSánchez-Sevilla Iraida Amaya | 2023 | Horticulture Research2023，10，3： | 1 |
| 6 | Growthmodeling of Listeria monocytogenes in packaged fresh greenasparagus显示文摘 | A M Castillejo R E Barco A R M Garcia G | 2000 | Food Microbiology2000，17，4： | 1 |
| 7 | Modelling Molten Flux Layer Thickness Profiles in Compact Strip Process Moulds for Continuous Thin Slab Casting显示文摘 | Maclas A E Castillejos E A H Acosta G F A | 2002 | Ironmaking and Steelmaking2002，29，5： | 1 |
| 8 | A controlled, randomized, double-blind trial to evaluate the effect of a supplement of cocoa husk that is rich in dietary fiber on colonic transit in constipated pediatric patients 显示文摘 | Castillejo G Bullo M Anguera A | 2006 | Pediatrics2006，118，3： | 1 |
| 9 | A mathenratical model of ahnninum depth filtration with ceramic foam filters: Part Ⅱ: Application to Long-term filtration显示文摘 | ACOSTA G F A CASTILLEJOS E A H | 2000 | Metallurgical and Materials Transactions2000，，： | 1 |
| 10 | Promoter hypermethylation and global hypomethylation are independent epigenetic events in lymphoid leukemogenesis with opposing effects on clinical outcome显示文摘 | Roman-Gomez J Jimenez-Velasco A Agirre X Castillejo JA Navarro G Garate L | 2006 | Leukemia2006，20，8： | 1 |
| 11 | A controlled, ran- domized, double - blind trial to evaluate the effect of a supple- ment of cocoa husk that is rich in dietary fiber on colonic transit in constipated pediatric patients 显示文摘 | Castillejo G Bull M Anguera A | 2006 | Pediatrics2006，118，3： | 1 |
| 12 | A Thermal Study to Improve the Lifetime of Billet-type Bottom Electrodes of DC Electric Arc Furnaces:Part 1-Melting of the Metallic Charge 显示文摘 | CASTILLEJOS A H ACOTA F A CINVESTAV G | 2001 | I&SM2001，，10： | 1 |
| 13 | Promoter hypermethylation of cancerrelated genes: a strong independent prognostic factor in acute lymphoblastic leukemia 显示文摘 | RomanGomez J JimenezVelasco A Castillejo JA Agirre X Barrios M Navarro G | 2004 | Blood2004，104，8： | 1 |
| 14 | A controlled,randomized,double-blind trial to evaluate the effect of a supplement of cocoa husk that is rich in dietary fiber on colonic transit in constipated pediatric patients显示文摘 | CASTILLEJO G BULLO M ANGUERA A | 2006 | Pediatr2006，118，3： | 1 |
| 15 | CpG island methylator phenotype redefines the prognostic effect of t(12;21) in childhood acute lymphoblastic leukemia显示文摘 | Roman-Gomez J Jimenez-Velasco A Agirre X Castillejo JA Navarro G Calasanz MJ | 2006 | Clin Cancer Res2006，12，16： | 1 |
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