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| 1 | Recombinant streptokinase vs phenylephrine-based suppositories in acute hemorrhoids, randomized, controlled trial(THERESA-3)显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) and phenylephrine-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(14 sites), randomized(1:1), open, parallel groups, active controlled trial was done. After inclusion, subjects with acute symptoms of hemorrhoids, who gave their written, informed consent to participate, were centrally randomized to receive, as outpatients, rSK(200000 IU) or 0.25% phenylephrine suppositories, which had different organoleptic characteristics. Treatment was administered by the rectal route, one unit every 6 h during 48 h for rSK, and up to a maximum of 5 d(20 suppositories) for phenylephrine. Evaluations were performed at 3, 5 and 10 d postinclusion. The main end-point was the 5th-day complete clinical response(disappearance of pain and edema, and ≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were evaluated too. RESULTS: 5thday complete response rates were 83/110(75.5%) and 36/110(32.7%) with rSK and phenylephrine suppositories, respectively. This 42.7% difference(95%CI: 30.5-54.2) was highly significant(P < 0.001). The advantage was detected since the early 3rdday evaluation(37.3% vs 6.4% for the rSK and active control groups, respectively; P < 0.001) and was kept even at the late 10thday assessment(83.6% vs 58.2% for rSK and phenylephrine, respectively; P < 0.001). Time for complete response was significantly shorter(P = 0.031; log-rank test) in the rSK group(median: 4.9 d; 95%CI: 4.8-5.0) with respect to the active control(median: 9.8 d; 95%CI: 9.8-10.0). Thrombectomy was necessary in 1/59 and 8/57 patients with baseline thrombosis in the rSK and phenylephrine groups, respectively(P = 0.016). There were no adverse events attributable to the experimental treatment. CONCLUSION: rSK suppositories showed a significant advantage over a widely used over-the-counter phen-ylephrine preparation for the treatment of acute hemorrhoidal illness, with an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-lvarez Roselin Valle-Cabrera Ana Aguilera-Barreto Pedro A López-Saura | 2014 | World Journal of Gastroenterology2014，20，6： | 4 |
| 2 | Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated.RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and hemorrhoid classification) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in4/251 and 14/133 patients with baseline thrombosis in the rSK and hydrocortisone acetate groups, respectively(P < 0.001). There were no adverse events attributable to the experimental treatment.CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García Juan E Domínguez-Suárez Pedro A López-Saura 无 | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 3 | Dexmedetomidine for deep brain stimulator placement in a child with primary generalized dystonia:case report and literature review显示文摘 | Maurtua MA Cata JP Martirena M | 2009 | J Clin Anesth2009，21，3： | 1 |
| 4 | Effects of surgery,general anesthe- sia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer显示文摘 | Cata JP Bauer M Sokari T | 2013 | J C lin Anesth2013，25，4： | 1 |
| 5 | Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer显示文摘 | Cata JP Bauer M Sokari T | 2013 | J Clin Anesth2013，25，4： | 1 |
| 6 | Management of chemotherapy-induced peripheral neuropathy 显示文摘 | Stillman M Cata JP | 2006 | Curr Pain Headache Rep2006，10，4： | 1 |
| 7 | Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer 显示文摘 | Cata JP Bauer M Sokari T | 2013 | J Clin Anesth2013，25，4： | 1 |
| 8 | Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer 显示文摘 | Cata JP Bauer M Sokari T | 2013 | J Clin Anesth2013，25，25： | 1 |
| 9 | Carcinoma of the colon:long time survival ang prognosis arter surgical treatment in a series of 798 parients显示文摘 | Cata M | 1987 | world J Surg1987，206，1： | 1 |
| 10 | Modelling human development and disease in pluripotcnt stem-cell derived gastric organoids 显示文摘 | MCCRACKEN K W CATA E M CRAWFORD C M | 2014 | Nature2014，516，7531： | 1 |
| 11 | Dexamethasone treatment does not improve the outcome of women with HELLP syndrome:a double-blind,placebo-controlled,randomized clinical trial显示文摘 | Fonseca JE Méndez F Catao C | 2005 | Am J Obstet Gynecol2005，193，5： | 1 |
| 12 | Effects of surgery,gen- eral anesthesia,and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer显示文摘 | Cata JP Bauer M Sokari T et a/ | 2013 | J Clin Anesth2013，25，4： | 1 |
| 13 | The effects of thalidomide and minocycline on taxol-induced hyperalygesia in rats 显示文摘 | Cata J P Weng H R Dougherty P M | 2008 | Brain Res2008，1229，： | 1 |
| 14 | Dexmedetomidine for deep brain stimulator placement in a child with primary generalized dystonia: case report and literature review 显示文摘 | MAURTUA MA CATA JP MARTIRENA M | 2009 | J Clin Anesth2009，21，3： | 1 |
| 15 | Modelling human development and disease in plu- ripotent stem-cell-derived gastric organoids 显示文摘 | McCRACKEN K W CATAE M CRAWFORD C M | 2014 | Na- ture2014，516，： | 1 |
| 16 | A novel cold inducible gene from Arabidopsis, RCB, encodesaper oxidase that constitutes a component for stress tolerance 显示文摘 | LIORENTE F LOPEZCR M CATA R | 2002 | Plant J2002，32，： | 1 |
| 17 | A genetically humanized mouse model for hepatitis C virus infection显示文摘 | Domer M Horwitz J A Robbins J B Barry W T Feng Q Mu K Jones C T Schoggins J W Cata | | 0，，7350： | 1 |
| 18 | Effects of surgery,general anesthesia,and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer显示文摘 | Cata JP Bauer M Sokari T | 2013 | J Clin Anesth2013，25，4： | 1 |
| 19 | Effects of surgery, general anesthesia, and perioperative epidural analgesia on the im- mune function of patients with non-small cell lung cancer 显示文摘 | Cata JP Bauer M Sokari T | 2013 | Journal of Clinical Anesthesia2013，25，4： | 1 |
| 20 | Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer显示文摘 | Cata JP Bauer M Sokari T | 2013 | J Clin Anesth2013，9，5： | 1 |
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