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| 1 | Use of exclusive enteral nutrition in adults with Crohn's disease: A review显示文摘Exclusive enteral nutrition(EEN)is well-established as a first line therapy instead of corticosteroid(CS)therapy to treat active Crohn’s disease(CD)in children.It also has been shown to have benefits over and above induction of disease remission in paediatric populations.However,other than in Japanese populations,this intervention is not routinely utilised in adults.To investigate potential reasons for variation in response between adult studies of EEN and CS therapy.The Ovid database was searched over a 6-mo period.Articles directly comparing EEN and CS therapy in adults were included.Eleven articles were identified.EEN therapy remission rates varied considerably.Poor compliance with EEN therapy due to unpalatable formula was an issue in half of the studies.Remission rates of studies that only included patients with previously untreated/new CD were higher than studies including patients with both existing and new disease.There was limited evidence to determine if disease location,duration of disease or age of diagnosis affected EEN therapy outcomes.There is some evidence to support the use of EEN as a treatment option for a select group of adults,namely those motivated to adhere to an EEN regimen and possibly those newly diagnosed with CD.In addition,the use of more palatable formulas could improve treatment compliance. | Catherine L Wall Andrew S Day Richard B Gearry | 2013 | World Journal of Gastroenterology2013，19，43： | 15 |
| 2 | The dependences of osteocyte network on bone compartment, age, and disease显示文摘Osteocytes, the most abundant bone cells, form an interconnected network in the lacunar-canalicular pore system(LCS) buried within the mineralized matrix, which allows osteocytes to obtain nutrients from the blood supply, sense external mechanical signals, and communicate among themselves and with other cells on bone surfaces. In this study, we examined key features of the LCS network including the topological parameter and the detailed structure of individual connections and their variations in cortical and cancellous compartments, at different ages, and in two disease conditions with altered mechanosensing(perlecan deficiency and diabetes).LCS network showed both topological stability, in terms of conservation of connectivity among osteocyte lacunae(similar to the ‘‘nodes' ' in a computer network), and considerable variability the pericellular annular fluid gap surrounding lacunae and canaliculi(similar to the ‘‘bandwidth'' of individual links in a computer network). Age, in the range of our study(15–32 weeks), affected only the pericellular fluid annulus in cortical bone but not in cancellous bone. Diabetes impacted the spacing of the lacunae, while the perlecan deficiency had a profound influence on the pericellular fluid annulus. The LCS network features play important roles in osteocyte signaling and regulation of bone growth and adaptation. | Xiaohan Lai Christopher Price Shannon Modla William R Thompson Jeffrey Caplan Catherine B Kirn-Safran Liyun Wang | 2015 | Bone Research2015，3，2： | 6 |
| 3 | MicroRNAs and liver cancer associated with iron overload:Therapeutic targets unravelled显示文摘Primary liver cancer is a global disease that is on the increase.Hepatocellular carcinoma(HCC)accounts for most primary liver cancers and has a notably low survival rate,largely attributable to late diagnosis,resistance to treatment,tumour recurrence and metastasis.MicroRNAs(miRNAs/miRs)are regulatory RNAs that modulate protein synthesis.miRNAs are involved in several biological and pathological processes including the development and progression of HCC.Given the poor outcomes with current HCC treatments,miRNAs represent an important new target for therapeutic intervention.Several studies have demonstrated their role in HCC development and progression.While many risk factors underlie the development of HCC,one process commonly altered is iron homeostasis.Iron overload occurs in several liver diseases associated with the development of HCC including Hepatitis C infection and the importance of miRNAs in iron homeostasis and hepatic iron overload is well characterised.Aberrant miRNA expression in hepatic fibrosis and injury response have been reported,as have dysregulated miRNA expression patterns affecting cell cycle progression,evasion of apoptosis,invasion and metastasis.In2009,miR-26a delivery was shown to prevent HCC progression,highlighting its therapeutic potential.Several studies have since investigated the clinical potential of other miRNAs with one drug,Miravirsen,currently in phaseⅡclinical trials.miRNAs also have potential as biomarkers for the diagnosis of HCC and to evaluate treatment efficacy.Ongoing studies and clinical trials suggest miRNA-based treatments and diagnostic methods will have novel clinical applications for HCC in the coming years,yielding improved HCC survival rates and patient outcomes. | Catherine M Greene Robert B Varley Matthew W Lawless | 2013 | World Journal of Gastroenterology2013，19，32： | 5 |
| 4 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 5 | Biliary obstruction caused by portal cavernoma: a study of 8 cases显示文摘 | Gabriel Perlemuter Hervé Béjanin Jacques Fritsch Frédéric Prat Marianne Gaudric Stanislas Chaussade Catherine Buffet | 1996 | Journal of Hepatology1996，，1： | 2 |
| 6 | Hepatitis C and renal disease: an update 1 1 Summary of a workshop held October 21 to 22, 2002, in the Lister Hill Auditorium, The National Institutes of Health, Bethesda, MD.显示文摘 | Catherine M Meyers Leonard B Seeff Catherine O Stehman-Breen Jay H Hoofnagle | 2003 | American Journal of Kidney Diseases2003，，4： | 2 |
| 7 | Neoadjuvant Chemotherapy plus Cystectomy Compared with Cystectomy Alone for Locally Advanced Bladder Cancer显示文摘 | H BARTON GROSSMAN RONALD B NATALE CATHERINE M | 2003 | N Engl J Med2003，349，： | 1 |
| 8 | Activation of the nuclear factor κB is a key event in brain tolerance显示文摘 | Nicolas B Catherine W Michel L | 2001 | J Neurosci2001，21，13： | 1 |
| 9 | Characterization of adsorbed species on TiO2 after photocatalytic oxidation of toluene显示文摘 | Catherine M B John L F 2001 | 2001 | J Catal2001，200，1： | 1 |
| 10 | Antibiosis revisited: bacterio- cins produced by dairy starter cultures显示文摘 | Susan F B Catherine G N | 1993 | Journal of Dairy Science1993，76，8： | 1 |
| 11 | Primary Culture of Human Atrial Myocytes is Associated with the Appearance of Structural and Functional Characteristics of Immature Myocardium显示文摘 | Agnès Bénardeau Stéphane N. Hatem Catherine Rücker-Martin Sophie Tessier Sylvie Dinanian Jane-Lyse Samuel Edouard Coraboeuf Jean-Jaques Mercadier | 1997 | Journal of Molecular and Cellular Cardiology1997，，5： | 1 |
| 12 | Human Bcl-2 protects against AMPA receptor-mediated apoptosis 显示文摘 | Nam S C Philip M B Catherine J P | 2000 | Neurochem2000，74，4： | 1 |
| 13 | ^29SiMAS NMR study of dicalcium silicate:the structural influence of sulfate and alumina stabilizers显示文摘 | LAURENTB CATHERINE B DOMINIQUE M | 1995 | J Am Ceram Soc1995，78，10： | 1 |
| 14 | Life cycle assessment of mine tailings management in Canada显示文摘 | Catherine Reid Valérie Bécaert Michel Aubertin Ralph K. Rosenbaum Louise Deschênes | 2008 | Journal of Cleaner Production2008，，4： | 1 |
| 15 | Epicatechin potentiation of glucose-stimulated insulin secretion in INS-1 cells is not dependent on its antioxidant activity显示文摘Epicatechin (EC ) 是 monomeric flavan-3-ol。我们以前证明了葡萄糖偏狭的老鼠喂了 flavan-3-ols 展览随传播导出 EC 的代谢物的增加相应的改进胰腺的小岛功能。因此,我们推测那 EC 可以在 vivo 充当一个细胞的发信号分子调制胰岛素分泌物。在这研究,我们进一步在 H2O2 或导致多糖症的 ROS 生产上检验了 EC 的不同集中的效果,以及在 vitro 在 INS-1 房间线在浸透的丰满的酸(SFA ) 上损害了刺激葡萄糖的胰岛素分泌物(GSIS ) 。我们在高度显示出那 EC 在 INS-1 房间的集中(30 mol/L ) ,然而并非低集中(0.3 mol/L ) ,显著地减少的 H2O2 或导致多糖症的 ROS 生产。然而, EC (0.3 mol/L ) 显著地在 INS-1 房间提高了损害 SFA 的 GSIS。KN-93 的增加,一个 CaMKII 禁止者,在胰岛素分泌物上堵住了 EC 的效果并且减少 CaMKII phosphorylation。GW1100,一个 GPR40 对手,显著地稀释的提高 EC 的 GSIS,而是仅仅在边际地影响的 CaMKII phosphorylation 的增加。这些结果证明在生理的集中的 EC 经由 CaMKII 小径的激活在损害 SFA 的房间支持 GSIS 并且作为 GPR40 ligand 与它的功能一致。调查结果在 vivo 作为一个细胞的发信号分子为 EC 支持一个角色并且进一步描出在房间的 EC 的发信号的小径。 | Kaiyuan YANG Catherine B CHAN | 2018 | Acta Pharmacologica Sinica2018，39，5： | 1 |
| 16 | A comparative study of numerical schemes and modeling显示文摘 | Catherine A B Nicolas S V | 2004 | Wind Engineering2004，28，3： | 1 |
| 17 | 18F-FDG PET imaging of rheumatoid knee synovitis correlates with dynamic magnetic resonance and sonographic assessments as well as with the serum level of metalloproteinase-3显示文摘 | Catherine Beckers Xavier Jeukens Clio Ribbens Béatrice André Stefaan Marcelis Philippe Leclercq Marie-Jo?lle Kaiser Jacqueline Foidart Roland Hustinx Michel G. Malaise | 2006 | European Journal of Nuclear Medicine and Molecular Imaging2006，，3： | 1 |
| 18 | Molting cycle-dependent expression of CYP4C15, a cytochrome P450 enzyme putatively involved in ecdysteroidogenesis in the crayfish, Orconectes limosus显示文摘 | Santiago Aragon Stéphanie Claudinot Catherine Blais Martine Ma??bèche Chantal Dauphin-Villemant | 2002 | Insect Biochemistry and Molecular Biology2002，，2： | 1 |
| 19 | Cachexia and asthenia in cancer patients 显示文摘 | Eduardo B Catherine S | 2000 | The Lancet Oncology2000，1，1： | 1 |
| 20 | Expression of laccase IIIb from the white-rot fungus Trametes versicolor in the yeast Yarrowia lipolytica for environmental applications显示文摘 | Claude J Catherine M Agathe B | 2005 | Applied Microbiology and Bioteehnology2005，66，： | 1 |
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