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| 1 | Animal models for the study of hepatitis C virus infection and replication显示文摘Hepatitis C virus (HCV) hepatitis, initially termed non-A, non-B hepatitis, has become one of the leading causes of cirrhosis and hepatocellular carcinoma worldwide. With the help of animal models, our understanding of the virus has grown substantially from the time of initial discovery. There is a paucity of available animal models for the study of HCV, mainly because of the selective susceptibility limited to humans and primates. Recent work has focused modification of animals to permit HCV entry, replication and transmission. In this review, we highlight the currently available models for the study of HCV including chimpanzees, tupaia, mouse and rat models. Discussion will include methods of model design as well as the advantages and disadvantages of each model. Particular focus is dedicated to knowledge of pathophysiologic mechanisms of HCV infection that have been elucidated through animal studies. Research within animal models is critically important to establish a complete understanding of HCV infection, which will ultimately form the basis for future treatments and prevention of disease. | Kristin L MacArthur Catherine H Wu George Y Wu | 2012 | World Journal of Gastroenterology2012，18，23： | 6 |
| 2 | Inhibition of hepatitis C virus replication by single-stranded RNA structural mimics显示文摘AIM: To examine the effect of hepatitis C virus (HCV) structural mimics of regulatory regions of the genome on HCV replication.METHODS: HCV RNA structural mimics were constructed and tested in a HCV genotype 1b aBB7 replicon,and a Japanese fulminant hepatitis-1 (JFH-1) HCV genotype 2a infection model.All sequences were computer-predicted to adopt stem-loop structures identical to the corresponding elements in full-length viral RNA.Huh7.5 cells bearing the BB7 replicon or infected with JFH-1 virus were transfected with expression vectors generating HCV mimics and controls.Cellular HCV RNA and protein levels were quantified by real-time polymerase chain reaction and Western blotting,respectively.To evaluate possible antisense effects,complementary RNAs spanning a mimic were prepared.RESULTS: In the BB7 genotype 1b replicon system,mimics of the polymerase (NS-5B),X and BA regions inhibited replication by more than 90%,50%,and 60%,respectively.In the JFH-1 genotype 2 infection system,mimics that were only 74% and 46% identical in sequence relative to the corresponding region in JFH-1 inhibited HCV replication by 91.5% and 91.2%,respectively,as effectively as a mimic with complete identity to HCV genotype 2a.The inhibitory effects were confirmed by NS3 protein levels.Antisense RNA molecules spanning the 74% identical mimic had no significant effects.CONCLUSION: HCV RNA structural mimics can inhibit HCV RNA replication in replicon and infectious HCV systems and do so independent of close sequence identity with the target. | Robert Smolic Martina Smolic John H Andorfer Catherine H Wu Robert M Smith George Y Wu | 2010 | World Journal of Gastroenterology2010，16，17： | 2 |
| 3 | 肝纤维化显示文摘 | 陆伦根 Catherine H Wu George Y Wu | 2000 | 胃肠病学2000，5，2： | 2 |
| 4 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Christopher J L Murray Theo Vos Rafael Lozano Mohsen Naghavi Abraham D Flaxman Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A | 2012 | The Lancet . 2012 (9859)2012，，9859： | 2 |
| 5 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Theo Vos Abraham D Flaxman Mohsen Naghavi Rafael Lozano Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A AlMazroa Miriam Alvara | 2012 | The Lancet . 2012 (9859)2012，，9859： | 2 |
| 6 | Effectiveness of the ureaseinhibitor NBPT for improving the efficiency of urea for ryegrass production 显示文摘 | Catherine L Y J Watson and Laughin J | 1990 | Fertilizer Research1990，24，： | 2 |
| 7 | Vaginal birth after cesarean:new insights manuscripts from an NIH consensus development conference,march 8-10,2010显示文摘 | Caroline S Catherine Y Spong CY | | 0，，05： | 1 |
| 8 | A Controlled Trial of a Critical Pathway for Treatment of Community-Acquired Pneumonia 显示文摘 | Thomas T Manle MD Catherine Y Lau | 2000 | The Journal of the American Medical Association2000，283，20： | 1 |
| 9 | Electrical Characteristics and Growth Kinetics in Discharges Used for Plasma Deposition of Amorphous Carbon显示文摘 | Catherine Y Couderc P | 1986 | Thin Solid Films1986，144，2： | 1 |
| 10 | Reconceptualizing Team Identification: New Dimensions and Their Relationship to Inter- group Bias显示文摘 | Amiot Catherine E Bourlfis Richard Y | 2005 | Group Dynamics: Theory Research & Practice2005，9，2： | 1 |
| 11 | Demand-driven acquisition at HKUST library: the new normal显示文摘 | Catherine S Y Kwok Diana L H Chan Ada S M Cheung | 2014 | Interlending & DocumentSupply2014，42，4： | 1 |
| 12 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Theo Vos Abraham D Flaxman Mohsen Naghavi Rafael Lozano Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A AlMazroa Miriam Alvara | 2012 | The Lancet2012，，9859： | 1 |
| 13 | Determinants of long - term intraocular pressure after phacoemulsification in primary angle - clo- sure glaucoma 显示文摘 | Catherine J L Cheng C Y Ko Y C | 2011 | J Glancoma2011，20，9： | 1 |
| 14 | Inhibition of HBV replication by siRNA in a stable HBV - producing cell line 显示文摘 | Masayoshi K Catherine H George Y | 2003 | Hepatology2003，38，4： | 1 |
| 15 | Reconceptualizing team identification : new dimensions and their relationship to intergroup bias 显示文摘 | Amiot Catherine E Bourhis Richard Y | 2005 | Group Dynamics: Theory Research & Practice2005，9，2： | 1 |
| 16 | Computer simulation of a carbon-deposition plasma in CH4 显示文摘 | Rhallabi A Catherine Y | 1991 | IEEE Transactions on Plasma Science1991，19，2： | 1 |
| 17 | The effects of environmental regulations on foreign direct investment显示文摘 | JOHN A LIST CATHERINE Y CO | 2000 | Journal of Environmental Economics and Management2000，40，： | 1 |
| 18 | Vitamins C and E to prevent complications of pregnancy-associated hyperten- sion 显示文摘 | James M R Leslie M Catherine Y S | 2010 | The Engl J ned2010，362，4： | 1 |
| 19 | DUROS technology delivers peptides and proteins at consistent rate continuously for 3 to 12 months 显示文摘 | Catherine M R Thomas R A Bing Y Janice D John P C Scott D L | 2008 | Journal of Diabetes Science and Technology2008，2，3： | 1 |
| 20 | Diagnosing cellular defects in an unexplained case of total fertilization failure显示文摘 | Catherine CMH Kazuto M Ryuzo Y | 2010 | Hum Reprod2010，25，： | 1 |
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