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| 1 | Management of hilar cholangiocarcinoma in the North of England: Pathology, treatment, and outcome显示文摘AIM: To assess the management and outcome of hilar cholangiocarcinoma (Klatskin tumor) in a single tertiary referral center.METHODS: The notes of all patients with a diagnosis of hilar cholangiocarcinoma referred to our unit for over an 8-year period were identified and retrospectively reviewed. Presentation, management and outcome were assessed.RESULTS: Seventy-five patients were identified. The median age was 64 years (range 34-84 years). Male to female ratio was 1:1. Eighty-nine percent of patients presented with jaundice. Most patients referred were under Bismuth classification 3a, 3b or 4. Seventy patients required biliary drainage, 65 patients required 152percutaneous drainage procedures, and 25 had other complications. Forty-one patients had 51 endoscopic drainage procedures performed (15 failed). Of these,36 subsequently required percutaneous drainage. The median number of drainage procedures for all patients was three, 18 patients underwent resection (24%), nine had major complications and three died post-operatively.The 5-year survival rate was 4.2% for all patients, 21%for resected patients and 0% for those who did not undergo resection (P = 0.0021). The median number of admissions after diagnosis in resected patients was two and three in non-resected patients (P<0.05).Twelve patients had external-beam radiotherapy, seven brachytherapy, and eight chemotherapy. There was no significant benefit in terms of survival (P = 0.46) or hospital admissions.CONCLUSION: Resection increases survival but carries the risk of significant morbidity and mortality.Percutaneous biliary drainage is almost always necessary and endoscopic drainage should be avoided if possible. | SD Mansfield O Barakat RM Charnley BC Jaques CB O'Suilleabhain PJ Atherton D Manas | 2005 | World Journal of Gastroenterology2005，11，48： | 37 |
| 2 | Volume-activated chloride currents contribute to the resting conductance and invasive migration of human glioma cells 显示文摘 | Ransom CB O'Neal JT Sontheimer H | 2001 | J Neurosci2001，21，19： | 1 |
| 3 | A global perspective on hantavirus ecology,epidemiology and disease显示文摘 | Jonsson CB Figueiredo LT Vapalahti O | 2010 | Clin Microbiol Rev2010，23，2： | 1 |
| 4 | Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2 显示文摘 | Kouzaki H O'Grady SM Lawrence CB | 2009 | J Immunol2009，183，2： | 1 |
| 5 | Programming if gene expression by polycomb group proteins显示文摘 | K(o)hler C Villar CB | | 0，，05： | 1 |
| 6 | Transloeated EspF protein from enteropathogenic Eseheriehia coli disrupts host intestinal barrier function 显示文摘 | McNamara BP Koutsouris A O 'Connell CB | 2001 | Clin Invest2001，107，5： | 1 |
| 7 | Predictors of hospital mortality in the global registry of acute coronary events显示文摘 | Granger CB Goldberg RJ Dabbous O | 2003 | Arch Intern Med2003，163，19： | 1 |
| 8 | A global perspective on hantavirus ecology,epidemiology and disease显示文摘 | Jonsson CB Figueiredo LT Vapalahti O | 2010 | Clin Microbioi Rev2010，25，2： | 1 |
| 9 | Sleep and neurobehavioral characteristics of 5-to 7-year-old with parentally reported symptoms of attention-deficit/hyperactivity disorder显示文摘 | O'Brien LM Holbrook CR Mervis CB | 2003 | Pediatrics2003，111，3： | 1 |
| 10 | Ecological footprint analysis as a tool to assess tourism sustainability 显示文摘 | Gossling S Hansson CB Horstmeier O | 2002 | Ecological Economics2002，43，23： | 1 |
| 11 | A global perspective on hantavirus ecology, epidemiology, and disease显示文摘 | Jonsson CB Figueiredo LT Vapalahti O | 2010 | Clin Microbiol Rev2010，23，2： | 1 |
| 12 | Preliminary ob- servation with dronabinol in patients with intractable pruritus secondary to cholestatic liver disease 显示文摘 | NEFFGW O'BRIEN CB REDDYKR etal | 2002 | Am J Gastroen- terol2002，97，8： | 1 |
| 13 | A global perspectiveon hantavirus ecology, epidemiology, and disease显示文摘 | Jonsson CB Figueiredo LT Vapalahti O | 2010 | Clin Micro-biol Rev2010，23，： | 1 |
| 14 | Thyroid hormone activates fibroblast growth factor receptor-1 in bone显示文摘 | Stevens DA Harvey CB Scott AJ O'Shea PJ Barnard JC Williams AJ Brady G Samarut J Chassande O Williams GR | | 0，，： | 1 |
| 15 | Clinical outcomes in patients with Chiari Ⅰ malformation: a review of 27 cases显示文摘 | Dones J De Jesus O Colen CB | 2003 | Urg Neurol2003，60，2： | 1 |
| 16 | Sleep and neurobehavioral characteristics of 5- to 7-year-old children with parentally reported symptoms of attention-deficit/hyperactivity disorder显示文摘 | O' Brien LM Holbrook CR Mervis CB | 2003 | Pediatrics2003，111，3： | 1 |
| 17 | Neurobehavioral implications of habitual snoring in children显示文摘 | O' Brien LM Mervis CB Holbrook CR | 2004 | Pediatrics2004，114，： | 1 |
| 18 | Outcomes in liver transplant recipients with hepatitis B vires: resistance and recurrence patterns from a large transplant center over the last decade显示文摘 | Neff G W O' Brien CB Nery J | 2004 | Liver Transpl2004，10，11： | 1 |
| 19 | Giant cell tumor of tendon sheath is a polyclonal cellular proliferation显示文摘 | Vogrincic GS O'connel JX Gilks CB | 1997 | Ham Pathol1997，28，： | 1 |
| 20 | Ecological footprint analysis as a tool to assess tourism sustainability 显示文摘 | Gassling S Hansson CB Horstmeier O | 2002 | Ecological Economics2002，43，23： | 1 |
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