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| 1 | Machine learning helps improve diagnostic ability of subclinical keratoconus using Scheimpflug and OCT imaging modalities显示文摘Purpose:To develop an automated classification system using a machine learning classifier to distinguish clinically unaffected eyes in patients with keratoconus from a normal control population based on a combination of Scheimpflug camera images and ultra-high-resolution optical coherence tomography(UHR-OCT)imaging data.Methods:A total of 121 eyes from 121 participants were classified by 2 cornea experts into 3 groups:normal(50 eyes),with keratoconus(38 eyes)or with subclinical keratoconus(33 eyes).All eyes were imaged with a Scheimpflug camera and UHR-OCT.Corneal morphological features were extracted from the imaging data.A neural network was used to train a model based on these features to distinguish the eyes with subclinical keratoconus from normal eyes.Fisher’s score was used to rank the differentiable power of each feature.The receiver operating characteristic(ROC)curves were calculated to obtain the area under the ROC curves(AUCs).Results:The developed classification model used to combine all features from the Scheimpflug camera and UHR-OCT dramatically improved the differentiable power to discriminate between normal eyes and eyes with subclinical keratoconus(AUC=0.93).The variation in the thickness profile within each individual in the corneal epithelium extracted from UHR-OCT imaging ranked the highest in differentiating eyes with subclinical keratoconus from normal eyes.Conclusion:The automated classification system using machine learning based on the combination of Scheimpflug camera data and UHR-OCT imaging data showed excellent performance in discriminating eyes with subclinical keratoconus from normal eyes.The epithelial features extracted from the OCT images were the most valuable in the discrimination process.This classification system has the potential to improve the differentiable power of subclinical keratoconus and the efficiency of keratoconus screening. | Ce Shi Mengyi Wang Tiantian Zhu Ying Zhang Yufeng Ye Jun Jiang Sisi Chen Fan Lu Meixiao Shen | 2020 | Eye and Vision2020，7，1： | 3 |
| 2 | Effect of Different Thawing Methods and Multiple Freeze-Thaw Cycles on the Quality of Common Carp (Cyprinus carpio)显示文摘 | Hang Wang Yongkang Luo Ce Shi Huixing Shen | 2015 | Journal of Aquatic Food Product Technology2015，，2： | 2 |
| 3 | Regulatory T cells inhibit stable contacts between CD4^+ T cells and dendritic cells in vivo 显示文摘 | Tadokoro CE Shakhar G Shen S | 2006 | J Exp Med2006，203，3： | 1 |
| 4 | Evidence for evolutionary conservation of sex-determining genes 显示文摘 | Raymond CS Shamu CE Shen MM | 1998 | Nature1998，91，6668： | 1 |
| 5 | Clinical study on mannan with TP regimen in treating patients I lung cancer显示文摘 | Yan HA Shen K peptide combined with non-small ce Prev 2013 14(8) Huang XE | 2013 | Asian Pac J Cancer2013，，： | 1 |
| 6 | Regulatory T cells inhibit stable contacts between CD4 + T cells and dendritic cells in vivo显示文摘 | Tadokoro CE Shakhar G Shen S | 2006 | J Exp Med2006，203，3： | 1 |
| 7 | Long-term global retinal microvascular changes in a transgenic vascular endothelial growth factor mouse model显示文摘 | Shen WY Lai CM Graham CE | 2006 | Diabetologia2006，49，7： | 1 |
| 8 | Maximum likelihood estimation of receiver operating characteristic (ROC) curves from continuously-distributed data显示文摘 | Metz CE Herman BA Shen JH | 1998 | Stat Med1998，17，9： | 1 |
| 9 | Williamson,China's New Rural Pension Scheme:Can It Be Improved?显示文摘 | CE Shen JOHN B | 2013 | International Journal of Sociology and Social Policy2013，30，56： | 1 |
| 10 | Maximum-likelihood estimation of receiver operating characteristic(ROC) curves from continuously-distributed data显示文摘 | Herman BA Shen JH | 1998 | Statistics in Medicine1998，17，9： | 1 |
| 11 | Williamson,China's New Rural Pen-sion Scheme:Can It Be Improved?显示文摘 | CE Shen JOHN B | 2010 | InternationalJournal of Sociology and Social Policy2010，30，56： | 1 |
| 12 | Evidence for evolutionary conservation of sex-determining genes显示文摘 | Raymond CS Shamu CE Shen MM | 1998 | Nature1998，391，6668： | 1 |
| 13 | Maximum-likelihood estimation of receiver operating characteristic(ROC) curves from continously-distributed data显示文摘 | Metz CE Herman BA Shen JH | | 0，，： | 1 |
| 14 | Self-assembly and pH-Responsive Properties of Poly(L-glutamic acid-r-Lleucine) and Poly(L-glutamic acid-r-L-leucine)-b-Polysarcosine显示文摘Polypeptides and polypeptoids were widely used as biomedical materials because of their good biocompatibility.In this work we reported a series of p H-responsive copolypeptides and polypeptide-polypeptoid block copolymers,i.e.random copolymers of L-glutamic acid(Glu) with L-leucine(Leu) [poly(Glu-r-Leu)s],as well as their block copolymers with polysarcosine(poly Sar).Well-defined poly(Glu-r-Leu)s with predictable compositions and molecular weights were synthesized by ring opening polymerization of corresponding N-carboxyanhydride monomers.We investigated the relationship between hydrophilicity-hydrophobicity transition and copolymer composition.With increasing Leu fraction,both the p H value of cloud point and the micellar size increased.Poly(Glu-r-Leu) with 60% Leu exhibited a cloud point at the p H of 5.0 to 6.0 the same as that in endosome and lysosome.Poly(Glu-r-Leu)-b-poly Sars assembled in phosphate buffer and performed p H-responsive morphology change from orbicular micelles at high p H to worm-like micelles at low p H.They were potential p H-responsive carriers for drug and gene delivery to enhance cargo release in cellules. | Ce Tian 凌君 You-qing Shen | 2015 | Chinese Journal of Polymer Science2015，33，8： | 1 |
| 15 | Primary mesonephric adenocarcinoma of the fallopian tube:A case report显示文摘BACKGROUND Mesonephric adenocarcinoma(MNAC)is an extremely rare malignancy in the female genital tract.Only a few cases have been reported in the literature,and most of them occurred in the cervix,with extremely rare cases in the uterine body and ovary.MNAC has never been reported to arise in the fallopian tube.CASE SUMMARY A 45-year-old woman was referred to our institution with a history of abdominal pain.Ultrasound revealed a cystic and solid mass in left adnexal region.The patient underwent complete staging surgery when intraoperative pathological examination demonstrated that the mass was malignant.The final histological and immunohistochemical results confirmed the diagnosis of MNAC originating from the fallopian tube.Then she received four cycles of combination chemotherapy with carboplatin plus paclitaxel.The tumor recurred with hepatic metastases 4 mo after initial surgery,and second resection of the tumors in the liver plus partial hepatectomy was performed.She was supplemented with five courses of a new combination chemotherapy with gemcitabine plus carboplatin,and there was no evidence of recurrence within the 22-mo follow-up period after the second surgery.CONCLUSION MNAC originating from the fallopian tube is an extremely rare and high malignancy with a poor prognosis.It can be very aggressive,even at early stage.Little is known about the clinical characteristics,pathological diagnosis,prognosis,and optimal management strategy of MNAC originating from the fallopian tube.Herein we report the first case of primary MNAC deriving from the fallopian tube. | Chuan Xie Yang-Mei Shen Qiu-He Chen Ce Bian | 2021 | World Journal of Clinical Cases2021，9，18： | 1 |
| 16 | Prognostic factors and outcomes after definitive treatment of female urethral cancer:a population-based analysis显示文摘 | CHAMP CE HEGARTY SE SHEN X | 2012 | Urology2012，80，2： | 1 |
| 17 | Regulatory T Cells inhibit stable contacts between CIM +T cells and dendritic ceils in vivo 显示文摘 | Tedokoro CE Shakhar G Shen S | 2006 | J Exp Med2006，203，3： | 1 |
| 18 | Numerical Simulation of Subsurface Radar for Detecting Buried Pipes显示文摘 | LIU CE SHEN LIANG C | 1991 | IEEE Transactions on Geoscience and Remote Sensing1991，29，5： | 1 |
| 19 | Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo显示文摘 | Tadokoro CE Shakhar G Shen S | 2006 | J Exp Med2006，203，： | 1 |
| 20 | Long-term effect of therapeutic laser photocoagulation on gene expression in the eye显示文摘 | Binz N Graham CE Simpson K Lai YK Shen WY Lai CM | 2006 | FASEB J2006，20，2： | 1 |
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