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| 1 | Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization显示文摘AIM:To evaluate the inhibitory effects of regorafenib(BAY 73-4506),a multikinase inhibitor,on corneal neovascularization(NV).METHODS:Thirty adult male Sprague-Dawley rats weighing 250-300 g,were used.Corneal NV was induced by NaOH in the left eyes of each rat.Following the establishment of alkali burn,the animals were randomized into five groups according to topical treatment.Group 1(n=6)received 0.9%NaCl,Group 2(n=6)received dimethyl sulfoxide,Group 3(n=6)received regorafenib 1 mg/mL,Group 4(n=6)received bevacizumab 5 mg/mL and Group 5(n=6)received 0.1%dexamethasone phosphate.On the 7d,the corneal surface covered with neovascular vessels was measured on photographs as the percentage of the cornea's total area using computer-imaging analysis.The corneas obtained from rats were semiquantitatively evaluated for caspase-3 and vascular endothelial growth factor by immunostaining.RESULTS:A statistically significant difference in the percent area of corneal NV was found among the groups(P<0.001).Although the Group 5 had the smallest percent area of corneal NV,there was no difference among Groups 3,4 and 5(P>0.005).There was a statistically significant difference among the groups in apoptotic cell density(P=0.002).The staining intensity of vascular endothelial growth factor in the epithelial and endothelial layers of cornea was significantly different among the groups(P<0.05).The staining intensity of epithelial and endothelial vascular endothelial growth factor was significantly weaker in Groups 3,4 and 5 thanin Groups 1 and 2.CONCLUSION:Topical administration of regorafenib 1mg/mL is partly effective for preventing alkali-induced corneal NV in rats. | Halil Ibrahim Onder Mesut Erdurmus Yasin Yücel Bucak Hüseyin Simavli Murat Oktay Ahmet Sahap Kukner | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 2 | Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering显示文摘 | BONETTI P O WILSON S H RODRIGUEZ-POR- CEL M | 2002 | J Am Coll Cardiol2002，40，： | 1 |
| 3 | Effect of fly ash and PVA fiber on microstructural damage and residual properties of engineered cementitious composites exposed to high temperatures 显示文摘 | YAHMARAN M ?ZBAY E YüCEL H | 2011 | J Mater Civ Eng2011，23，17： | 1 |
| 4 | Treat ment of osteonecrosis of femora head with imp lantation of autologous bone marrow cel s显示文摘 | Valerie G Jean H Cels OM | | 0，，： | 1 |
| 5 | The role of late-phase pulse inversion harmonic imaging in the detection of occult hepatic metastases显示文摘 | Gültekin S Yücel C Ozdemir H | | 0，，09： | 1 |
| 6 | Abdominal aorta intima media thickness in obese children显示文摘 | Yücel O Cevik H Kinik ST | 2013 | J Pediatr Endocrinol Metab2013，26，78： | 1 |
| 7 | Antioxidant responses of shoots and roots of lentil to NaCl-salinity stress显示文摘 | Ebru Bandeo?lu Füsun Eyido?an Meral Yücel Hüseyin Avni ?ktem | 2004 | Plant Growth Regulation2004，，1： | 1 |
| 8 | Removal of 137 Cs from aqueous solutions using different cationic forms of a natural zeolite : clinoptilolite 显示文摘 | ABUSAFA A Y CEL H | 2002 | Separation and Purification Technology2002，28，2： | 1 |
| 9 | Use of the 1001keVpeak of Pa-234 m daughter of U-238in measurement ofuranium concentration by HPGe gamma-ray spectrometry显示文摘 | Yücel H Cetiner M A Demirel H | 1998 | Nuclear Instruments and Methods in Physics ResearchA1998，413，： | 1 |
| 10 | Association of CFH Y402H polymorphism with both forms of advanced age-related macular degeneration in Turkish patients显示文摘 | Yücel D Yilmaz M Durukan A H | | 0，，03： | 1 |
| 11 | Endocan, a novel marker of endothelial dysfunction in patients with essential hypertension: Comparative effects of amlodipine and valsartan显示文摘 | Turgay Cel&inodot k Sevket Balta Murat Karaman Sey&inodot t Ahmet Ay Sa&inodot t Dem&inodot rkol Ceng&inodot z Ozturk Mustafa D&inodot nc H&inodot lm&inodot U. Unal M. Ilker Y&inodot lmaz Sel&inodot m K&inodot l&inodot c Gulcan Kurt A. Tas At& | 2015 | Blood Pressure2015，，1： | 1 |
| 12 | Determination of zeranol residues and the serum testosterone oestrogene and progesterone levels in lambs around Ankara region显示文摘 | BORAZAN G (O) KARAG(U)L H CEL(I)K S | 2007 | Ankara Univ Vet Fak Derg2007，54，： | 1 |
| 13 | Effect of Fly Ash and PVA Fiber on Microstructural Damage and Residual Properties of Engineered Cementitious Composites Exposed to High Tem- peratures显示文摘 | AHMARAN M OZBAY E Yt]CEL H | 2011 | Journal of Materials in Civil Engineering2011，23，12： | 1 |
| 14 | Usefulness of somatosensory and motor evoked potentials for lesion localization显示文摘 | Akgün H Yücel M Oz O | | 0，，03： | 1 |
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