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| 1 | Petrogenesis of early Yanshanian highly evolved granites in the Longyuanba area,southern Jiangxi Province:Evidence from zircon U-Pb dating,Hf-O isotope and whole-rock geochemistry显示文摘Early Yanshanian(Jurassic) granitoids are widespread in the Nanling Range,South China.Whereas large granitic batholiths commonly crop out in the center of the Nanling Range(corresponding geographically to the central and northern parts of Guangdong Province),many small stocks occur in the southern part of Jiangxi Province.Most of the small stocks are associated closely with economically significant rare-metal deposits(W,Sn,Nb,Ta).Here we report the results for biotite granites and two-mica granites from three Yanshanian stocks of the Longyuanba complex.LA-ICPMS U-Pb dating of zircon yields an age of 156.1±2.1 Ma for Xiaomubei biotite granite,and U-Pb zircon dating using SIMS yields an age of 156.7±1.2 Ma for Longyuanba-Chengjiang biotite granite and 156.4±1.3 Ma for Jiangtoudong two-mica granite.Biotite granites are silica-rich(SiO 2 =70%-79%),potassic(K 2 O/Na 2 O>1.9),and peraluminous(ASI=1.05-1.33).Associated samples are invariably enriched in Rb,Th,Pb and LREE,yet depleted in Ba,Nb,Sr,P and Ti,and their REE pattern shows a large fractionation between LREE and HREE((La/Yb) N =10.7-13.5) and a pronounced Eu negative anomaly(δEu=0.28-0.41).Two-mica granite samples are also silica-rich(SiO 2 =75%-79%),potassic(K 2 O/Na 2 O>1.2),and peraluminous(ASI=1.09-1.17).However,in contrast to the biotite granites,they are more enriched in Rb,Th,Pb and extremely depleted in Ba,Nb,Sr,P and Ti,and exhibit nearly flat((La/Yb) N =0.75-1.08) chondrite-normalized REE patterns characterized by strong Eu depletion(δEu=0.02-0.04) and clear tetrad effect(TE 1.3 =1.10-1.14).Biotite granites and two-mica granties have comparable Nd isotopic signatures,and their εNd(t) are concentrated in the 13.0 to 9.6 and 11.5 to 7.7 respectively.Their zircon Hf-O isotopes of both also show similarity(biotite granites:εHf(t)= 10.8-7.9,δ 18 O=7.98‰-8.89‰ and εHf(t)= 13.8 to 9.1,δ 18 O=8.31‰-10.08‰;two-mica granites:εHf(t)= 11.3 to 8.0,δ 18 O=7.91‰-9.77‰).The results show that both biotite and two-mica granites were derived mainly from sedimentary source rocks with a minor contribution from mantle-derived materials.In spite of some S-type characteristics,the biotite granites were formed by fractional crystallization of I-type magma and assimilation of peraluminous sedimentary rocks during their ascent to the surface.Therefore,they belong to highly fractionated I-type granites.Two-mica granites exhibit a tetrad effect in their REE patterns,but share the same isotopic features with the biotite granites,suggesting that they are highly fractionated I-type granites as well.Their Lanthanide tetrad effects may be attributed to the hydrothermal alteration by magmatic fluids that have suffered degassing at late stages.Granitic magmas undergoing fractional crystallization and wall-rock assilimation can generate highly evolved granites with no REE tetrad effect in the uni-phase system.However,in the late-stage of magmatic evolution in the multi-phase system(i.e.,magmatic-hydrothermal system),these magmas also can lead to the highly evolved granites exhibiting mew-shaped REE pattern characterized by tetrad effect as the consequence of melt-fluid and fluid-vapor fractionation,and the resultant autometasomatism.We thus suggest that the REE pattern exhibiting tetrad effect feature is an important indicator of rare metal mineralization in the early Yanshanian time in southern China,implying the metamorphism of the ore fluid. | TAO JiHua LI WuXian LI XianHua CEN Tao | 2013 | Science China Earth Sciences2013，56，6： | 26 |
| 2 | Temporal and Spatial Variations of Abundance of Phycocyaninand Phycoerythrin-Rich Synechococcus in Pearl River Estuary and Adjacent Coastal Area显示文摘Three surveys were carried out in Pearl River Estuary and adjacent coastal area in May, August, and November, 2013, to investigate the temporal and spatial variations of abundance of phycoerythrin-rich Synechococcus(PE-rich SYN) and phycocyanin-rich Synechococcus(PC-rich SYN). The effects of environmental factors on the alternation of the different Synechococcus groups were also elucidated. PE-rich SYN was detected in three surveys, whereas PC-rich SYN was detected in May and August, but not in November. The highest abundances of PE-rich SYN and PC-rich SYN were recorded in August and May, with mean values of 74.17×103 and 189.92×103 cells m L-1, respectively. From May to November, the relative abundance of PE-rich SYN increased, whereas that of PC-rich SYN declined. PE-rich and PC-rich SYN presented similar horizontal distributions with high abundance in the southern estuary in May, and in the western estuary in August. The abundances of PE-rich and PC-rich SYN were high at 27–32℃and salinity of 10–20. PC-rich SYN was not detected at < 24℃, and PC:PE-rich SYN decreased in abundance with salinity increase. When less than 20 mg L-1, suspended particulate matter(SPM) was helpful for Synechococcus growth. PE-rich SYN decreased in abundance when the concentration of dissolved inorganic nitrogen increased in May and November, and the concentration of phosphate increased in November. However, PC-rich SYN abundance and nutrients showed no correlation. Principal component analysis and regression analysis indicated that PE-rich SYN significantly correlated with the principal components that were affected by environmental factors. | JIANG Tao CHAI Chao WANG Jifang ZHANG Ling CEN Jingyi LU Songhui | 2016 | Journal of Ocean University of China2016，15，5： | 6 |
| 3 | Viscosity and aggregation structure of nanocolloidal dispersions显示文摘In this work,the effects of nanoparticle size,particle volume fraction and pH on the viscosity of silicon dioxide nanocolloidal dispersions are investigated.Both size and pH are found to significantly affect nanocolloid viscosity.Two models are used to study the effect of aggregate structure on the viscosity of the nanocolloidal dispersion.The fractal concept is introduced to describe the irregular and dynamic aggregate structure.The structure of aggregates,which is considered to play an important role in viscosity,is affected by both intermolecular and electrostatic forces.The particle interaction is primarily affected by particle distance and becomes stronger with decreasing particle size and increasing volume fraction.The aggregate structure is also affected by the pH of the solution.Studying the relationship between pH and zeta-potential shows that with the neutralization of charges on the particle surface and decreasing electrical repulsion force,the particle interaction becomes dominated by attractive forces and the aggregates form a more compact structure. | WANG Tao NI MingJiang LUO ZhongYang SHOU ChunHui CEN KeFa | 2012 | Chinese Science Bulletin2012，57，27： | 4 |
| 4 | Real-time Performance Evaluation of Line Topology Switched Ethernet显示文摘Recently, switched Ethernet has become an active area of research because of its wide uses in industry. However, its uses have various real-time constraints on data communications. This paper analyzes the performance of the line topology switched Ethernet as a data acquisition network. Network calculus theory, which has been successfully applied to assess the real-time performance of packet-switched networks, is used to analyze the networks. To properly describe the activity of switches, a novel approach of modeling data flows into or out of switches is addressed. Based on our model, a concisely analytical expression of the maximal end-to-end delay in line topology switched Ethernet is derived. Finally, the relative simulation results are demonstrated. These results agree well with the analytical results, and thus they validate the data flow modeling techniques. | Fan Cen~* Tao Xing Ke-Tong Wu Institute of Acoustics, the Chinese Academy of Sciences, Beijing 100190, PRC | 2008 | International Journal of Automation and computing2008，5，4： | 4 |
| 5 | Mineralogical feature and geological significance of muscovites from the Longyuanba Indosinian and Yanshannian two-mica granites in the eastern Nanling Range显示文摘Emplacement P-T condition estimations using granites are important for understanding metamorphic and erosional processes of orogenic belt.Granites are widespread in South China and a majority of them are peraluminous.Particularly,over 91%of the Indosinian granites exposed in the region are peraluminous in composition.It is extremely hard to determine the pressure of intrusion of these peraluminous granites due to the absence of amphibole,a good mineral barometer commonly identified in metaluminous granites.Muscovite is a common mineral in peraluminous granites,certain kind of it could be used as a mineral barometer to constrain the emplacement pressure of peraluminous granites.In this paper,results of petrographic and geochemical studies of muscovites from the Indosinian and early Yanshanian two-mica granites at the Longyuanba in the eastern Nanling Range are reported.Based on petrographic studies,the primary muscovite can be discriminated from the secondary muscovites.Muscovites from the Indosinian two-mica granites are enriched in Ti,Al,Mg,and Na,and depleted in Fe and Mn.Geochemically,these muscovites were considered as primary,whereas those from the Yanshanian two-mica granites fall into the area of secondary muscovite on discrimination diagrams.Barometer estimations show that pressures calculated for primary muscovites are accurate,but those calculated for secondary muscovites are overestimated.The average pressure of emplacement of the Longyuanba Indosinian two-mica granites is 5.9 kbar,corresponding to^19 km in depth,suggesting that the Indosinian granitic magmas were probably generated by partial melting of a thickened crust root in a compressional tectonic setting. | TAO JiHua LI WuXian CAI YuanFeng CEN Tao | 2014 | Science China Earth Sciences2014，57，6： | 3 |
| 6 | Differentially Expressed microRNAs as Potential Markers for Vital Reaction of Burned Skin显示文摘The identification of antemortem burns and postmortem burns is essential in forensic practice.In this study,microRNA(miRNA)microarray analysis was conducted to identify differentially expressed miRNAs in the skin of an experimental burn model.Microarray analysis revealed 24 differentially expressed miRNAs in antemortem burned mice skin,with 19 miRNAs significantly upregulated and 5 downregulated.Based on the intersection predicted using three databases(Targetscan,microRNA.org,and PITA),293 potential miRNA targets were identified.These dysregulated miRNAs and their predicted targets were further analyzed using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases.Several functional categories and signaling pathways were enriched,including the“fc epsilon ri signaling pathway,”“endometrial cancer,”and“mTOR signaling pathway.”Expression patterns of 10 differentially expressed miRNAs were verified by reverse transcription‑quantitative polymerase chain reaction in mice skins.The results agreed with the results of microarray analysis.These findings suggest that differentially expressed miRNAs revealed by microarray are potential markers for forensic molecular diagnosis of antemortem burns. | Hao‑Pin Lyu Ming Cheng Jin‑Cen Liu Ming‑Yuan Ye Di Xu Jie‑Tao He Xiao‑Li Xie Qi Wang | 2018 | Journal of Forensic Science and Medicine2018，4，3： | 2 |
| 7 | Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase显示文摘Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) has become one major threat to human population health.The RNA-dependent RNA polymerase(RdRp) presents an ideal target of antivirals,whereas nucleoside analogs inhibitor is hindered by the proofreading activity of coronavirus.Herein,we report that corilagin(RAI-S-37) as a non-nucleoside inhibitor of SARS-CoV-2 RdRp,binds directly to RdRp,effectively inhibits the polymerase activity in both cell-free and cell-based assays,fully resists the proofreading activity and potently inhibits SARS-CoV-2 infection with a low 50% effective concentration(EC50) value of 0.13 μmol/L.Computation modeling predicts that RAI-S-37 lands at the palm domain of RdRp and prevents conformational changes required for nucleotide incorporation by RdRp.In addition,combination of RAI-S-37 with remdesivir exhibits additive activity against antiSARS-CoV-2 RdRp.Together with the current data available on the safety and pharmacokinetics of corilagin as a medicinal herbal agent,these results demonstrate the potential of being developed into one of the much-needed SARS-CoV-2 therapeutics. | Quanjie Li Dongrong Yi Xiaobo Lei Jianyuan Zhao Yongxin Zhang Xiangling Cui Xia Xiao Tao Jiao Xiaojing Dong Xuesen Zhao Hui Zeng Chen Liang Lili Ren Fei Guo Xiaoyu Li Jianwei Wang Shan Cen | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 2 |
| 8 | Synthesis and characterization of a sensitive and selective Fe^(3+) fluorescent sensor based on novel sulfonated calix[4]arene-based host-guest complex显示文摘A novel fluorescent sensor was prepared from sulfonated calix[4]arene(SC4A)by the host-guest com-plexation method using the fluorescent dye rhodamine B(RB)as a structure-directing agent.The crystal structure of the host-guest complex(RB@(SC4A)_(3))was confirmed by X-ray diffraction studies while its performance and sensing mechanism for metal ion pollutants were characterized using fluorescence and nuclear magnetic resonance spectroscopies.The results showed that RB@(SC4A)_(3) had a triangular branch structure resulting from host-guest mediation of the interactions between the three SC4A host molecules and the three terminal groups of the guest molecule RB.The host-guest complex exhibited sensitive and selective sensing towards Fe^(3+)ions via a fluorescence quenching mechanism.The results indicated that RB@(SC4A)_(3) could be a promising sensitive and selective fluorescent sensor for metal ion pollutants mon-itoring.It also provided new insights into the synthesis of calixarene-based host-guest complex. | Ran Cen Ming Liu Jihong Lu Weifang Zhang Jingjing Dai Xi Zeng Zhu Tao Xin Xiao | 2022 | Chinese Chemical Letters2022，33，5： | 2 |
| 9 | Etiology of newborn hearing impairment in Guangdong province: 10-year experience with screening, diagnosis, and follow-up显示文摘Background Hearing impairment is one of the most common birth defects in children.Universal newborn hearing screenings have been performed for 19 years in Guangdong province,China.A screening/diagnosis/intervention system has gradually been put in place.Over the past 10 years,a relatively complete data management system had been established.In the present study,an etiological analysis of newborn cases that failed the initial and follow-up screenings was performed.Methods The nature and degree of hearing impairment in newborns were confirmed by a set of procedures performed at the time of initial hearing screening,rescreening and final hearing diagnosis.Then,multiple examinations were performed to explore the associated etiology.Results Over a period of 10 years,720 children were diagnosed with newborn hearing loss.Among these children,445 (61.81%) children had a clearly identified cause,which included genetic factor(s) (30.56%),secretory otitis media (13.30%),maternal rubella virus infection during pregnancy (5.83%),inner ear malformations (4.86%),maternal human cytomegalovirus infection during pregnancy (2.92%),malformation of the middle ear ossicular chain (2.50%) and auditory neuropathy (1.81%).In addition,275 cases of sensorineural hearing loss of unknown etiology accounted for 38.19% of the children surveyed.Conclusions Long-term follow-up is needed to detect delayed hearing impairment and auditory development in children.The need for long-term follow-up should be taken into account when designing an intervention strategy.Furthermore,the use of the deafness gene chip should further elucidate the etiology of neonatal hearing impairment. | Bi-Xing Fang Jin-Tian Cen Tao Yuan Gen-Di Yin Jing Gu Shu-Qi Zhang Zhi-Cheng Li Yin-Fei Liang Xiang-Li Zeng | 2020 | World Journal of Pediatrics2020，16，3： | 2 |
| 10 | HZ08,a great regulator to reverse multidrug resistance via cycle arrest and apoptosis sensitization in MCF-7/ADM显示文摘 | Cen J Qi Y Tao Y F | | 0，，1： | 1 |
| 11 | HZ08 ,a great regulator to reverse multidrug resistance via cycle arrest and apoptosis sensitization in MCF-7/ADM显示文摘 | CEN J YAN Q TAO YF | 2010 | Eur J Pharmacol2010，647，123： | 1 |
| 12 | HZ08, a great regulator to reverse multidrug resistance via cycle arrest and apoptosis sensitization in MCF-7/ADM 显示文摘 | Cen J Qi Y Tao Y F | 2010 | Eur JPharmacol2010，647，13： | 1 |
| 13 | Filtration combustion characteristicsof low calorific gas in SIC foams 显示文摘 | Zheng CKenghuang? Cheng Leming Li Tao LuoZhongyang Cen Kefa | 2010 | Fuel2010，89，： | 1 |
| 14 | A hybrid-stress element based on Hamilton principle显示文摘A novel hybrid-stress finite element method is proposed for constructing simple 4-node quadrilateral plane elements,and the new element is denoted as HH4-3β here.Firstly,the theoretical basis of the traditional hybrid-stress elements,i.e.,the Hellinger-Reissner variational principle,is replaced by the Hamilton variational principle,in which the number of the stress variables is reduced from 3 to 2.Secondly,three stress parameters and corresponding trial functions are introduced into the system equations.Thirdly,the displacement fields of the conventional bilinear isoparametric element are employed in the new models.Finally,from the stationary condition,the stress parameters can be expressed in terms of the displacement parameters,and thus the new element stiffness matrices can be obtained.Since the required number of stress variables in the Hamilton variational principle is less than that in the Hellinger-Reissner variational principle,and no additional incompatible displacement modes are considered,the new hybrid-stress element is simpler than the traditional ones.Furthermore,in order to improve the accuracy of the stress solutions,two enhanced post-processing schemes are also proposed for element HH4-3β.Numerical examples show that the proposed model exhibits great improvements in both displacement and stress solutions,implying that the proposed technique is an effective way for developing simple finite element models with high performance. | Song Cen Tao Zhang Chen-Feng Li Xiang-Rong Fu Yu-Qiu Long | 2010 | Acta Mechanica Sinica2010，26，4： | 1 |
| 15 | Optimal design of the separate type heat pipe heat exchanger 显示文摘 | YUZi- tao HU Ya- cai CEN Ke- fa | 2005 | Journal of Zhe- jiang University: Science A2005，6，： | 1 |
| 16 | HZ08, a great regulator to reverse mul- tidrug resistance via cycle arrest and apoptosis sensitization in MCF-7/ ADM显示文摘 | Cen J Qi Y Tao Y F | 2010 | EurJPharmaeol2010，647，13： | 1 |
| 17 | HZ08, a great regulator to reverse multidrug resistance via cycle arrest and apop- tosis sensitization in MCF-7/ADM 显示文摘 | Cen J Qi Y Tao YF | 2010 | Eur J Pharmaeol2010，647，1： | 1 |
| 18 | Optimal de- sign of the separate type heat pipe heat exchanger显示文摘 | YU Zi- tao HU Ya- cai CEN Ke- fa | 2005 | JOUR- NAL OF ZHEJIANG UNIVERSITY SCIENCE A2005，6，1： | 1 |
| 19 | Physical exercise improves learning by modulating hippocampal mossy fiber sprouting and related gene expression in a developmental rat model of penicillin-induced recurrent epilepticus显示文摘 | Hong Ni Chao Li Lu-yuang Tao Jian-nong Cen | 2009 | Toxicology Letters2009，，1： | 1 |
| 20 | High performance Ga N-based hybrid white micro-LEDs integrated with quantum-dots显示文摘Hybrid white micro-pillar structure light emitting diodes(LEDs)have been manufacture utilizing blue micro-LEDs arrays integrated with 580 nm CIS((CuInS2-ZnS)/ZnS)core/shell quantum dots.The fabricated hybrid white micro-LEDs have good electrical properties,which are manifested in relatively low turn-on voltage and reverse leakage current.High-quality hybrid white light emission has been demonstrated by the hybrid white micro-LEDs after a systemic optimization,in which the corresponding color coordinates are calculated to be(0.3303,0.3501)and the calculated color temperature is 5596 K.This result indicates an effective way to achieve high-performance white LEDs and shows great promise in a large range of applications in the future including micro-displays,bioinstrumentation and visible light communication. | Feifan Xu Xu Cen Bin Liu Danbei Wang Tao Tao Ting Zhi Qi Wang Zili Xie Yugang Zhou Youdou Zheng Rong Zhang | 2020 | Journal of Semiconductors2020，41，3： | 0 |
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