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| 1 | The Duffy-binding-like domain 1 of PfEMP1 is a heparan sulfate ligand that requires 12 mers for binding显示文摘 | Antonio B Victor F Vi Chen Q | 2000 | Blood2000，95，11： | 1 |
| 2 | Developmental expression of a novel murine homeobox gene (Chxl0) :evidence for roles in determination of the neuroretina and inner nuclear layer 显示文摘 | Liu IS Chen JD Ploder L Vidgen D van der Kooy D Kalnins VI | 1994 | Neuron1994，13，2： | 1 |
| 3 | PCNA interacts wi- th Proxl and represses its transcriptional activity显示文摘 | Chen X Patel TP Simirskii VI | 2008 | Mol V/s2008，14，： | 1 |
| 4 | Study on the application of lnternet of Things in the logistics in forest industry 显示文摘 | Chen Zhao Vi Shengli Jun Songchen | 2011 | Applied Mechanics and Materials2011，，97： | 1 |
| 5 | Chromatin-associated SUMOylation controls the transcriptional switch between plant development and heat stress responses显示文摘The post-translational protein modification known as SUMOylation has conserved roles in the heat stress responses of various species.The functional connection between the global regulation of gene expression and chromatin-associatedSUMOylation in plant cells isunknown.Here,weuncovereda genome-wide relationship between chromatin-associated SUMOylation and transcriptional switches in Arabidopsis thaliana grown at room temperature,exposed to heat stress,and exposed to heat stress followed by recovery.The small ubiquitin-like modifier(SUMO)-associated chromatin sites,characterized by whole-genome ChIP-seq,were generally associated with active chromatin markers.In response to heat stress,chromatin-associated SUMO signals increased at promoter-transcriptional start site regions and decreased in gene bodies.RNAseq analysis supported the role of chromatin-associatedSUMOylation in transcriptional activation during rapid responses to high temperature.Changes inSUMOsignals on chromatinwere associated with the upregulation of heat-responsivegenesandthedownregulation ofgrowth-relatedgenes.Disruption of theSUMOligasegene SIZ1 abolished SUMOsignals on chromatin and attenuated rapid transcriptional responses to heat stress.The SUMO signal peaks were enriched in DNA elements recognized by distinct groups of transcription factors under different temperature conditions.These observations provide evidence that chromatin-associated SUMOylation regulates the transcriptional switch between development and heat stress response in plant cells. | Danlu Han Chen Chen Simin Xia Jun Liu Jie Shu Vi Nguyen Jianbin Lai Yuhai Cui Chengwei Yang | 2021 | Plant Communications2021，2，1： | 1 |
| 6 | A in Taiwan o r pilot study for by nucleic acid detecting occult hepatitis sing the us显示文摘 | Li L Chen P J Chen M screening blood donors amplification technology B virus infections and cl period for hepatitis C vi 48(6):1198-1206 H | 2008 | T serologic window ransfusion2008，，： | 1 |
| 7 | Existence of periodic solutions of p(t)-Laplacian systems显示文摘 | ZHANG Liang CHEN Vi | 2012 | Bull Malays Math Sci Soc2012，35，1： | 1 |
| 8 | Overpression ofc - met protein in Iwman thyroid tumor cxmrelateywith lymphnoye metastasis any cainicxrpatlu logic stage显示文摘 | Chen BIB Oiusnki Y Fnrihate VI | 1999 | Pathol Res P1999，195，6： | 1 |
| 9 | Intestinal re- modelling in mink fed with reduced protein content 显示文摘 | Chen P M Zhao J B Vi vi HunnickeN | 2009 | Journal of Biomechanics2009，，42： | 1 |
| 10 | 查看详情显示文摘 | WAN Vi LIN Zhang-bi CHEN Qi-dan | | 0，，03： | 1 |
| 11 | Non-destructive mea- surement of sugar content of apple using hyperspectral imaging technique 显示文摘 | ZHAO J VI'ITAYAPADUNGS CHEN Q | 2009 | Maejo International Journal of Science and Technology2009，3，1： | 1 |
| 12 | Epsin is an EH-domain-binding protein implicated in clathrin- mediated endocytosis 显示文摘 | Chen H Fre S Slepnev VI | 1998 | Nature1998，，6695： | 1 |
| 13 | Structure-activity relationship of pyrazol-4-ylpyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4显示文摘There is an accumulating body of evidence implicating the muscarinic acetylcholine receptor4(M4)in schizophrenia and dementia with Lewy bodies,however,a clinically validated M4positron emission tomography(PET)radioligand is currently lacking.As such,the aim of this study was to develop a suitable M4PET ligand that allows the non-invasive visualization of M4in the brain.Structure-activity relationship studies of pyrazol-4-yl-pyridine derivates led to the discovery of target compound 12—a subtype-selective positive allosteric modulator(PAM).The radiofluorinated analogue,[18F]12,was synthesized in 28±10%radiochemical yield,>37 GBq/μmol and an excellent radiochemical purity>99%.Initial in vitro autoradiograms on rodent brain sections were performed in the absence of carbachol and showed moderate specificity as well as a low selectivity of[18F]12 for the M4-rich striatum.However,in the presence of carbachol,a significant increase in tracer binding was observed in the rat striatum,which was reduced by>60%under blocking conditions,thus indicating that orthosteric ligand interaction is required for efficient binding o f[18F]12 to the allosteric site.Remarkably,however,the presence of carbachol was not required for high specific binding in the non-human primate(NHP)and human striatum,and did not further improve the specificity and selectivity of[18F]12 in higher species.These results pointed towards significant species-differences and paved the way for a preliminary PET study in NHP,where peak brain uptake of[18F]12 was found in the putamen and temporal cortex.In conclusion,we report on the identification and preclinical development of the first radiofluorinated M4PET radioligand with promising attributes.The availability of a clinically validated M4PET radioligand harbors potential to facilitate drug development and provide a useful diagnostic tool for non-invasive imaging. | Ahmed Haider Xiaoyun Deng Olivia Mastromihalis Stefanie K.Pfister Troels E.Jeppesen Zhiwei Xiao Vi Pham Shaofa Sun Jian Rong Chunyu Zhao Jiahui Chen Yinlong Li Theresa R.Connors April T.Davenport James B.Daunais Vahid Hosseini Wenqing Ran Arthur Christopoulos Lu Wang Celine Valant Steven H.Liang | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 0 |
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