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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Trogocytosis of CD80 and CD86 by induced regulatory 7 cells显示文摘 | Peng Gu Julia Fang Gao Cheryl A D'Souza Aleksandra Kowalczyk Kuang-Yen Chou Li Zhang | 2012 | Cellular & Molecular Immunology2012，9，2： | 7 |
| 3 | Gynecologic oncologists involvement on ovarian cancer standard of care receipt and survival显示文摘AIM:To examine the influence of gynecologic oncolo-gists(GO) in the United States on surgical/chemotherapeutic standard of care(SOC), and how this translates into improved survival among women with ovarian cancer(OC).METHODS: Surveillance, Epidemiology, and End Result(SEER)-Medicare data were used to identify 11688 OC patients(1992-2006). Only Medicare recipients with an initial surgical procedure code(n = 6714) were included. Physician specialty was identified by linking SEER-Medicare to the American Medical Association Masterfile. SOC was defined by a panel of GOs. Multivariate logistic regression was used to determine predictors of receiving surgical/chemotherapeutic SOCand proportional hazards modeling to estimate the effect of SOC treatment and physician specialty on survival. RESULTS: About 34% received surgery from a GO and 25% received the overall SOC. One-third of women had a GO involved sometime during their care. Women receiving surgery from a GO vs non-GO had 2.35 times the odds of receiving the surgical SOC and 1.25 times the odds of receiving chemotherapeutic SOC(P < 0.01). Risk of mortality was greater among women not receiving surgical SOC compared to those who did [hazard ratio = 1.22(95%CI: 1.12-1.33), P < 0.01], and also was higher among women seen by non-GOs vs GOs(for surgical treatment) after adjusting for covariates. Median survival time was 14 mo longer for women receiving combined SOC. CONCLUSION: A survival advantage associated with receiving surgical SOC and overall treatment by a GO is supported. Persistent survival differences, particularly among those not receiving the SOC, require further investigation. | Sun Hee Rim Shawn Hirsch Cheryll C Thomas Wendy R Brewster Darryl Cooney Trevor D Thompson Sherri L Stewart | 2016 | World Journal of Obstetrics and Gynecology2016，5，2： | 3 |
| 4 | Extracellular superoxide dismutase in biology and medicine 显示文摘 | Cheryl L Fattman Lisa M Schaefer Tim D Oury | 2003 | Free Radical Biology & Medicine2003，35，3： | 1 |
| 5 | Supportive-expressive group therapy and distress in patients with metastatic breast cancer: A randomized clinical intervention trial 显示文摘 | Catherine Classen Lisa D Butler Cheryl Kcopllmn | 2001 | Archives of Genneral Psychiatry Chicago2001，58，5： | 1 |
| 6 | Theoretical and Empirical Underpinnings of Parent-Child Interaction Therapy With Child Physical Abuse Population显示文摘 | Amy D Herschell Cheryl B McNeil | 2005 | Education and Treatment of Children2005，28，2： | 1 |
| 7 | Genetic engineering of fibrousproteins: spider dragline silk and collagen显示文摘 | CHERYL W P F KAPLAN D L | 2002 | Advanced Drug DeliveryReviews’2002，54，11： | 1 |
| 8 | Training foster parents in parent-child interaction therapy显示文摘 | Cheryl B McNeil Amy D Herschell Robin H Gurwitch | 2005 | Education and Treatment of Children2005，28，2： | 1 |
| 9 | Nicotine concentrations with electronic cigarette use: effects of sex and flavor显示文摘 | Cheryl A Oncken Mark D Litt Lynn D McLaughlin | 2015 | Nicotine and Tobacco Research2015，17，4： | 1 |
| 10 | MicroRNA expression and identification of putative miRNA targets in ovarian cancer 显示文摘 | Neetu D Cheryl A Tian L | 2008 | PLoS ONE2008，3，6： | 1 |
| 11 | Autism spectrum disorders in infancy and toddlerhood:A review of the evidence on early signs,early identification tools,and early diagnosis显示文摘 | Josephine B Cheryl D | | 0，，05： | 1 |
| 12 | Organochlorine insecticides, polychlorinated biphenyls, and metals in water, sediment, and green frogs from southwestern Michigan 显示文摘 | Gilliland Carolyn D Cheryl L S | 2001 | Chemosphere2001，44，3： | 1 |
| 13 | What Is the Functional Significance of Chronic Stress-Induced CA3Dendritic Retraction Within the Hippocampus?显示文摘 | Cheryl D Conrad | 2006 | Behavioral and Cognitive Neuroscience Reviews2006，5，1： | 1 |
| 14 | Getting out of a paper jam显示文摘 | Cheryl D C | 2001 | AmericanPrinter2001，7，： | 1 |
| 15 | Guidelines for the primary prevention ofstroke:a guideline for healthcare professionals from the American Heart Associ-ation/American Stroke Association显示文摘 | Larry B Goldstein Cheryl D | 2011 | Stroke2011，42，2： | 1 |
| 16 | Adhesion strength measurement of polymer dielectric interfaces us- ing laser spallation technique 显示文摘 | SOMA SEKHAR V KANDULA CHERYL D HART- FIELD PHILIPPE H GEUBELLE | 2008 | Thin Solid Films2008，516，21： | 1 |
| 17 | Extracellular superoxide dismutase in biology and medicine显示文摘 | Cheryl L Fattman Lisa M Schaefer Tim D Oury | 2003 | Free Radical Biology and Medicine2003，，3： | 1 |
| 18 | Genetic diversity at an oncogene locus and in mitochondrial DNA between populations of cancer-prone atlantic tomcod显示文摘 | Isaac I. Wirgin Matthew D’Amore Cheryl Grunwald Adam Goldman Seymour J. Garte | 1990 | Biochemical Genetics (-)1990，，9： | 1 |
| 19 | Immunization of mice with DNAbased Pfs25 elicits potent malaria transmission-blocking antibodies显示文摘 | Cheryl AL Ravi D Nirbhay K | 1999 | Infect Immun1999，67，4： | 1 |
| 20 | Guidelines for the primary prevention of stroke显示文摘 | Larry B Cheryl D Robert J | | 0，，02： | 1 |
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