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| 1 | The structural and accessory proteins M,ORF 4a,ORF 4b,and ORF 5 of Middle East respiratory syndrome coronavirus(MERS-CoV)are potent interferon antagonists显示文摘The newly emerged Middle East respiratory syndrome coronavirus(MERS-CoV)is a highly pathogenic respira-tory virus with pathogenic mechanisms that may be driven by innate immune pathways.The goal of this study is to characterize the expression of the structural(S,E,M,N)and accessory(ORF 3,ORF 4a,ORF 4b,ORF 5)proteins of MERS-CoV and to determine whether any of these pro-teins acts as an interferon antagonist.Individual structural and accessory protein-coding plasmids with an N-terminal HA tag were constructed and transiently transfected into cells,and their native expression and subcellular localiza-tion were assessed using Wes tern blotting and indirect immunofl uorescence.While ORF 4b demonstrated majorly nuclear localization,all of the other proteins demonstrated cytoplasmic localization.In addition,for the fi rst time,our experiments revealed that the M,ORF 4a,ORF 4b,and ORF 5 proteins are potent interferon antagonists.Further exami-nation revealed that the ORF 4a protein of MERS-CoV has the most potential to counteract the antiviral effects of IFN via the inhibition of both the interferon production(IFN-βpromoter activity,IRF-3/7 and NF-κB activation)and ISRE promoter element signaling pathways.Together,our re-sults provide new insights into the function and pathogenic role of the structural and accessory proteins of MERS-CoV. | Yang Yang Ling Zhang Heyuan Geng Yao Deng Baoying Huang Yin Guo Zhengdong Zhao Wenjie Tan | 2013 | Protein & Cell2013，4，12： | 25 |
| 2 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 3 | Prevalence and molecular characteristics of Listeria monocytogenes in cooked products and its comparison with isolates from listeriosis cases显示文摘这研究试图在 Zigong 城市里在煮的产品调查流行和 Listeria monocytogenes 的分子的特征,中国。L 的全面出现。在商店和羊肉餐馆调查了的 ready-to-eat (RTE ) 的 monocytogenes 是 16.2%(141/873 ) 。13.5% 的出现在 RTE 猪肉被观察, 6.5% 在 RTE 蔬菜,并且非常, 24.0% 在也煮了羊肉或煮了将羊杂切碎加麦片纳入羊胃中煮成的食物。Serotype 1/2b (45.4%) , 1/2a (33.3%) ,和 1/2c (14.2%) 是占优势的类型。由基于 L 的打字的 multilocus 顺序(MLST ) 比较同种细胞的建筑群(CC ) 。从从中国, CC87, CC9, CC8,和 CC3 的不同区域的 Zigong 城市和 33 个 listeriosis 案例里的煮的食物的 monocytogenes 被显示在煮的产品和 CC87 流行, CC3 是在 33 诊所来源紧张的开始的二种经常的类型。所有 CC87 污点怀有最新报导的 Listeria 致病力岛 4 (LIPI-4 ) 基因碎片 ptsA,和所有 CC3 紧张拥有了 Listeria 致病力岛 3 (LIPI-3 ) 基因碎片 llsX。这些可以增加在中国在 listeriosis 情况中属于 CC87 和 CC3 的紧张的出现并且也从 Zigong 由于煮的产品的消费加重感染的风险。ST619 (serotype 1/2b ) 怀有 llsX 和 ptsA,显示在 Zigong 的一种潜在的 hypervirulent 顺序类型。 | Hong Wang Lijuan Luo Zhengdong Zhang Jianping Deng Yan Wang Yimao Miao Ling Zhang Xi Chen Xiang Liu Songsong Sun Bo Xiao Qun Li Changyun Ye | 2018 | Frontiers of Medicine2018，12，1： | 9 |
| 4 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 5 | Effect of Laser Power on the Microstructure and Mechanical Properties of TiN/Ti_3Al Composite Coatings on Ti6Al4V显示文摘Laser nitriding is one of the effective techniques to improve the surface properties of titanium alloys and has potential application in the life extension of last-stage steam turbine blades. However, cracking of surface coating is a common problem due to heat concentration in laser nitriding process. Conventionally, the cracks can be avoided through heat treatment, which may have an important influence on the mechanical properties of coating. Crack-free TiN/Ti3Al IMC coatings on Ti6Al4V are prepared by plasma spraying and laser nitriding. The microstructures, phase constitutes and compositions of the coating are observed and analyzed with scanning electron microscopy(SEM), X-ray diffraction(XRD) and X-ray energy-dispersive spectroscopy(EDS). Microhardness, elastic modulus, fracture toughness of the coating are measured. The results show that the crackand pore-free IMC coatings can be made through the proposed method; with increasing laser power, the amount and density of TiN phase in the coating first increased and then decreased, leading to the similar trend of microhardness and elastic modulus and the reverse trend of fracture toughness of the coating. Both the average microhardness and elastic modulus of the coating increase three times higher than those of the substrate. The volume fraction of the TiN reinforced phase in composite can be controlled by varying the laser power and the cracking problem in laser nitriding process is successfully solved. | LIU Zhengdao ZHANG Xiancheng XUAN Fuzhen WANG Zhengdong TU Shandong | 2013 | Chinese Journal of Mechanical Engineering2013，26，4： | 6 |
| 6 | Radiofrequency ablation versus partial nephrectomy for the treatment of clinical stage 1 renal masses: a systematic review and meta-analysis显示文摘 | Wang Shangqian Qin Chao Peng Zhihang Cao Qiang Li Pu Shao Pengfei Ju Xiaobing Meng Xiaoxin Lu Qiang Li Jie Wang Meilin Zhang Zhengdong Gu Min Zhang Wei Yin Changjun | 2014 | Chinese Medical Journal2014，，13： | 5 |
| 7 | Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer显示文摘Curcumin (淫液) ,主要 polyphenolic curcuminoid,从沉金根茎姜黄 longa 获得了,最近被报导在 vitro 并且在 vivo 有潜在的 antitumor 效果。Docetaxel (文档) 为非小的房间肺癌症的治疗被认为化疗同样首要。这里,我们第一次报导淫液能 synergistically 提高在里面 vitro 并且在对肺癌症的文档的 vivo antitumor 功效。在当前的学习,联合索引(CI ) 在 vitro 并且在 vivo 研究是打算的在里面决定在淫液和文档之间的相互作用。在里面在里面 vitro cytotoxicity 测试,中等效果的分析清楚地在某些集中显示了在淫液和文档之间的一个 synergistic 相互作用。而且,在 vivo,评估进一步在确定的 A549 与由静脉内的交货独自一个的文档相比表明了淫液 + 文档的优异 anticancer 功效移植异种皮移植模型。结果证明淫液 synergistically 在 4 天起始的治疗以后立即增加了文档的功效。另外,淫液和文档的同时的管理几乎没在治疗学的剂量包括骨头髓和肝显示出很少毒性到正常纸巾。因此,在 vitro 并且在 vivo,评估在传统的化疗对肺癌症和淫液的介绍表明了淫液和文档的令人满意的 synergistic antitumor 功效是阻止非小的房间肺癌症的传播的一个很有希望的方法。 | Haitao Yin Rui Guo Yong Xu Yulong Zheng Zhibo Hou Xinzheng Dai Zhengdong Zhang Donghui Zheng Hua'e Xu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 4 |
| 8 | Classification of Imagined Speech EEG Signals with DWT and SVM显示文摘With the development of human-computer interaction technology,brain-computer interface(BCI)has been widely used in medical,entertainment,military,and other fields.Imagined speech is the latest paradigm of BCI and represents the mental process of imagining a word without making a sound or making clear facial movements.Imagined speech allows patients with physical disabilities to communicate with the outside world and use smart devices through imagination.Imagined speech can meet the needs of more complex manipulative tasks considering its more intuitive features.This study proposes a classification method of imagined speech Electroencephalogram(EEG)signals with discrete wavelet transform(DWT)and support vector machine(SVM).An open dataset that consists of 15 subjects imagining speaking six different words,namely,up,down,left,right,backward,and forward,is used.The objective is to improve the classification accuracy of imagined speech BCI system.The features of EEG signals are first extracted by DWT,and the imagined words are clas-sified by SVM with the above features.Experimental results show that the proposed method achieves an average accuracy of 61.69%,which is better than those of existing methods for classifying imagined speech tasks. | ZHANG Lingwei ZHOU Zhengdong XU Yunfei JI Wentao WANG Jiawen SONG Zefeng | 2022 | Instrumentation2022，9，2： | 4 |
| 9 | An overview on GNSS carrier-phase time transfer research显示文摘Global navigation satellite system(GNSS)carrier phase observations are two orders of higher accuracy than pseudo-range observations,and they are less affected by multipath besides.As a result,the time transfer accuracy can reach 0.1 ns,and the frequency transfer stability can reach 1×10^-15 with carrier phase(CP)method,therefore CP method is considered the most accurate and promising time transfer technology.The focus of this paper is to present a comprehensive summary of CP method,with specific attention directed toward day-boundary clock jump,ambiguity resolution(AR),multi-system time transfer and real-time time transfer.Day-boundary clock jump is essentially caused by pseudo-range noise.Several approaches were proposed to solve the problem,such as continuously processing strategy,sliding batch and bidirectional filtering methods which were compared in this study.Additionally,researches on AR in CP method were introduced.Many scholars attempted to fix the single-difference ambiguities to improve the time transfer result,however,owing to the uncalibrated phase delay(UPD)was not considered,the current studies on AR in CP method were still immature.Moreover,because four GNSS systems could be used for time-transfer currently,which was helpful to increase the accuracy and reliability,the researches on multi-system time transfer were reviewed.What’s more,real-time time transfer attracted more attention nowadays,the preliminary research results were presented. | ZHANG Ming Lü JinHu BAI ZhengDong JIANG ZhiQi CHEN BoBo | 2020 | Science China(Technological Sciences)2020，63，4： | 3 |
| 10 | Bladder cancer epidemiology and genetic susceptibility显示文摘Bladder cancer is the most common malignancy of the urinary system. The incidence of bladder cancer of men is higher than that of women (approximately 4:1). Here, we summarize the bladder cancer-related risk factors, including environmental and genetic factors. In recent years, although the mortality rate induced by bladder cancer has been stable or decreased gradually, the public health effect may be pronounced. The well-established risk factors for bladder cancer are cigarette smoking and occupational exposure. Genetic factors also play important roles in the susceptibility to bladder cancer. A recent study demonstrated that hereditary non-polyposis colorectal cancer is associated with increased risk of bladder cancer. Since 2008, genome-wide association study (GWAS) has been used to identify the susceptibility loci for bladder cancer. Further gene-gene or gene-environment interaction studies need to be conducted to provide more information for the etiology of bladder cancer. | Haiyan Chu Meilin Wang Zhengdong Zhang | 2013 | The Journal of Biomedical Research2013，27，3： | 3 |
| 11 | The electromagnetically induced transparency in the Y-type four-level atom system at low light levels显示文摘In this paper a Y-type four-level atom interacting with external fields system is investigated. It is shown that increasing the control field can reduce the probe absorption, the electromagnetically induced transparency (EIT) and gain can be obtained if the parameters are taken appropriately. An interesting phenomenon is found that the system appears to be probe gain in a large region if the external fields Rabi phases are taken appropriately, too. | ZHANG Liying LIU Zhengdong CHEN Jun | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，5： | 3 |
| 12 | Experimental and mechanistic study on chemical looping combustion of caking coal显示文摘Under high-temperature batch fluidized bed conditions and by employing juye coal as the raw material,the present study determined the effects of the bed material,temperature,OC/C ratio,steam flow and oxygen carrier cycle on the chemical looping combustion of coal.In addition,the variations taking place in the surface functional groups of coal under different reaction times were investigated,and the variations achieved by the gas released under the pyrolysis and combustion of Juye coal were analyzed.As revealed from the results,the carbon conversion ratio and rate were elevated significantly,and the volume fraction of the outlet CO_(2)remained more than 92%under the oxygen carriers.The optimized reaction conditions to achieve the chemical looping combustion of Juye coal consisted of a temperature of 900℃,an OC/C ratio of 2,as well as a steam flow rate of 0.5 g·min^(-1).When the coal was undergoing the chemical looping combustion,volatiles primarily originated from the pyrolysis of aliphatic-CH_(3)and-CH_(2),and CO and H_(2)were largely generated from the gasification of aromatic carbon.In the CLC process,H_(2)O and CO_(2)began to separate out at 270℃,CH4 and tar began to precipitate at 370℃,and the amount of CO_(2)was continuously elevated with the rise of the temperature. | Xiuli Zhang Zhengdong Gao Yongzhuo Liu Yuanhao Hou Xiaoqing Sun Qingjie Guo | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 2 |
| 13 | Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer显示文摘 | Zhi Xu Haixia Zhu John M. Luk Dongmei Wu Dongying Gu Weida Gong Yongfei Tan Jianwei Zhou Jinhai Tang Zhengdong Zhang Meilin Wang Jinfei Chen | 2012 | Cancer2012，，22： | 2 |
| 14 | 0.5981μm Sum Frequency Mixing in KTP Crystal显示文摘Based on accurate values of refractive indices,the phase matching angles(θ_(m))and effective nonlinear coeficients(d_(eff))for type I and I I sum frequency mixing of 1.0795 and 1.3414μm radiations were calculated in KTP crystal.The optimum phase matching conditions are thatθm=75.74o in the XZ plane(Ф=0)and deff=17.42 × 10^(-9) esu.The calculated results agree well with the experimental results.Thus,the cw 0.5981μm sum frequency radiation was achieved in KTP crystal using a 1.0795 and 1.3414μm double-wavelength Nd:YAP cw laser. | SHEN Hongyuan ZHOU Yuping LIN Wenxiong ZENG Ruirong YU Guifang HUANG Chenghui ZENG Zhengdong ZHANG Weijia JIA Shouquan JIANG Peizhi XIAO Chaoliang | 1991 | Chinese Physics Letters1991，8，4： | 2 |
| 15 | Enrichment factors of movable hydrocarbons in lacustrine shale oil and exploration potential of shale oil in Gulong Sag,Songliao Basin,NE China显示文摘The geological characteristics and production practices of the major middle-and high-maturity shale oil exploration areas in China are analyzed.Combined with laboratory results,it is clear that three essential conditions,i.e.economic initial production,commercial cumulative oil production of single well,and large-scale recoverable reserves confirmed by the testing production,determine whether the continental shale oil can be put into large-scale commercial development.The quantity and quality of movable hydrocarbons are confirmed to be crucial to economic development of shale oil,and focuses in evaluation of shale oil enrichment area/interval.The evaluation indexes of movable hydrocarbon enrichment include:(1)the material basis for forming retained hydrocarbon,including TOC>2%(preferentially 3%-4%),and typeⅠ-Ⅱkerogens;(2)the mobility of retained hydrocarbon,which is closely related to the hydrocarbon composition and flow behaviors of light/heavy components,and can be evaluated from the perspectives of thermal maturity(Ro),gas-oil ratio(GOR),crude oil density,quality of hydrocarbon components,preservation conditions;and(3)the reservoir characteristics associated with the engineering reconstruction,including the main pore throat distribution zone,reservoir physical properties(including fractures),lamellation feature and diagenetic stage,etc.Accordingly,13 evaluation indexes in three categories and their reference values are established.The evaluation indicates that the light shale oil zones in the Gulong Sag of Songliao Basin have the most favorable enrichment conditions of movable hydrocarbons,followed by light oil and black oil zones,containing 20.8×10^(8) t light oil resources in reservoirs with R_(0)>1.2%,pressure coefficient greater than 1.4,effective porosity greater than 6%,crude oil density less than 0.82 g/cm^(3),and GOR>100 m/m^(3).The shale oil in the Gulong Sag can be explored and developed separately by the categories(resource sweet spot,engineering sweet spot,and tight oil sweet spot)depending on shale oil flowability.The Gulong Sag is the most promising area to achieve large-scale breakthrough and production of continental shale oil in China. | ZHAO Wenzhi BIAN Congsheng LI Yongxin ZHANG Jinyou HE Kun LIU Wei ZHANG Bin LEI Zhengdong LIU Chang ZHANG Jingya GUAN Ming LIU Shijul | 2023 | Petroleum Exploration and Development2023，50，3： | 2 |
| 16 | Study on the surface cracking in hot-rolled plates of Fe-23Mn-2Al-V austenitic steel显示文摘The study introduces the chemical composition,mechanical properties,physical properties and production processes of the Fe-23Mn-2Al-V austenitic steel.Investigations were made into the formation of cracks in the hot-rolled Fe-23Mn-2Al-V steel plates,with optical microscopy (OM),scanning electron microscopy (SEM) and energy dispersive spectrum (EDS).The results have shown that intergranular oxidation in the reheating furnace is the main cause of the cracks on the surface of the hot-rolled steel plates.The surface cracking can be largely avoided by controlling the remaining oxygen content in the reheating furnace and improving continuous casting (CC) processes to increase the thickness of fine equiaxed grain layer of the steel slabs. | LIAO Hongjun MAO Zhengdong WANG Lintao ZHU Jun LI Yuan ZHANG Heng | 2011 | Baosteel Technical Research2011，5，1： | 2 |
| 17 | Texture Repairing by Unified Low Rank Optimization显示文摘在这份报纸,我们显示出怎么为图象结束在常规或在常规附近的质地利用低等级、稀少的结构。我们的方法为随机、连续的贪污基于统一明确的表达。除了质地的低等级性质,算法也使用自然图象的稀少的假设:因为自然图象是 piecewise,变光滑,它在某些转变领域是稀少的(例如 Fourier 或小浪变换) 。我们联合低等级并且质地的稀少性质在建议算法一起想象。我们的算法能自动地并且正确地基于凸的优化修理一块贿赂质地的全球结构,甚至没有要完成的区域的精确信息。这个算法集成质地校正并且修理进一个优化问题。通过广泛的模拟,我们证明我们的方法能完成并且修理错误比存在低等级的矩阵恢复方法更好与随机、连续的支持贿赂的质地。我们的方法证明超越本地补丁的重要优点在处理大贪污,不一致的质地,和大观点变丑基于质地合成技术。 | Xiao Liang Xiang Ren Zhengdong Zhang Yi Ma | 2016 | Journal of Computer Science & Technology2016，31，3： | 2 |
| 18 | Ultralarge Rabi splitting and broadband strong coupling in a spherical hyperbolic metamaterial cavity显示文摘Strong coupling(SC) between two resonant plasmon modes can result in the formation of new hybrid modes exhibiting Rabi splitting with strong energy exchange at the nanoscale. However, normal Rabi splitting is often limited to ~50–320 me V due to the short lifetime of the plasmon mode. Here, we theoretically demonstrate a record Rabi splitting energy as large as 805 me V arising from the SC between the high-Q plasmonic whispering gallery mode and high-Q cavity plasmon resonance supported by a spherical hyperbolic metamaterial cavity,which consists of a dielectric nanosphere core wrapped in 7 alternating layers of silver/dielectric materials.In addition, the new hybrid modes formed by the SC are shown to exhibit an extralong lifetime of up to 71.9–81.6 fs, with the large electric field intensity enhancement at both the dielectric core and the dielectric layers. More importantly, the spectral ranges of SC can be tuned across an ultrabroad range from the visible to the near-IR by simply changing the dielectric core size. These findings may have potential applications in bright single-photon sources. | PING GU JING CHEN SIYU CHEN CHUN YANG ZUXING ZHANG WEI DU ZHENGDONG YAN CHAOJUN TANG ZHUO CHEN | 2021 | Photonics Research2021，9，5： | 2 |
| 19 | Cross-Modal Complementary Network with Hierarchical Fusion for Multimodal Sentiment Classification显示文摘Multimodal Sentiment Classification(MSC)uses multimodal data,such as images and texts,to identify the users'sentiment polarities from the information posted by users on the Internet.MSC has attracted considerable attention because of its wide applications in social computing and opinion mining.However,improper correlation strategies can cause erroneous fusion as the texts and the images that are unrelated to each other may integrate.Moreover,simply concatenating them modal by modal,even with true correlation,cannot fully capture the features within and between modals.To solve these problems,this paper proposes a Cross-Modal Complementary Network(CMCN)with hierarchical fusion for MSC.The CMCN is designed as a hierarchical structure with three key modules,namely,the feature extraction module to extract features from texts and images,the feature attention module to learn both text and image attention features generated by an image-text correlation generator,and the cross-modal hierarchical fusion module to fuse features within and between modals.Such a CMCN provides a hierarchical fusion framework that can fully integrate different modal features and helps reduce the risk of integrating unrelated modal features.Extensive experimental results on three public datasets show that the proposed approach significantly outperforms the state-of-the-art methods. | Cheng Peng Chunxia Zhang Xiaojun Xue Jiameng Gao Hongjian Liang Zhengdong Niu | 2022 | Tsinghua Science and Technology2022，27，4： | 2 |
| 20 | Machine-learning guided optimization of laser pulses for direct-drive implosions显示文摘The optimization of laser pulse shapes is of great importance and a major challenge for laser direct-drive implosions.In this paper,we propose an efficient intelligent method to perform laser pulse optimization via hydrodynamic simulations guided by the genetic algorithm and random forest algorithm.Compared to manual optimizations,the machine-learning guided method is able to efficiently improve the areal density by a factor of 63%and reduce the in-fiight-aspect ratio by a factor of 30%at the same time.A relationship between the maximum areal density and ion temperature is also achieved by the analysis of the big simulation dataset.This design method has been successfully demonstrated by the2021 summer double-cone ignition experiments conducted at the SG-II upgrade laser facility and has great prospects for the design of other inertial fusion experiments. | Fuyuan Wu Xiaohu Yang Yanyun Ma Qi Zhang Zhe Zhang Xiaohui Yuan Hao Liu Zhengdong Liu Jiayong Zhong Jian Zheng Yutong Li Jie Zhang | 2022 | High Power Laser Science and Engineering2022，10，2： | 2 |
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