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| 1 | Transdermal delivery of 4-aminopyridine accelerates motor functional recovery and improves nerve morphology following sciatic nerve crush injury in mice显示文摘Oral 4-aminopyridine(4-AP)is clinically used for symptomatic relief in multiple sclerosis and we recently demonstrated that systemic 4-AP had previously unknown clinically-relevant effects after traumatic peripheral nerve injury including the promotion of re-myelination,improvement of nerve conductivity,and acceleration of functional recovery.We hypothesized that,instead of oral or injection administration,transdermal 4-AP(TD-4-AP)could also improve functional recovery after traumatic peripheral nerve injury.Mice with surgical traumatic peripheral nerve injury received TD-4AP or vehicle alone and were examined for skin permeability,pharmacokinetics,functional,electrophysiological,and nerve morphological properties.4-AP showed linear pharmacokinetics and the maximum plasma 4-AP concentrations were proportional to TD-4-AP dose.While a single dose of TD-4-AP administration demonstrated rapid transient improvement in motor function,chronic TD-4-AP treatment significantly improved motor function and nerve conduction and these effects were associated with fewer degenerating axons and thicker myelin sheaths than those from vehicle controls.These findings provide direct evidence for the potential transdermal applicability of 4-AP and demonstrate that 4-AP delivered through the skin can enhance in-vivo functional recovery and nerve conduction while decreasing axonal degeneration.The animal experiments were approved by the University Committee on Animal Research(UCAR)at the University of Rochester(UCAR-2009-019)on March 31,2017. | Andrew RClark Chia George Hsu M A Hassan Talukder Mark Noble John CElfar | 2020 | Neural Regeneration Research2020，15，1： | 3 |
| 2 | Buffering in optical packet switches显示文摘 | D K Hunter M C Chia I Andonovic | 1998 | IEEE Journal of Lightwave Technology1998，16，12： | 2 |
| 3 | M onte Carlo方法研究支气管组织自体荧光光谱显示文摘在实验获得支气管组织显微荧光特性和有关光学特性参量的基础上 ,将支气管组织简化为三层光学模型 ,用 Monte Carlo方法模拟 44 2 nm He-Cd激光在组织模型中的光分布及自体荧光的逃逸函数 ,计算出各组织层对总体自体荧光的贡献 ,并模拟出逃逸到组织体表面的自体荧光光谱 .进一步实验测量与理论计算的自体荧光光谱比较表明 ,两者在 460~ 5 2 0 nm及60 0~ 70 0 | 郑蔚 黄志伟 谢树森 李涉洪 K rishnan S M Chia T C | 2001 | 光子学报2001，30，6： | 2 |
| 4 | Cobra cardiotoxin-induced cell death in fetal rat cardiomycoytes and cortical neurons:different pathway butsimilar cell surface target显示文摘 | Chia HW Robert M Shao C L | 2006 | Toxlcon2006，，46： | 1 |
| 5 | A genome-wide characterization of microRNA genes in maize 显示文摘 | Zhang L Chia J M Kumari S | 2009 | PEnS Genetics2009，5，10： | 1 |
| 6 | Photorefractive keratectomy in young Asian aviators with low-moderate myopia显示文摘 | See B Tan M Chia SE | 2014 | Avi- at Space Environ Med2014，85，1： | 1 |
| 7 | Protective effect of methyl gallate from Toona sinensis (Meliaceae) against hydrogen peroxide-induced oxidative stress and DNA damage in MDCK cells 显示文摘 | Hsieh T J Liu T Z Chia Y C Chern C L Lu F J Chuang M C Mau S Y Chen S H Syu Y H Chen C H | 2004 | Food and Chemical Toxicology2004，42，5： | 1 |
| 8 | Packet loss and delay performance of feedback and feed-forward arrayed-waveguide gratingsbased optical packet switches with WDM inputs显示文摘 | Chia M C Hunter D K Andonovic I | 2001 | IEEE J Light-wave Tectal2001，19，9： | 1 |
| 9 | Analysis and biological ac- tivities of anthocyanins显示文摘 | KONG J M CHIA L S GOH N K | 2003 | Phytochemistry2003，64，： | 1 |
| 10 | Evaluation of interface shear strength and residual stress of sol-gel derived fluoridated hydroxyapatite coatings on Ti6A14V substrates显示文摘 | ZHANG S WANG Y S ZENG X T CHENG K QIAN M SUN D E WENG W J CHIA W Y | | 0，，： | 1 |
| 11 | Analysis and biological activities of anthocyanins显示文摘 | Kong J M Chia L S Goh N K | 2003 | Phytochemistry2003，64，5： | 1 |
| 12 | Sesquiterpene dialdehydes inhibit MSU crystal-induced superoxide production by infiltrating neutrophils in an in vivo model of gouty inflammation 显示文摘 | Martin W J Herst P M Chia E W | 2009 | Free Rad Bio Med2009，47，5： | 1 |
| 13 | Tumor-targeted gene therapy for nasopharyngeal carcinoma显示文摘 | Li JH Chia M Shi W | 2002 | Cancer Res2002，62，1： | 1 |
| 14 | Immunogenieity of recombinant GP5 protein of porcine reproductive and respiratory syndrome virus expressed in tobacco plant显示文摘 | CHIA M Y HSIAO S H CHAN H T | 2010 | Veterinary Immunology and Immunopathology2010，135，34： | 1 |
| 15 | The effect of alloy composition on the microstructure and tensile properties of binary Mg-rare earth alloys 显示文摘 | Chia T L Easton M A Zhu S M | 2009 | Intermetallics2009，17，7： | 1 |
| 16 | Financial Crises and Interacting Heterogeneous Agents 显示文摘 | HUANG W H ZHENG H H CHIA W M | 2010 | Journal of Eco- nomic Dynamics and Control2010，34，6： | 1 |
| 17 | Interethnic variability of plasma paraoxonase (PON1) activity towards organophosphates and PON1 polymorphisms among Asian populations 显示文摘 | ALI S M CHIA S E | 2008 | Industrial Health2008，46，4： | 1 |
| 18 | Comparative analysis of the testis and ovary transcriptomes in zebrafish by com- bining experimental and computational tools 显示文摘 | Li Y Chia J M Bartfai R | 2004 | Compa- rative and Functional Genomics2004，5，40： | 1 |
| 19 | Broadband monopole antenna with parasitic planar element显示文摘 | CHEN Z N CHIA Y W M | 2000 | Microwave and Optical Technology Letters2000，27，3： | 1 |
| 20 | Analysis and biological activities of anthocyanins显示文摘 | KONG J M CHIA L S GOH N K | 2003 | Phytochemistry2003，64，： | 1 |
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