|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3显示文摘AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC model.RESULTS: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and metastasis.CONCLUSION: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation. | Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang JH, Huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. | 2011 | World Journal of Gastroenterology2011，17，34： | 18 |
| 2 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 3 | The Responsivity of the Bacteriorhodopsin Langmuir-Blodgett Film Intermittent Light显示文摘TheResponsivityoftheBacteriorhodopsinLangmuir-BlodgettFilmIntermittentLight￥GuangYuWANG;JianHuaYANG;ZhiGuangZHANG;ShuHuangLIN... | Wang, GY Yang, JH Zhang, ZG Lin, SH Lu, T Li, BF Jiang, L | 1996 | Chinese Chemical Letters1996，7，12： | 12 |
| 4 | The compression of IR spectra by using wavelet neural network显示文摘IR spectra play an important role in determining the structure of compounds qualitatively andquantitatively.In general a great number of data are required to exactly show the features ofthe compounds.Regarding various compounds,there are massive IR spectra.With the basicfeatures of IR spectra being reserved,it is important to compress IR spectra for improving thestorage,index and process of IR spectra.The wavelet neural network(WNN)is a newneural network model based on wavelet analysis.However,its introduction and applica-tion in chemistry have not been reported.In this note,WNN is applied to the compression ofthe IR spectra of polystyrene.The results show that the original spectra can be | Liu, W Li, JP Xiong, JH Pan, ZX Zhang, MS | 1997 | Chinese Science Bulletin1997，42，10： | 8 |
| 5 | Preparation of porous ceramic membrane from industrial product显示文摘BECAUSE ceramic membranes have excellent thermal stability,mechanic and structural stability,goodresistant stability to chemicals and microbes and high potential to be modified,on the one hand,ce-ramic membranes,as membrane separation materials,have an attractive prospect;on the other hand,it is possible to achieve the unification of reaction(especially for high temperature reaction)and sepa- | Li, AW Zhao, HB Gu, JH Ziong, GX | 1997 | Chinese Science Bulletin1997，42，9： | 5 |
| 6 | TRH microinjection into DVC enhances motility of rabbits gallbladder via vagus nerve显示文摘TRHmicroinjectionintoDVCenhancesmotilityofrabbitsgalbladderviavagusnerveLIUChuanYong,LIUJingZhang,ZHOUJianHua,WANGHanRu,... | Liu, CY Liu, JZ Zhou, JH Wang, HR Li, ZY Li, AJ Liu, KJ | 1998 | World Journal of Gastroenterology1998，4，2： | 4 |
| 7 | Diagnosis and management of cystic duct leakage after laparoscopic cholecystectomy, report of 3 cases显示文摘 | Li JH Liu HT | 2005 | 第二军医大学学报2005，26，10： | 3 |
| 8 | Pharmacokinetics of 9-nitro-20(S) -camptothecin in rats 显示文摘 | Zhong DF Li K Xu JH | 2003 | Acta Pharmacol Sin2003，24，3： | 2 |
| 9 | Intestinal flora translocation and overgrowth in upper gastrointestinal tract induced by hepatic failure显示文摘 | Yi JH Ni RY Luo DD Li SL | 1999 | World Gastroenterol1999，5，4： | 1 |
| 10 | Role of TGF-beta signaling in extracellular matrix production under high glucose conditions 显示文摘 | Li JH Huang XR Zhu HJ | 2003 | Kidney Int2003，63，6： | 1 |
| 11 | A nation-wide multicenter 10-year (1999-2008) retrospective clinical epidemiological study of female breast cancer in China显示文摘 | Li J Zhang BN Fan JH | 2011 | BMC Cancer2011，11，： | 1 |
| 12 | L1 cell adhesion molecule is a novel independent poor prognostic factor of extrahepatic cholangiocarcinoma显示文摘 | Li S Jo YS Lee JH | 2009 | Clin Cancer Res2009，15，23： | 1 |
| 13 | Active and passive smoking,and alcohol drinking and breast cancer risk in chinese women显示文摘 | Gao CM Ding JH Li SP | 2013 | A- sian Pacific J Cancer Prey2013，14，2： | 1 |
| 14 | Expression of αvβ6 integrin and collagen fibre in oral squamous cell carcinoma:association with clinical outcomes and prognostic implications显示文摘 | Li HX Zheng JH Fan HX | 2013 | J Oral Pathol Med2013，42，7： | 1 |
| 15 | Sesquiterpenoids and triterpenoids from Abies holophylla and their bioactivities 显示文摘 | Xia JH Zhang SD Li YL et 01 | 2012 | Phytochemistry2012，74，： | 1 |
| 16 | Modular pathway engineering of Bacillus subtilis for improved N-acetylglucosamine production显示文摘 | Liu YF Zhu YQ Li JH | 2014 | Metabolic Engineering2014，23，： | 1 |
| 17 | Are droughtsbecoming more frequent or severe in China based on thestandardized precipitation evapotranspiration Index: 1951 -2010?显示文摘 | Yu Meixiu Li Qiongfang Michael JH | 2014 | International Journal of Climatology2014，34，： | 1 |
| 18 | Smad7 inhibits fibrot- ic effect of TGF- Beta on renal tubular epithelial cells by blocking Smad2 aetivation显示文摘 | Li JH Zhu HJ Huang XR | 2002 | J Am $oc Nephrol2002，13，6： | 1 |
| 19 | Smad7 inhibits fibrotic effect of TGF-β on renal tubular epithelial cells by blocking Smad2 activation显示文摘 | Li JH Zhu HJ Huang XR | 2002 | J Am Soe Nephrol2002，13，6： | 1 |
| 20 | Optimization of solidstate medium for the production of inulinase by Kluyveromyces S120 using response surface methodology 显示文摘 | Chen X Wang JH Li DS | 2007 | Biochemical Engineering Journal2007，34，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员