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| 1 | Establishing the presence or absence of chronic kidney disease:Uses and limitations of formulas estimating the glomerular filtration rate显示文摘The development of formulas estimating glomerular filtration rate(eG FR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease(CKD),which is based on e GFR values and albuminuria.This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course. Disagreements between creatinine-based and cystatin-based e GFR values and between e GFR values and measured GFR have been reported in various cohorts. These disagreements are the consequence of variations in the rate of production and in factors, other than GFR, affecting the rate of removal of creatinine and cystatin C. The disagreements create limitations for all e GFR formulas developed so far. The main limitations are low sensitivity in detecting early CKD in several subjects, e.g., those with hyperfiltration, and poor prediction of the course of CKD. Research efforts in CKD are currently directed towards identification of biomarkers that are better indices of GFR than the current biomarkers and,particularly, biomarkers of early renal tissue injury. | Ahmed Alaini Deepak Malhotra Helbert Rondon-Berrios Christos P Argyropoulos Zeid J Khitan Dominic SC Raj Mark Rohrscheib Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Methodology2017，7，3： | 7 |
| 2 | Fluid balance concepts in medicine:Principles and practice显示文摘The regulation of body fluid balance is a key concern in health and disease and comprises three concepts. The first concept pertains to the relationship between total body water(TBW) and total effective solute and is expressed in terms of the tonicity of the body fluids. Disturbances in tonicity are the main factor responsible for changes in cell volume, which can critically affect brain cell function and survival. Solutes distributed almost exclusively in the extracellular compartment(mainly sodium salts) and in the intracellular compartment(mainly potassium salts) contribute to tonicity, while solutes distributed in TBW have no effect on tonicity. The second body fluid balance concept relates to the regulation and measurement of abnormalities of sodium salt balance and extracellular volume. Estimation of extracellular volume is more complex and error prone than measurement of TBW. A key function of extracellular volume, which is defined as the effective arterial blood volume(EABV), is to ensure adequate perfusion of cells and organs. Other factors, including cardiac output, total and regional capacity of both arteries and veins, Starling forces in the capillaries, and gravity also affect the EABV. Collectively, these factors interact closely with extracellular volume and some of them undergo substantial changes in certain acute and chronic severe illnesses. Their changes result not only in extracellular volume expansion, but in the need for a larger extracellular volume compared with that of healthy individuals. Assessing extracellular volume in severe illness is challenging because the estimates of this volume by commonly used methods are prone to large errors in many illnesses. In addition, the optimal extracellular volume may vary from illness to illness, is only partially based on volume measurements by traditional methods, and has not been determined for each illness. Further research is needed to determine optimal extracellular volume levels in several illnesses. For these reasons, extracellular volume in severe illness merits a separate third concept of body fluid balance. | Maria-Eleni Roumelioti Robert H Glew Zeid J Khitan Helbert Rondon-Berrios Christos P Argyropoulos Deepak Malhotra Dominic S Raj Emmanuel I Agaba Mark Rohrscheib Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2018 | World Journal of Nephrology2018，7，1： | 3 |
| 3 | Hyperthroidism and the heart显示文摘 | Christos P Antonios H Evagelos C | 2008 | Hellenic J Cardiol2008，49，2： | 1 |
| 4 | Hyperthyroidism and the heart显示文摘 | CHRISTOS P ANTONIOS H EVAGEIX)S C | 2008 | Hellenic J Cardiol2008，49，： | 1 |
| 5 | Convex combination of multiple statisti- cal models with application to VAD 显示文摘 | THEODOROS P CHRISTOS B FOTIOS T TAN Z H RAMJEE P | 2011 | IEEE Trans- actions on Audio Speech and Language Processing2011，19，8： | 1 |
| 6 | An alternative derivatization method for the analysis of amino acids in cerebrospinal fluid by gas chromatography-mass spectrometry 显示文摘 | de Paiva M J Menezes H C Christo P P | 2013 | J Chromatogr B2013，931，： | 1 |
| 7 | Latent semantic indexing: a probabilistie analysis显示文摘 | CHRISTOS H P PRABHAKAR R H TAMAKI S V | 2000 | Journal of Computer and System Sciences2000，61，2： | 1 |
| 8 | Latent semantic indexing : A probabilistic analysis 显示文摘 | Christos P H Prabhakar R Hisao T | 2000 | Journal of Computer and System Sciences2000，2，61： | 1 |
| 9 | Fatigue behavior of RC beams strengthened with GFRP sheets显示文摘 | Christos G P Michael F P KentA H | 2001 | Journal of Composites for Construction2001，5，4： | 1 |
| 10 | Strategies to Potentiate Antimicrobial Photoinactivation by Overcoming Resistant Phenotypes显示文摘 | Vera Domingo Mariano Adolfo Haynes Mark H Ball Anthony R Dai Tianhong Astrakas Christos Kelso Michael J Hamblin Michael R Tegos George P | 2012 | EN2012，，： | 1 |
| 11 | A BGP-based mechanism for lowest-cost routing 显示文摘 | Joan F Christos H P Rahul S | 2005 | Distributed Computing2005，18，1： | 1 |
| 12 | Latent Semantic Indexing:A Probabilistic Analysis显示文摘 | Christos P H Prabhakar R Hisao T | 2000 | Journal of Computer and System Sciences2000，2，61： | 1 |
| 13 | Fatigue behavior of RC beams strengthened with GFRP sheets 显示文摘 | Christos G P Michael F P Kent A H | 2001 | Journal of Composites for Construction2001，5，4： | 1 |
| 14 | An HNF-4u-miRNA Inflammatory Feedback Circuit regulates Hepatocellular Oncogenesis显示文摘 | Maria H Christos P Eleni A | 2011 | Cell2011，147，： | 1 |
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