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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Patients with Helicobacter pylori positive and negative duodenal ulcers have distinct clinical characteristics显示文摘AIM: To assess the clinical characteristics of Helicobacterpylori(H pylori) negative duodenal ulcer.METHODS: Patients with an endoscopic diagnosis of duodenal ulcer between 1996 and 2002 were included in the present study. Patients were considered to be negative for Hpylori, if both histological examination and rapid urease test of biopsy specimens were negative. A comparison was made between patients with H pyloripositive and negative duodenal ulcers.RESULTS: A total of 1 343 patients were studied. Their mean age was 54.7±0.5 years. There was a male preponderance (M:F = 2.5:1). Three hundred and ninetyeight patients (29.6%) did not have H pylori infection. The annual proportion of patients with H pylori negative duodenal ulcers increased progressively from 1996 to2002. On multivariate analysis, patients with H pylorinegative duodenal ulcer were more likely to be older, have concomitant medical problem, pre-existing malignancy, recent surgery, underlying sepsis, or taken non-steroidal anti-inflammatory drugs. In terms of clinical presentations, patients with H pylori negative duodenal ulcer were more likely to present with bleeding, multiple ulcers and larger ulcers.CONCLUSION: The proportion of patients with H pylori negative duodenal ulcers is on the rise because of a continued drop in incidence of H pylori positive duodenalulcers in recent years. Such patients have distinct clinical characteristics and it is important to ascertain the H pylori status before starting eradication therapy. | Kent-Man Chu Ka-Fai Kwok Simon Law Kam-Ho Wong | 2005 | World Journal of Gastroenterology2005，11，23： | 17 |
| 3 | Comparison of Hand-Sewn and Stapled Esophagogastric Anastomosis After Esophageal Resection for Cancer: A Prospective Randomized Controlled Trial显示文摘 | Simon Law Manson Fok Kent-Man Chu John Wong | 1997 | Annals of Surgery1997，，2： | 2 |
| 4 | Ca^2+-permeable acid-sensing ion channels and ischemic brain injury显示文摘 | Xiong ZG Chu XP Simon RP | 2006 | J Membr Biol2006，209，1： | 1 |
| 5 | Acid sensing ion channels novel therapeutic targets for ischemic brain injury显示文摘 | Xiong ZG Chu XP Simon RP | 2007 | Front Biosci2007，，12： | 1 |
| 6 | Acid sensing ion channels novel therapeutic targets for isehemic brain injury 显示文摘 | Xiong ZG Chu XP Simon RP | 2007 | Front Biosci2007，1，12： | 1 |
| 7 | The destruct ion of the lower urinary tractby ketamine abuse: a new syndrome? 显示文摘 | PEGGY SAU KWAN CH U WAI KIT MA SIMON CHU NWING WONG | 2008 | Brit J Urol Intern2008，102，： | 1 |
| 8 | Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls显示文摘 | Darren R. Brenner Paul Brennan Paolo Boffetta Christopher I. Amos Margaret R. Spitz Chu Chen Gary Goodman Joachim Heinrich Heike Bickeb?ller Albert Rosenberger Angela Risch Thomas Muley John R. McLaughlin Simone Benhamou Christine Bouchardy Juan Pablo Lew | 2013 | Human Genetics2013，，： | 1 |
| 9 | Ca^2+-permeable acidsensing ion channels and isehemic brain injury 显示文摘 | Xiong ZG Chu XP Simon RP | 2006 | J Membrane Biol2006，209，1： | 1 |
| 10 | Acid-sensing ion channels-novel therapeutic targets for ischemic brain injury 显示文摘 | Xiong ZG Chu XP Simon RP | 2007 | Frontiers Biosci2007，12，： | 1 |
| 11 | Ca^2+-permeable Acid-sensing Ion Channels and Ischemic Brain Injury显示文摘 | XIONG ZG CHU XP SIMON RP | 2006 | J Membr Biol(S0022-2631)2006，209，： | 1 |
| 12 | The destruction of the lower urinary tract by Ket- amine absue: a new syndrome 显示文摘 | Peggy Sau - Kwan Chu Wai - Kit Ma Simon Chun - Wing Wang | 2008 | BJU International2008，102，11： | 1 |
| 13 | Acid sensing ion channels-novel therapeutic targets for ischemic brain injury显示文摘 | Xiong ZG Chu XP Simon RP | 2007 | Front Biosci2007，1，12： | 1 |
| 14 | Acid sensing ion channels-no- vel therapeutic targets for ischemic brain injury 显示文摘 | XIONG ZG CHU XP SIMON RP | 2007 | Frontiers Biosci2007，12，： | 1 |
| 15 | 显示文摘 | Chrysler G M Chu R C Simons R E | 1995 | IEEE Transactions on Components Packaging and Manufacturing Technology (Part A)1995，18，3： | 1 |
| 16 | Scanning electron microscopy and electron microprobe studies of bitter pit in apples 显示文摘 | Simons R O Y K Chu M E L C | 1980 | Acta Hort (ISHS)1980，92，： | 1 |
| 17 | Ca2+ -permeable acid-sensing ion chan- nels and ischemic brain injury显示文摘 | Xiong ZG Chu XP Simon RP | 2006 | J Membr Biol2006，209，1： | 1 |
| 18 | Acid sensing ion channels-novel therapeutic targets for ischemic brain injury显示文摘 | Xiong ZG Chu XP Simon RP | 2007 | Front B iosci2007，12，： | 1 |
| 19 | Immunopathogenic behaviors of canine transmissible venereal tumor in dogs following an immunotherapy using dendritic/tumor cell hybrid显示文摘 | Chien-Chun Pai Tzong-Fu Kuo Simon J.T. Mao Tien-Fu Chuang Chen-Si Lin Rea-Min Chu | 2010 | Veterinary Immunology and Immunopathology2010，，2： | 1 |
| 20 | Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer显示文摘 | Suet Yi Leung Siu Tsan Yuen Kent-Man Chu Jonathan A. Mathy Rui Li Annie S.Y. Chan Simon Law John Wong Xin Chen Samuel So | 2004 | Gastroenterology2004，，2： | 1 |
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