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| 1 | Patients with Helicobacter pylori positive and negative duodenal ulcers have distinct clinical characteristics显示文摘AIM: To assess the clinical characteristics of Helicobacterpylori(H pylori) negative duodenal ulcer.METHODS: Patients with an endoscopic diagnosis of duodenal ulcer between 1996 and 2002 were included in the present study. Patients were considered to be negative for Hpylori, if both histological examination and rapid urease test of biopsy specimens were negative. A comparison was made between patients with H pyloripositive and negative duodenal ulcers.RESULTS: A total of 1 343 patients were studied. Their mean age was 54.7±0.5 years. There was a male preponderance (M:F = 2.5:1). Three hundred and ninetyeight patients (29.6%) did not have H pylori infection. The annual proportion of patients with H pylori negative duodenal ulcers increased progressively from 1996 to2002. On multivariate analysis, patients with H pylorinegative duodenal ulcer were more likely to be older, have concomitant medical problem, pre-existing malignancy, recent surgery, underlying sepsis, or taken non-steroidal anti-inflammatory drugs. In terms of clinical presentations, patients with H pylori negative duodenal ulcer were more likely to present with bleeding, multiple ulcers and larger ulcers.CONCLUSION: The proportion of patients with H pylori negative duodenal ulcers is on the rise because of a continued drop in incidence of H pylori positive duodenalulcers in recent years. Such patients have distinct clinical characteristics and it is important to ascertain the H pylori status before starting eradication therapy. | Kent-Man Chu Ka-Fai Kwok Simon Law Kam-Ho Wong | 2005 | World Journal of Gastroenterology2005，11，23： | 17 |
| 2 | Inactivation of Mitochondrial Complex Ⅰ Induces the Expression of a Twin Cysteine Protein that Targets and Affects Cytosolic, Chloroplastidic and Mitochondrial Function显示文摘At12Cys-1 (At5g64400 ) 和 At12Cys-2 (At5g09570 ) 是二密切相关的 isogenes 编码小、成双的半胱氨酸蛋白质,典型地在线粒体定位了。At12Cys-2 抄本与破坏 mitochondrial 蛋白质,而是 At12Cys 的增加在许多异种被导致蛋白质仅仅与减少的 mitochondrial 在异种被检测复杂我丰富。在缺乏 mitochondrial 建筑群的异种的 At12Cys 蛋白质感应我被位于线粒体,叶绿体,和 cytosol 的 At12Cys 蛋白质伴随。生物化学的分析揭示了那甚至单个的基因删除,即, At12cys-1 或 At12cys-2,在 mitochondrial 和叶绿体功能上有效果。然而,仅仅加倍异种,即, At12cys-1 : At12cys-2,影响许多蛋白质和 mRNA 抄本编码翻译延伸因素以及 rRNA 丰富。蓝本国的页证明 At12Cys 与 mitochondrial supercomplex 共同移居我 + III。同样, At12cys-1 和 At12cys-2 基因的删除,然而并非单个基因删除,导致提高的忍耐到干旱和轻应力和增加的抗氧化剂能力。正式就职和在在建筑群的减小之上的 At12Cys 的多重本地化我丰富提供机制明确地表明 mitochondrial 机能障碍到 cytosol 然后在以外到在房间的另外的细胞器。 | Yan Wang Wenhui Lyu Oliver Berkowitz Jordan D. Radomiljac Simon R. Law Monika W. Murcha Chris Carrie Pedro F. Teixeira Beata Kmiec Owen Duncan Olivier Van Aken Reena Narsai Elzbieta Glaser Shaobai Huang Ute Roessner A. Harvey Millar James Whelan | 2016 | Molecular Plant2016，9，5： | 5 |
| 3 | Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal squamous cell carcinoma显示文摘AIM: To identify the downstream regulated genes of GAEC1 oncogene in esophageal squamous cell carcinoma and their clinicopathological significance. METHODS: The anti-proliferative effect of knocking down the expression of GAEC1 oncogene was stud-ied by using the RNA interference (RNAi) approach through transfecting the GAEC1 -overexpressed esophageal carcinoma cell line KYSE150 with the pSilencer vector cloned with a GAEC1 -targeted sequence, followed by MTS cell proliferation assay and cell cycle analysis using flow cytometry. RNA was then extracted from the parental, pSilencer-GAEC1 -targeted sequence transfected and pSilencer negative control vector transfected KYSE150 cells for further analysis of different patterns in gene expression. Genes differentially expressed with suppressed GAEC1 expression were then determined using Human Genome U133 Plus 2.0 cDNA microarray analysis by comparing with the parental cells and normalized with the pSilencer negative control vector transfected cells. The most prominently regulated genes were then studied by immunohistochemical staining using tissue microarrays to determine their clinicopathological correlations in esophageal squamous cell carcinoma by statistical analyses. RESULTS: The RNAi approach of knocking down gene expression showed the effective suppression of GAEC1 expression in esophageal squamous cell carcinoma cell line KYSE150 that resulted in the inhibition of cell proliferation and increase of apoptotic population. cDNA microarray analysis for identifying differentially expressed genes detected the greatest levels of downregulation of calpain 10 (CAPN10 ) and upregulation of trinucleotide repeat containing 6C (TNRC6C ) transcripts when GAEC1 expression was suppressed. At the tissue level, the high level expression of calpain 10 protein was significantly associated with longer patient survival (month) of esophageal squamous cell carcinoma compared to the patients with low level of calpain 10 expression (37.73 ± 16.33 vs 12.62 ± 12.44, P = 0.032). No significant correction was observed among the TNRC6C protein expression level and the clinocopathologcial features of esophageal squamous cell carcinoma. CONCLUSION: GAEC1 regulates the expression of CAPN10 and TNRC6C downstream. Calpain 10 expression is a potential prognostic marker in patients with esophageal squamous cell carcinoma. | Dessy Chan Miriam Yuen-Tung Tsoi Christina Di Liu SauHing Chan Simon Ying-Kit Law Kwok-Wah Chan Yuen-Piu Chan Vinod Gopalan Alfred King-Yin Lam Johnny Cheuk-On Tang | 2013 | World Journal of Gastroenterology2013，19，18： | 2 |
| 4 | Comparison of Hand-Sewn and Stapled Esophagogastric Anastomosis After Esophageal Resection for Cancer: A Prospective Randomized Controlled Trial显示文摘 | Simon Law Manson Fok Kent-Man Chu John Wong | 1997 | Annals of Surgery1997，，2： | 2 |
| 5 | Optimum Lymphadenectomy for Esophageal Cancer显示文摘 | Nabil P. Rizk Hemant Ishwaran Thomas W. Rice Long-Qi Chen Paul H. Schipper Kenneth A. Kesler Simon Law Toni E. M. R. Lerut Carolyn E. Reed Jarmo A. Salo Walter J. Scott Wayne L. Hofstetter Thomas J. Watson Mark S. Allen Valerie W. Rusch Eugene H. Blacksto | 2010 | Annals of Surgery2010，，1： | 2 |
| 6 | Predicting Systemic Disease in Patients With Esophageal Cancer After Esophagectomy: A Multinational Study on the Significance of the Number of Involved Lymph Nodes显示文摘 | Christian G. Peyre Jeffrey A. Hagen Steven R. DeMeester Jan J. B. Van Lanschot Arnulf H?lscher Simon Law Alberto Ruol Ermanno Ancona S Michael Griffin Nasser K. Altorki Thomas W. Rice John Wong Toni Lerut Tom R. DeMeester | 2008 | Annals of Surgery2008，，6： | 1 |
| 7 | Barrett’s esophagus: cancer and molecular biology显示文摘 | Michael K. Gibson Arashinder S. Dhaliwal Nicholas J. Clemons Wayne A. Phillips Katerina Dvorak Daniel Tong Simon Law E. Daniel Pirchi Jari R?s?nen Mark J. Krasna Kaushal Parikh Kausilia K. Krishnadath Yu Chen Leonard Griffiths Benjamin J. Colleypriest J. | 2013 | Ann NY Acad Sci2013，，1： | 1 |
| 8 | Subtotal hepatectomy: a porcine model for the study of liver regeneration显示文摘 | Fiona G Court Peter E Laws Charles P Morrison Benjamin D Teague Matthew S Metcalfe Simon A Wemyss-Holden Ashley R Dennison Guy J Maddern | 2004 | Journal of Surgical Research2004，，1： | 1 |
| 9 | Clinical Cystoid Macular Edema After Cataract Surgery in Glaucoma Patients显示文摘 | Simon K. Law Eujin Kim Fei Yu Joseph Caprioli | 2010 | Journal of Glaucoma2010，，2： | 1 |
| 10 | Optic Disk and Nerve Fiber Layer Imaging to Detect Glaucoma显示文摘 | Federico Badalà Kouros Nouri-Mahdavi Duna A. Raoof Narakorn Leeprechanon Simon K. Law Joseph Caprioli | 2007 | American Journal of Ophthalmology2007，，5： | 1 |
| 11 | Barrett’s esophagus: cancer and molecular biology显示文摘 | Michael K. Gibson Arashinder S. Dhaliwal Nicholas J. Clemons Wayne A. Phillips Katerina Dvorak Daniel Tong Simon Law E. Daniel Pirchi Jari R?s?nen Mark J. Krasna Kaushal Parikh Kausilia K. Krishnadath Yu Chen Leonard Griffiths Benjamin J. Colleypriest J. | 2013 | Ann. N.Y. Acad. Sci2013，，1： | 1 |
| 12 | Characterization of Mechanical Vibration Damping by Piezoelectric Materials显示文摘 | Law H H Rossiter P L Simon G P | 1996 | Journal of Sound and Vibration1996，197，4： | 1 |
| 13 | Prospective Evaluation of Acupuncture as Treatment for Glaucoma显示文摘 | Simon K. Law Starrie Lowe Samuel M. Law JoAnn A. Giaconi Anne L. Coleman Joseph Caprioli | 2015 | American Journal of Ophthalmology2015，，2： | 1 |
| 14 | Laparoscopic surgery induced interleukin-6 levels in serum and gut mucosa: implications of peritoneum integrity and gas factors显示文摘 | John M. Luk Peter H. Tung Kwong-Fai Wong Kwong-Leung Chan Simon Law John Wong | 2009 | Surgical Endoscopy2009，，2： | 1 |
| 15 | Long-term Outcomes of Ahmed Glaucoma Valve Implantation in Refractory Glaucomas显示文摘 | Carlos Souza Duc H. Tran Jane Loman Simon K. Law Anne L. Coleman Joseph Caprioli | 2007 | American Journal of Ophthalmology2007，，6： | 1 |
| 16 | Establishment, characterization, karyotyping, and comparative genomic hybridization analysis of HKESC-2 and HKESC-3显示文摘 | Ying Chuan Hu King Y. Lam Simon Y. Law Thomas S.K. Wan Edmond S.K. Ma Yok Lam Kwong Li C. Chan John Wong Gopesh Srivastava | 2002 | Cancer Genetics and Cytogenetics2002，，2： | 1 |
| 17 | Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer显示文摘 | Suet Yi Leung Siu Tsan Yuen Kent-Man Chu Jonathan A. Mathy Rui Li Annie S.Y. Chan Simon Law John Wong Xin Chen Samuel So | 2004 | Gastroenterology2004，，2： | 1 |
| 18 | Use of flow cytometry in the analysis of stage Ⅲ squamous cell carcinoma of the oesophagus and its association with MIB-1 显示文摘 | KY Lam Lily Ma Simon Y K Law | 1996 | J Clin Pathol1996，49，12： | 1 |
| 19 | Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression:a prognostic marker of human esophageal squamous cell carcinomas显示文摘 | Yi Ren Brian Cao Simon Law | 2005 | Clinical Cancer Research2005，11，： | 1 |
| 20 | The Current Management of Esophageal Cancer显示文摘 | Simon Law John Wong | 2007 | Advances in Surgery2007，，： | 1 |
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