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| 1 | Relationship of MTHFR gene polymorphisms with renal and cardiac disease显示文摘AIM: To investigate the effects of different methylenetetrahydrofolate reductase(MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are controversial.METHODS: We challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. The present article is a reappraisal of these concepts, investigating within a larger population, and including a subgroup of dialysis patients, if the two most common MTHFR polymorphisms, C677 T and A1298 C, as homozygous, heterozygous or with a compound heterozygous state, show different association with chronic renal failure requiring hemodialysis. MTHFR polymorphism could be a favorable evolutionary factor, i.e., a protective factor for many ominous conditions, like cancer and renal failure. A similar finding was reported in fatty liver disease in which it is suggested that MTHFR polymorphisms could have maintained and maintain their persistence by an heterozygosis advantage mechanism. We studied a total of 630 Italian Caucasian subject aged 54.60 ± 16.35 years, addressing to the increased hazard of hemodialysis, if any, according to the studied MTHFR genetic polymorphisms. RESULTS: A favorable association with normal renal function of MTHFR polymorphisms, and notably of MTHFR C677 T is present independently of the negative effects of left ventricular hypertrophy, increased IntraRenal arterial Resistance and hyperparathyroidism. CONCLUSION: MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism. | Francesca M Trovato Daniela Catalano Angela Ragusa G Fabio Martines Clara Pirri Maria Antonietta Buccheri Concetta Di Nora Guglielmo M Trovato | 2015 | World Journal of Nephrology2015，4，1： | 10 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Development of self-assembled bacterial cellulose-starch nanocomposites 显示文摘 | Cristian J Grande Fernando G Torres Clara M Gomez | 2009 | Materials Science and Engineering C2009，29，4： | 1 |
| 4 | Identification of relevant micropollutants in Austrian municipal wastewater and their behaviour during wastewater treatment显示文摘 | CLARA M WINDHOFER G WEILGONY P | 2012 | Chemosphere2012，87，11： | 1 |
| 5 | Development of self-assembled bacterial cellulose-starch nanocomposites显示文摘 | Cristian J Grande Femando G Torres Clara M Gomez | 2009 | Materials Science and Engineering C2009，29，4： | 1 |
| 6 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 7 | Occurrence of phthalates in surface runoff,untreated and treated wastewater and fate during wastewater treatment显示文摘 | Clara M Windhofer G Hartl W | 2010 | Chemosphere2010，78，9： | 1 |
| 8 | Laboratory studies for light- oil air injection projects: potential application in Handil Field显示文摘 | Clara C Durandeau M Quenault G | 2000 | SPE Reservoir Evaluation & Engineering2000，3，3： | 1 |
| 9 | Curemonitoring of catalysed cyanate ester resins显示文摘 | Isabel Harismendy Clara M Gómez Marcos Del Río | 2000 | Polymer Internation-al2000，49，7： | 1 |
| 10 | Cure monitoring of catalysed cyanate ester resins显示文摘 | ISABEL H CLARA M G MARCOS D R | 2000 | Polymer International2000，49，7： | 1 |
| 11 | Occurrence of polycyclic musks in wastewater and receiving water bodies and fate during wastewater treatment 显示文摘 | CLARA M GANS O WINDHOFER G | 2011 | Chemosphere2011，82，8： | 1 |
| 12 | ADV36 adipogenic adenovirus in human liver disease显示文摘obesity and liver steatosis are usually described as related diseases.obesity is regarded as exclusive consequence of an imbalance between food intake and physical exercise,modulated by endocrine and genetic factors.Non-alcoholic fatty liver disease(NAFLD),is a condition whose natural history is related to,but not completely explained by over-nutrition,obesity and insulin resistance.There is evidence that environmental infections,and notably adipogenic adenoviruses(ADV)infections in humans,are associated not only with obesity,which is sufficiently established,but also with allied conditions,such as fatty liver.In order to elucidate the role,if any,of previous ADV36 infection in humans,we investigated association of ADV36-ADV37 seropositivity with obesity and fatty liver in humans.Moreover,the possibility that lifestyle-nutritional intervention in patients with NAFLD and different ADV36 seropositive status,achieves different clinical outcomes on ultrasound bright liver imaging,insulin resistance and obesity was challenged.ADV36 seropositive patientshave a more consistent decrease in insulin resistance,fatty liver severity and body weight in comparison with ADV36 seronegative patients,indicating a greater responsiveness to nutritional intervention.These effects were not dependent on a greater pre-interventional body weight and older age.These results imply that no obvious disadvantage-and,seemingly,that some benefit-is linked to ADV36 seropositivity,at least in NAFLD.ADV36 previous infection can boost weight loss and recovery of insulin sensitivity under interventional treatment. | Francesca M Trovato Daniela Catalano Adriana Garozzo G Fabio Martines Clara Pirri Guglielmo M Trovato | 2014 | World Journal of Gastroenterology2014，20，40： | 1 |
| 13 | Occurrence of phthalates in surface runoff, untreated and treated wastewater and fate duringwastewater treatment显示文摘 | Clara M Windhofer G Hartl W | 2010 | Chemosphere2010，78，9： | 1 |
| 14 | 17B-Estradiol inhibits inflammatory gene expression by controlling NF-kB intracellular lecalization显示文摘 | Clara M Adriana M | 2005 | Mol Cell Biol2005，25，8： | 1 |
| 15 | Cure monitoring of catalysed cyanate ester resins 显示文摘 | Isabel H Clara M G Marcos D R | 2000 | Polymer International2000，49，7： | 1 |
| 16 | Cure monitoring of catalysed cyanate ester resins 显示文摘 | ISABEL H CLARA M G MARCOS D R | 2000 | Polymer International2000，49，7： | 1 |
| 17 | Association between nutritional status and severity of dengue infection in children in E1 Salvador显示文摘 | Maron G M Clara A W Diddle J W | 2010 | Am J Trop Med Hyg2010，82，2： | 1 |
| 18 | The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis显示文摘 | SANDRA M N CLARA L SUDAGAR S G GURDYAL S B COLIN W W | 2002 | Journal of Ethnopharmacology2002，79，1： | 1 |
| 19 | Occurrence of polycyclic musks in wastewater and receiving water bodies and fateduring wastewater treatment显示文摘 | CLARA M GANS O WINDHOFER G | 2011 | Chemosphere2011，82，8： | 1 |
| 20 | Occurrence ofphthalates in surface runoff, untreated and treated wastewater and fate during wastewater treatmcnt显示文摘 | Clara M Windhofer G Hartl W | 2010 | Chemosphere2010，78，9： | 1 |
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