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| 1 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 2 | Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia显示文摘 | Wang HK Fung HC Hsu WC Wu YR Lin JC Ro LS Chang KH Hwu FJ Hsu Y Huang SY Lee-Chen GJ Chen CM | 2006 | 中国生物学文摘2006，20，8： | 8 |
| 3 | Self-organization of Gold Nanoparticles Protected by 9-(5-Thiopentyl)-carbazole显示文摘Through the reduction of [AuCl4]- by aqueous sodium borohydride in the presence of 9-(5-thiopentyl)-carbazole, the gold nanoparticles has been prepared and characterized. | Wang, S Li, YL Du, CM Shi, ZQ Xiao, SX Fang, HJ Zhu, DB | 2001 | Chinese Chemical Letters2001，12，12： | 4 |
| 4 | Association of telomere length with authentic pluripotency of ES/iPS cells显示文摘Telomerase 和 telomeres 为干细胞的不定的复制是重要的。最近,体的房间的 telomeres 被发现是 reprogrammed 在导致的 pluripotent 干细胞(iPSCs ) 伸长。然而,在在胚胎的干细胞(转换字符) 或 iPSCs 的 vivo 的发展 pluripotency 的 telomeres 的角色直接没被探讨。我们证明有长 telomeres 的转换字符展出真发展 pluripotency,由完全的转换字符小狗以及 germline 能干的怪物的产生证实了在啮齿类动物可得到的最紧的测试。有短 telomeres 的转换字符显示出减少的 teratoma 形成和怪物生产,并且没能产生完全的转换字符小狗。Telomere 长度高度被相关(r > 0.8 ) 与转换字符的发展 pluripotency。短 telomeres 减少 proliferative 率或转换字符的能力,改变与 telomere epigenetics 有关的基因的表示,为 embryogenesis 重要的下面调整基因并且破坏细菌房间区别。而且,有更长的 telomeres 的 iPSCs 与短 telomeres 比那些与更高的效率产生怪物。我们功能的 telomeres 为 ESCs/iPSCs 的发展 pluripotency 是必要的并且建议那 telomere 长度可以提供一个珍贵标记评估干细胞 pluripotency 的数据表演,特别地当紧测试不是可行的时。 | Junjiu Huang Fang Wang Maja Okuka Na Liu Guangzhen Ji Xiaoying Ye Bingfeng Zuo Minshu Li Ping Liang William W Ge John CM Tsibris David L Keefe Lin Liu | 2011 | Cell Research2011，21，5： | 3 |
| 5 | P38MAPK kinase mediates cytoskeletal remodeling in pulmonary microvascular endothelial cells upon ICAM-1 ligation显示文摘 | Wang Q Doerschuk CM | 2001 | Immunol2001，166，： | 2 |
| 6 | Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: role of the 55 kDa TNF receptor (TNFRI) 显示文摘 | Crisostomo PR Wang M Herring CM | 2007 | J Mol Cell Cardiol2007，42，1： | 1 |
| 7 | Correlation of quantitative assay of hepatitis B surface antigen and HBV DNA levels in asymptomatic hepatitis B virus carriers显示文摘 | Chen CH lee CM Wang JH | 2004 | Eur J Gastroenterol Hepatol2004，16，： | 1 |
| 8 | Amino acid availability regulates p70 S6 kinase and multiple translation factors显示文摘 | Wang X Campbell LE Miller CM | 1998 | Biochem J1998，334，1： | 1 |
| 9 | The role of eamitine in the male reproductive system显示文摘 | Ng CM Blackman MR Wang C | 2004 | Ann N Y Acad Sci2004，1033，： | 1 |
| 10 | Dexame-thasone has a central antiemetic mechanism in decerebrated cats 显示文摘 | Ho CM Ho ST Wang JJ | 2004 | Anesth Analg2004，99，3： | 1 |
| 11 | Determ inants of hum- an pap illom avirus Ioad am ong woman with his tological cervrcal intraepithelial neop lasia 3: dom inant impact of surrounding 1ow-grade lesions显示文摘 | Sherman ME Wang SS Wheeler CM et aI | 2003 | Cancer Epidem lob fore arkers P rev2003，12，10： | 1 |
| 12 | Thyroid dysfunction in patients with chronic hepatitis C receiving a combined therapy of interferon and fibavirin:incidence, associated factors and prognosis显示文摘 | Kee KM Lee CM Wang JH | 2006 | J Gastroenterol Hepatol2006，21，12： | 1 |
| 13 | The analysis of pat-terns and risk {actors of newly developed vertebral com- pression fractures after percutaneous vertebroplasty显示文摘 | Yoo CM Park KB H wang SH | 2012 | J Korean Neurosurg Soc2012，52，4： | 1 |
| 14 | Laparoscopic management of gastrointestinal stromal tumors显示文摘 | Nguyen SQ Divino CM Wang JL | 2006 | Surg Endosc2006，20，5： | 1 |
| 15 | The p38MAPK mitogen-activated protein kinase mediates cytoskeletal remodeling in pulmonary microvascular endothelial cells upon intracellular adhesion molecule-1 ligation显示文摘 | Wang Q Doerschuk CM | 2001 | J Immunol2001，166，11： | 1 |
| 16 | Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson′s disease显示文摘 | Wu YR Wang CK Chen CM | 2004 | Hum Genet2004，114，： | 1 |
| 17 | The role of carnitine in the male reproductive system显示文摘 | Ng CM Blackman MR Wang C | 2004 | Ann N Y Acad Sci2004，1033，1： | 1 |
| 18 | Are current defimtiolts of sarcopenia applicable for older Chinese adults? 显示文摘 | Wen X Wang M Jiang CM etal | 2011 | J Nutr Hea- lthAging2011，15，10： | 1 |
| 19 | Nebulized hypertonic saline treatment reduces both rate and duration of hospitalization for acute bronchiolitis in infants: an updated meta- analysis 显示文摘 | Chen YJ Lee WL Wang CM | 2014 | Pediatr Neonatol2014，55，6： | 1 |
| 20 | New multifunctional melatonin- derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease 显示文摘 | Luo XT Wang CM Liu Y | 2015 | Eur J Med Chem2015，103，： | 1 |
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