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| 1 | Types,Characteristics and Significances of Migrating Pathways of Gas-bearing Fluids in the Shenhu Area,Northern Continental Slope of the South China Sea显示文摘The first marine gas hydrate expedition in China has been conducted by Guangzhou Marine Geological Survey in the Shenhu Area, northern continental slope of the South China Sea. Previous study has analyzed the P-T conditions, geophysical anomalies and saturation calculations of these gas hydrates, but has not documented in detail the migration of gas-bearing fluids in the study area. Based on the interpretations of 2D/3D seismic data, this work identified two types of migration pathways for gas-bearing fluids in the Shenhu area, i.e., vertical and lateral pathways. The vertical pathways(largescale faults, gas chimneys and mud diapirs) presented as steep seismic reflection anomalies, which could be traced downward to the Eocene source rocks and may penetrate into the Late Miocene strata. The deeper gases/fluids might be allowed migrating into the shallower strata through these vertical conduits. However, the distributions showed distinct differences between these pathways. Large-scale faults developed only in the north and northeast of the Shenhu area, while in the drilling area gas chimneys were the sole vertical migration pathways. Since the Pliocene, normal faults, detachment faults and favorable sediments have constituted the lateral pathways in the Shenhu gas hydrate drilling area. Although these lateral pathways were connected with gas chimneys, they exerted different effects on hydrate formation and accumulation. Gas-bearing fluids migrated upward along gas chimneys might further migrate laterally because of the normal faults, thereby enlarging the range of the chimneys. Linking gas chimneys with the seafloor, the detachment faults might act as conduits for escaping gases/fluids. Re-deposited sediments developed at the early stage of the Quaternary were located within the gas hydrate stability zone, so hydrates would be enriched in these favorable sediments. Compared with the migration pathways(large-scale faults and mud diapirs) in the LW3-1 deep-sea oil/gas field, the migration efficiency of the vertical pathways(composed of gas chimneys) in the gas hydrate drilling area might be relatively low. Description and qualitative discrimination of migration pathways in the Shenhu gas hydrate drilling area are helpful to further understand the relationship between good-quality deep source rocks and shallow, mainly biogenicallyproduced, hydrates. As the main source rocks of the Baiyun sag, lacustrine mudstones in the Wenchang and Enping Formations may provide thermogenic methane. Gas chimneys with relatively low migration efficiency created the vertical pathways. Caused by the Dongsha tectonic movement, the release of overpressured fluids might reduce the vertical migration rates of the thermogenic methane. The thick bathyal/abyssal fine-grained sediments since the Late Miocene provided migration media with low permeability. These preconditions may cause carbon isotopic fractionation ofthermogenic methane during long-distance vertical migrations. Therefore, although geochemical analyses indicate that the methane forming gas hydrate in the Shenhu area was mainly produced biogenically, or was mixed methane primarily of microbial origin, thermogenic methane still contribute significantly. | SU Ming SHA Zhibin ZHANG Cuimei WANG Hongbin WU Nengyou YANG Rui LIANG Jinqiang QIAO Shaohua CONG Xiaorong LIU Jie | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 16 |
| 2 | The Relationship between Tectonic Subsidence and BSR of Upper Neogene in the Deep-Water Area of the Northern Continental Slope, South China Sea显示文摘BSR (Bottom Simulating Reflector) occurs widely in the strata since the late Miocene in the deep-water area of the northern continental slope of South China Sea (SCS). It is an important seismic reference mark which identifies the gas hydrate and its distribution influenced by the tectonic movements. Single-point basin modeling was conducted using 473 points in the study area. To discuss the relationships between the tectonic subsidence and BSR, the volume and rate of tectonic subsidence in each geological time have been simulated. The results show that there are three tectonic accelerate subsidence processes in the study area since the late Miocene, especially since 1.8Ma the tectonic subsidence accelerates more apparently. Since the Late Miocene to Pleistocene, the rate of tectonic subsidence in deep-water underwent a transformation from weak to strong. The ratio of tectonic subsidence to the total subsidence was relatively high (65-70%). Through the superposition of the BSR developed areas and the contours of tectonic subsidence in this area, it was discovered that more than 80% of BSR tend to be distributed at the slope break or depression-uplift structural transfer zone and the average tectonic subsidence rate ranges from 70 m/Ma to 125 m/Ma. | YU Xinghe WANG Jianzhong LI Shengli FANG Jingnan JIANG Longyan CONG Xiaorong LIANG Jinqiang SHA Zhibin | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 6 |
| 3 | Re-examination on The Contribution of Deep Thermogenic Gas to Shallow Hydrate in The Shenhu Area,Northern Continental Slope of South China Sea显示文摘1 Introduction*In April-June of 2007,the Expedition GMGS-1 was completed successfully in the Shenhu Area of the South China Sea.Gas hydrate was detected at three(Sites SH2,SH3 and SH7)of the five sites that were cored.The Shenhu gas hydrate drilling area is located in the central | CONG Xiaorong QIAO Shaohua WU Nengyou YANG Rui SU Pibo | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 1 |
| 4 | Recommendations for the diagnosis and treatment of paroxysmal kinesigemc dyskinesia: an expert consensus in China显示文摘Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes.Paroxysmal kinesigenic dyskinesia(PKD)is the most common type of paroxysmal dyskinesia and can be divided into primary and secondary types based on the etiology.Clinically,PKD is characterized by recurrent and transient attacks of involuntary movements precipitated by a sudden voluntary action.The major cause of primary PKD is genetic abnormalities,and the inheritance pattern of PKD is mainly autosomal-dominant with incomplete penetrance.The proline-rich transmembrane protein 2(PRRT2)was the first identified causative gene of PKD,accounting for the majority of PKD cases worldwide.An increasing number of studies has revealed the clinical and genetic characteristics,as well as the underlying mechanisms of PKD.By seeking the views of domestic experts,we propose an expert consensus regarding the diagnosis and treatment of PKD to help establish standardized clinical evaluation and therapies for PKD.In this consensus,we review the clinical manifestations,etiology,clinical diagnostic criteria and therapeutic recommendations for PKD,and results of genetic analyses in PKD patients performed in domestic hospitals. | Li Cao Xiaojun Huang Ning Wang Zhiying Wu Cheng Zhang Weihong Gu Shuyan Cong Jianhua Ma Ling Wei Yanchun Deng Qi Fang Qi Niu Jin Wang Zhaoxia Wang You Yin Jinyong Tian Shufen Tian Hongyan Bi Hong Jiang Xiaorong Liu Yang Lu Meizhen Sun Jianjun Wu Erhe Xu Tao Chen Tao Chen Xu Chen Wei Li Shujian Li Qinghua Li Xiaonan Song Ying Tang Ping Yang Yun Yang Min Zhang Xiong Zhang Yuhu Zhang Ruxu Zhang Yi Ouyang Jintai Yu Quanzhong Hu Qing Ke Yuanrong Yao Zhe Zhao Xiuhe Zhao Guohua Zhao Furu Liang Nan Cheng Jianhong Han Rong Peng Shengdi Chen Beisha Tang | 2021 | Translational Neurodegeneration2021，10，1： | 1 |
| 5 | Efficacy and safety of subsequent radiotherapy in patients with advanced-stage hepatocellular carcinoma treated with immune checkpoint inhibitors显示文摘Background:The development of immunotherapy resistance is associated with a poor prognosis in patients diagnosed with hepatocellular carcinoma(HCC)who are undergoing treatment with immune checkpoint inhibitors(ICI).This study aimed to evaluate the efficacy and safety of subsequent radiotherapy(RT)for patients with advanced-stage HCC who had lesion enlargement or new lesions(NLs)during ICI therapy.Methods:This retrospective observational study enrolled 36 patients with advanced-stage HCC who underwent subsequent RT for lesion enlargement or NLs during ICI therapy from two centers.The primary endpoints were progression-free survival(PFS)and overall survival(OS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),1-and 2-year local control(LC)rates,in-field PFS(IFPFS),out-field PFS(OFPFS),and safety.Results:The median follow-up time was 15.3 months.The median PFS was 7.4 months[95%confidence interval(CI):3.1-11.7 months],and the median OS was 18.8 months(95%CI:17.1-20.5 months).ORR and DCR were 38.9%and 72.2%,respectively.In addition,the median IFPFS was 17.8 months(95%CI:11.5-24.2 months),median OFPFS was 7.9 months(95%CI:3.4-12.5 months),and estimated 1-and 2-year LC rates were 67.1%and 31.9%,respectively.The most common treatment-related adverse events(all grades)were diarrhea(33.3%),rash(30.6%),and malaise(27.8%);a total of 14(38.9%)patients developed grade 3-4 AEs.Conclusions:Subsequent RT showed reliable antitumor effects and an acceptable safety profile in patients with advanced-stage HCC who had unsatisfactory response to ICI therapy;therefore,it could serve as an optional salvage strategy. | Cong Ning Jun Jia Xinmu Zhang Jing Sun Yunchao Wang Jingnan Xue Longhao Zhang Xiaorong Hou Xiaobo Yang Xinting Sang Xuezhang Duan Haitao Zhao | 2023 | Hepatobiliary Surgery and Nutrition2023，12，6： | 0 |
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