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| 1 | Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies显示文摘The antibody repertoire of Bos taurus is characterized by a subset of variable heavy(VH)chain regions with ultralong third complementarity determining regions(CDR3)which,compared to other species,can provide a potent response to challenging antigens like HIV env.These unusual CDR3 can range to over seventy highly diverse amino acids in length and form uniqueβ-ribbon‘stalk’and disulfide bonded‘knob’structures,far from the typical antigen binding site.The genetic components and processes for forming these unusual cattle antibody VH CDR3 are not well understood.Here we analyze sequences of Bos taurus antibody VH domains and find that the subset with ultralong CDR3 exclusively uses a single variable gene,IGHV1-7(VHBUL)rearranged to the longest diversity gene,IGHD8-2.An eight nucleotide duplication at the 3′end of IGHV1-7 encodes a longer V-region producing an extended Fβ-strand that contributes to the stalk in a rearranged CDR3.A low amino acid variability was observed in CDR1 and CDR2,suggesting that antigen binding for this subset most likely only depends on the CDR3.Importantly a novel,potentially AID mediated,deletional diversification mechanism of the B.taurus VH ultralong CDR3 knob was discovered,in which interior codons of the IGHD8-2 region are removed while maintaining integral structural components of the knob and descending strand of the stalk in place.These deletions serve to further diversify cysteine positions,and thus disulfide bonded loops.Hence,both germline and somatic genetic factors and processes appear to be involved in diversification of this structurally unusual cattle VH ultralong CDR3 repertoire. | Thaddeus C Deiss Melissa Vadnais Feng Wang Patricia L Chen Ali Torkamani Waithaka Mwangi Marie-Paule Lefranc Michael F Criscitiello Vaughn V Smider | 2019 | Cellular & Molecular Immunology2019，16，1： | 4 |
| 2 | Synergies between vaccination and dietary arginine and glutamine supplementation improve the immune response of channel catfish against Edwardsiella ictaluri显示文摘 | Pohlenz C Buentello A Criscitiello M F | 2012 | Fish & Shellfish Immunology2012，33，： | 1 |
| 3 | Prognostic value of tumor-infihrating lymphocytes on residual disease after primary chemotherapy for triple-negative breast cancer: a retrospective mul- ticenter study 显示文摘 | Dieci MV Criscitiello C Goubar A | 2014 | Ann Oncol2014，25，61： | 1 |
| 4 | Molecular pathways:human leukocyte antigen G(HLA-G)显示文摘 | Curigliano G Criscitiello C Gelao L | 2013 | Clin Cancer Res2013，19，20： | 1 |
| 5 | Prognostic value of tumor - infiltrating lymphocytcs on residual disease after primary chemotherapy for triple - negative breast cancer: a retrospective multicenter study 显示文摘 | Dieci MV Criscitiello C Goubar A | 2014 | Ann Oncol2014，25，3： | 1 |
| 6 | HER2 signaling pathway and trastuzumab cardiotoxicity显示文摘 | Criscitiello C Curigliano G | 2013 | Future Oncol2013，9，2： | 1 |
| 7 | Monitoring tumor-derived cell-free DNA in patients with solid tumors: Clinical perspectives and research opportunities 显示文摘 | Esposito A Bardelli A Criscitiello C | 2013 | Cancer Treat Rev2013，11，5： | 1 |
| 8 | Understanding the biology of triple-negative breast cancer显示文摘 | Criscitiello C Azim HA Jr Schouten PC | 2012 | Ann Oncol2012，23，6： | 1 |
| 9 | Targeted thera pies in breast cancer: are heart and vessels also being targeted? 显示文摘 | Criscitiello C Metzger-Filho O Saini KS | 2012 | Breast Cancer Res2012，14，3： | 1 |
| 10 | High Ki-67 score is indicative of greater benefit from adjuvant chemotherapy when added to endocrine therapyin Luminal B HER2 negative and node-positive breast cancer显示文摘 | CRISCITIELLO C DISALVATORE D DE LAURENTIIS M | 2014 | Breast2014，23，1： | 1 |
| 11 | Crosstalk between bone niche and immune system: Osteoimmunology signaling as a potential target for cancer treatment 显示文摘 | Criscitiello C Viale G Gelao L | 2015 | Cancer Treat Rev2015，41，2： | 1 |
| 12 | Prognostic value of tumor-infiltrating lymphocytes on residual disease after primary chemotherapy for triple-negative breast cancer: a retrospective multicenter study显示文摘 | Dieci MV Criscitiello C Goubar A | 2014 | Ann Oncol2014，25，3： | 1 |
| 13 | Gene modules and re-sponse to neoadjuvant chemotherapy in breast cancersubtypes: a pooled analysis 显示文摘 | Ignatiadis M Singhal S K Desmedt C Haibe-Kains B Criscitiello C Andre F | 2012 | J Clin Oncol2012，30，： | 1 |
| 14 | Prognostic value of tumor infiltrating lymphocytes on residual disease after pri mary chemotherapy for triple-negative breast cancer:a retro spectivemulticenter study显示文摘 | Dieci M V Criscitiello C Goubar A | 2014 | Ann Oncol2014，25，3： | 1 |
| 15 | Investigational platelet-derived growth factor receptor kinase inhibitors in breast cancertherapy 显示文摘 | Criscitiello C Gelao L Viale G | 2014 | Expert Opin Investig Drugs2014，23，5： | 1 |
| 16 | Dendritic cell-based vaccines: clinical applications in breast cancer 显示文摘 | Gelao L Criscitiello C Esposito A | 2014 | Immunotherapy2014，6，3： | 1 |
| 17 | Allelic polymorphism of TCRα chain constant domain genes in the bicolor damselfish显示文摘 | Criscitiello M F Kamper S M McKinney E C | 2004 | Dev Comp Immunol2004，28，78： | 1 |
| 18 | Understanding the biology of triple-negative breast cancer显示文摘 | Criscitiello C Azim HA Schouten PC | 2012 | Ann Oncol2012，236，： | 1 |
| 19 | R2 signaling pathway and trastuzumab cardiotoxicity 显示文摘 | Criscitiello C Curigliano G | 2013 | Future Oncol2013，9，2： | 1 |
| 20 | HER2 signaling pathway and trastuzumab cardiotoxicity显示文摘 | Criscitiello C Curigliano G | 2013 | Future Oncol2013，9，2： | 1 |
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