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2篇 您的检索式:作者名="CUI Yanxing"
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1Early changes to the extracellular space in the hippocampus under simulated microgravity conditions显示文摘The smooth transportation of substances through the brain extracellular space(ECS)is crucial to maintaining brain function;however,the way this occurs under simulated microgravity remains unclear.In this study,tracer-based magnetic resonance imaging(MRI)and DECS-mapping techniques were used to image the drainage of brain interstitial fluid(ISF)from the ECS of the hippocampus in a tail-suspended hindlimb-unloading rat model at day 3(HU-3)and 7(HU-7).The results indicated that drainage of the ISF was accelerated in the HU-3 group but slowed markedly in the HU-7 group.The tortuosity of the ECS decreased in the HU-3 group but increased in the HU-7 group,while the volume fraction of the ECS increased in both groups.The diffusion rate within the ECS increased in the HU-3 group and decreased in the HU-7 group.The alterations to ISF drainage and diffusion in the ECS were recoverable in the HU-3 group,but neither parameter was restored in the HU-7 group.Our findings suggest that early changes to the hippocampal ECS and ISF drainage under simulated microgravity can be detected by tracer-based MRI,providing a new perspective for studying microgravity-induced nano-scale structure abnormities and developing neuroprotective approaches involving the brain ECS.Yajuan Gao Hongbin Han Jichen Du Qingyuan He Yanxing Jia Junhao Yan Hui Dai Bin Cui Jing Yang Xunbin Wei Liu Yang Rui Wang Ren Long Qiushi Ren Xing Yang Jiabin Lu 2022Science China(Life Sciences)2022,65,3:2
2Improved Numerical Computing Method for the 3D Tidally Induced Lagrangian Residual Current and Its Application in a Model Bay with a Longitudinal Topography显示文摘An improved method for computing the three-dimensional(3 D)first-order Lagrangian residual velocity(uL)is estab-lished.The method computes tidal body force using the harmonic constants of the zeroth-order tidal current.Compared with using the tidal-averaging method to compute the tidal body force,the proposed method filters out the clutter other than the single-frequency tidal input from the open boundary and obtains uL that is more consistent with the analytic solution.Based on the new method,uL is calculated for a wide bay with a longitudinal topography.The strength and pattern of uL are mostly determined by the parts of the tidal body force related to the vertical mixing of the Stokes’drift and the Coriolis effect,with a minor contribution from the advection effect.The geometrical shape of the bay can influence uL through the topographic gradient.The magnitude of uL increases with the increases in tidal energy input and vertical eddy viscosity and decreases in terms of the bottom friction coefficient.CUI Yanxing JIANG Wensheng ZHANG Jinghua 2019Journal of Ocean University of China2019,18,6:0
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