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| 1 | Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation显示文摘AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.METHODS: Constipation was diagnosed by Rome Ⅱ criteria.Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.RESULTS: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology. | Annie OO Chan Cecilia Cheng Wai Mo Hui Wayne HC Hu Nina YH Wong KF Lam Wai Man Wong Kam Chuen Lai Shiu Kum Lam Benjamin CY Wong | 2005 | World Journal of Gastroenterology2005，11，34： | 92 |
| 2 | Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non-Small-Cell Lung Cancer(摘要)显示文摘 | Hu, ZB Chen, X Zhao, Y Tian, T Jin, GF Shu, YQ Chen, YJ Xu, L Zen, K Zhang, CY Shen, HB | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 141 |
| 3 | RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform显示文摘我们以前报导了人的 ACAT1 基因通过从染色体抄录的二不连续的 RNA 处理的 interchromosomal 生产妄想的 mRNA 1 和 7。妄想的 mRNA 把 AUG1397-1399 和 GGC1274-1276 用作翻译开始 codons 分别地,与在人的房间是确实地在场的后者生产正常 50-kDa ACAT1 和新奇酶地活跃的 56-kDa isoform,包括人的导出单核白血球的巨噬细胞。在这个工作,我们报导位于 GGC1274-1276 codon 的附近的 RNA 第二等的结构为 56-kDa isoform 的生产被要求。三预言的茎环(nt 1255-1268, 1286-1342 和 1355-1384 ) 的效果被 transfecting 表示 plasmids 个别地测试进包含的房间野类型,删除或变异的茎环序列连接了到一个部分 ACAT1 8 月开的读物框架(ORF ) 或到另外的基因的 ORF。表示模式被西方的污点分析监视。我们发现从染色体 7 的在上游的 stem-loop1255-1268 和从染色体 1 的下游的 stem-loop1286-1342 为 56-kDa isoform 的生产被需要,而从染色体 1 的最后 stem-loop1355-1384 是非必需的。用有一个稳定的发卡的 monocistronic 和 bicistronic 向量的实验的结果证明从 GGC1274-1276 codon 的那翻译开始被一个内部核糖体入口地点(怒火) 调停。进一步的实验表明从 GGC1274-1276 codon 的那翻译开始要求在上游的组成 AU 的 RNA 第二等的结构和下游地 GC 富有的结构。这个机械学的工作为人的 ACAT1 抄本的妄想的性质的生物意义提供进一步的支持。 | Jia Chen Xiao-Nan Zhao Li Yang Guang-Jing Hu Ming Lu Ying Xiong Xin-Ying Yang Catherine CY Chang Bao-Liang Song Ta-Yuan Chang Bo-Liang Li | 2008 | Cell Research2008，18，9： | 5 |
| 4 | Production of ACAT1 56-kDa isoform in human cells via trans-splicing involving the ampicillin resistance gene显示文摘拼接 Trans,包含劈开并且二个分开的抄本加入的一个过程,能在优核质扩展 transcriptome 和 proteome。拼接 trans 产生的妄想的 RNA 逐渐地在文学被描述。在自然环境和人的肠的抗菌素抵抗基因的普遍存在为公共健康正在成为重要挑战。某些抗菌素抵抗基因,例如氨比西林抵抗基因(安培 r ), 经常在 recombinant plasmids 被使用。直到现在,拼接 trans 包含 recombinant 导出 plasmid 的外长的抄本和内长的细胞的 RNA 没被报导。Acyl-CoA:cholesterol acyltransferase (ACAT1 ) 1 是涉及细胞的胆固醇动态平衡的关键酶。4.3-kb 人 ACAT1 妄想的 mRNA 能与不同酶的活动生产 50-kDa 和 56-kDa isoforms。这里,我们证明人的 ACAT1 56-kDa isoform 从通过安培 r ( asAmp )现在在普通安培 r -plasmids 和 4.3-kb 内长的 ACAT1 妄想的 mRNA ,它大概通过 interchromosomal 拼接trans 的一个优先的事件被处理。惊人地,与一个在上游的重新结合的神秘倡导者一起包含 asAmp 的 DNA 碎片和相应外长的 asAmp 抄本在人的房间被检测了。我们的调查结果使人的 ACAT1 56-kDa isoform 生产的机制清楚些,揭示一个外长内长的拼接 trans 系统,在 recombinant,导出 plasmid 的外长的抄本在人的房间与内长的细胞的 RNA 被连接,并且建议外长的 DNA 可能影响在 DNA 和 RNA 层次的人的基因表示。 | Guang-Jing Hu Jia Chen Xiao-Nan Zhao Jia-JiaXu Dong-Qing Guo Ming Lu Ming Zhu Ying Xiong Qin Li Catherine CY Chang Bao-Liang Song Ta-Yuan Chang Bo-Liang Li | 2013 | Cell Research2013，23，8： | 4 |
| 5 | Nasopharyngeal carcinoma with dermatomyositis:a clinical analysis of 30 cases显示文摘 | Hu WH Pau CY Zhuang CH | 1986 | Chin J Oncol1986，8，： | 1 |
| 6 | Physical activity of moderate intensity and risk of type 2 diabetes: a systematic review 显示文摘 | Jeon CY Lokken RP Hu FB | 2007 | Diabetes Care2007，30，3： | 1 |
| 7 | The relationship between coronary artery disease and abnormal glucose regulation in China:The China Heart Survey显示文摘 | Hu DY Pan CY Yu JM | 2006 | Eur Heart J2006，27，： | 1 |
| 8 | Association between apolipoprotein Egene polymorphism and depression 显示文摘 | Fang F Lu SS Hu CY | 2015 | J Clin Neurosci2015，22，8： | 1 |
| 9 | Expression of a 64 KD adipocyte- specific plasma membrane protein in genetically lean but not obese porcine adipocytes显示文摘 | Hu CY | 1990 | J Cell Biochem1990，44，3： | 1 |
| 10 | Mammalian Mstl and Mst2 kinases play essential roles in organ size control and tumor suppression显示文摘 | Song H Mak KK Topol L Yun K Hu J Garrett L Chen Y Park O Chang J Simpson RM Wang CY Gao B Jiang J Yang Y | 2010 | Proc Natl Acad Sci U S A2010，107，4： | 1 |
| 11 | Treating Chemical Mechanical Polishing (CMP) Wastewater by Electro -coagulation -flotation Process with Surfactant显示文摘 | Hu CY | 2005 | Journal of Hazardous Materials2005，120，： | 1 |
| 12 | Various forms of homocysteine and oxidative status in the plasma of ischemic-stroke patients as compared to healthy controls显示文摘 | Yang TH Chang CY Hu ML | 2004 | Clin Biochem2004，37，： | 1 |
| 13 | Protection against oxidized low-density lipoprotein-induced vascular endothelial cell death by integrin linked kinase显示文摘 | Zhang X Hu K Li CY | 2001 | Circulation2001，104，： | 1 |
| 14 | Separation of four flavonoids from Rhodiola rosea by on-line combination of sample preparation and counter-current chromatography显示文摘 | Ma CY Hu LM Fu QY | 2013 | Journal of Chromatography A2013，1306，1： | 1 |
| 15 | Synthesis, characterization and dual photochroic properties of azo-substituted polythiophene derivatives 显示文摘 | Zhao X Hu X Yue CY | 2002 | Thin Solid Films2002，417，： | 1 |
| 16 | MicroRNA-328 may influence myopia development by mediating the PAX6 gene显示文摘 | Chen KC Hsi E Hu CY | 2012 | Invest Ophthalmol Vis Sci2012，53，6： | 1 |
| 17 | The Epidemiology of alcohol consumption and misuse among Chinese college students 显示文摘 | Ji CY Hu PJ Song Y | 2012 | Alcohol Alcoholism2012，47，4： | 1 |
| 18 | Valproate reduces tau phosphorylation via cyclin - dependent kinase 5 and glycogen synthase kinase 3 signaling pathways 显示文摘 | Hu JP Xie JW Wang CY | 2011 | Brain Res Bull2011，85，34： | 1 |
| 19 | A novel risk-adjusted nomogram for rectal cancer surgery outcomes显示文摘 | RUSSELL MC YOU YN HU CY | 2013 | JAMA Surg2013，148，8： | 1 |
| 20 | Risk factors for clopidogrel resistance in patients with ischemic cerebral infarction and the correlation with gene rs1045642 polymorphism显示文摘 | Su JF Hu XH Li CY | 2015 | Exp Ther Med2015，9，1： | 1 |
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