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| 1 | 通过监测乙型肝炎患者耐药突变株比例的变化推测cccDNA的快速更新周期显示文摘【据Hepatology 2021年1月报道】题:通过监测乙型肝炎患者耐药突变株比例的变化推测ccc DNA的快速更新周期(作者Huang Q等)来自南方医科大学南方医院的孙剑教授课题组利用两项已结束的随机对照临床研究样本,以拉米夫定耐药(LAMR)突变位点—rt M204I/V作为标记,以rt M204I/V耐药株相对于野毒株的比例变化,推测ccc DNA池的更新周期。 | 陆星宇 周彬孙 HUANG Q ZHOU B CAI D | 2021 | 临床肝胆病杂志2021，37，4： | 16 |
| 2 | Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms显示文摘Cadmium(Cd)is a nonessential heavy metal and a prevalent environmental toxin that has been shown to induce significant cardiomyocyte apoptosis in neonatal murine engineered cardiac tissues(ECTs).In contrast,zinc(Zn)is a potent metallothionein(MT)inducer,which plays an important role in protection against Cd toxicity.In this study,we investigated the protective effects of Zn against Cd toxicity in ECTs and explore the underlying mechanisms.ECTs were constructed from neonatal ventricular cells of wild-type(WT)mice and mice with global MT gene deletion(MT-KO).In WT-ECTs,Cd(5−20μM)caused a dose-dependent toxicity that was detected within 8 h evidenced by suppressed beating,apoptosis,and LDH release;Zn(50−200μM)dose-dependently induced MT expression in ECTs without causing ECT toxicity;co-treatment of ECT with Zn(50µM)prevented Cd-induced toxicity.In MT-KO ECTs,Cd toxicity was enhanced;but unexpectedly,cotreatment with Zn provided partial protection against Cd toxicity.Furthermore,Cd,but not Zn,significantly activated Nrf2 and its downstream targets,including HO-1;inhibition of HO-1 by a specific HO-1 inhibitor,ZnPP(10µM),significantly increased Cd-induced toxicity,but did not inhibit Zn protection against Cd injury,suggesting that Nrf2-mediated HO-1 activation was not required for Zn protective effect.Finally,the ability of Zn to reduce Cd uptake provided an additional MT-independent mechanism for reducing Cd toxicity.Thus,Zn exerts protective effects against Cd toxicity for murine ECTs that are partially MT-mediated.Further studies are required to translate thesefindings towards clinical trials. | Hai-tao Yu Juan Zhen Jian-xiang Xu Lu Cai Ji-yan Leng Hong-lei Ji Bradley B Keller | 2020 | Acta Pharmacologica Sinica2020，41，5： | 3 |
| 3 | The strain amplitude-controlled cyclic fatigue behavior of Al_2O_3 fiber reinforced Al-Si alloy composite at elevated temperatures | Guohua Zhang a,c,Bingchao Li b,Jianxin Zhang b,Wei Cai a a School of Materials Science and Engineering,Harbin Institute of Technology,Harbin 150001,China b School of Materials Science and Engineering,Shandong University,Jinan 250061,China c Shandong Binzhou Bohai Piston Co.,Ltd,Binzhou 256602,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 2 |
| 4 | Unique cyclic deformation behavior of a heavily alloyed Al-Si piston alloy at different temperatures | Guohua Zhang a,c,Bingchao Li b,Jianxin Zhang b,Zengjian Feng c,Zuoshan Wei c,Wei Cai a a School of Materials Science and Engineering,Harbin Institute of Technology,92 West Dazhi Street,P.O.Box 405,Harbin 150001,China b School of Materials Science and Engineering,Shandong University,17923 Jingshi Road,Jinan 250061,China c Shandong Binzhou Bohai Piston Co.,Ltd,569 Bohai Ershiyi Road,Binzhou 256602,China | 2012 | Progress in Natural Science:Materials International2012，22，5： | 2 |
| 5 | Laparoscopically assisted sigmoid colon vaginoplasty in women Mayer-Rokitansky-Kuster- Hauser syndrome: feasibility and short-term results 显示文摘 | Cai B Zhang JR Xi XW | 2007 | BJOG2007，114，： | 1 |
| 6 | Down-regulation of epidermal growth factor receptor signaling pathway by binging of GRP78/Bip to the receptor under glucose starved stress conditions 显示文摘 | Cai B Tomida A Mikami K | 1998 | Cell Physiol1998，177，2： | 1 |
| 7 | Blue light-induced apoptosis of A2Econtaining RPE: involvement of caspase-3 and protection by Bcl-2 显示文摘 | Sparrow JR Cai B | 2001 | Invest Ophthalmol Vis Sci2001，42，6： | 1 |
| 8 | Modulation of myostatin expression during modified muscle use显示文摘 | Wehling M Cai B Tidhall J G | 2000 | Faseb J2000，14，： | 1 |
| 9 | Comparison of MRS and DWI in the diagnosis of prostate cancer based on sextant analysis显示文摘 | Li B Cai W Lv D | 2013 | J Magn Reson Imaging2013，37，： | 1 |
| 10 | Research progress of keloid scar treatment 显示文摘 | Li H B Cai J L | 2004 | Chinese Medical Journal2004，4，2： | 1 |
| 11 | Image Restoration: Total Variation; Wavelet Frames; and Beyond 显示文摘 | Cai J F Dong B Osher S | 2012 | Journal of American Mathematical Society2012，25，4： | 1 |
| 12 | Genome - wide analy- sis of the AP2/ERF gene family in Populus trichocarpa 显示文摘 | Zhuang J Cai B Peng RH | 2008 | Biochemical and Biophysical Research Communica- tions2008，371，3： | 1 |
| 13 | Vascular endothelial growth factor C promotes survival of retinal vascular endothelial cells via vascular endothelial growth factor receptor-2显示文摘 | Zhao B Smith G Cai J | | 0，，4： | 1 |
| 14 | Autom ated Generation of Person- al Data Reports from Relational Databases显示文摘 | Fakas G J Cawley B Cai Zhi | 2011 | Journal of Infor- mation &Knowledge Management (JIKM)2011，10，2： | 1 |
| 15 | A major QTL controlling seed dormancy and pre-harvest sprouting resistance on chromo- some 4A in a Chinese wheat landrace显示文摘 | Chen C X Cai S B Bai G H | 2008 | Molecular Breed- ing2008，21，3： | 1 |
| 16 | The realization of low stress and nonangular distortion by doublesided double arc welding 显示文摘 | Zhang H J Zhang G J Cai C B | 2009 | Journal of Manufacturing Science and Engineering2009，131，4： | 1 |
| 17 | Overvolted breakdown and recovery of short nitrogen spark gaps显示文摘 | Cai X J Zou X B Wang X X | 2010 | Laser and Particle Beams2010，28，3： | 1 |
| 18 | A numerical three-dimensional eontact model for rough, multilayered elastic/plastic solid surfaces 显示文摘 | S Cai B Bhushan | 2005 | Wear2005，259，14： | 1 |
| 19 | Complex dynamics of a diffusive epidemic model with strong Allee effect显示文摘 | Cai Y L Liu W B Wang Y B | 2013 | Nonlinear Analysis:Real World Applications2013，14，： | 1 |
| 20 | Complex dynamics of a diffusive epidemic model with strong Allee effect显示文摘 | CAI Y L LIU W B WANG Y B | 2013 | Nonlinear Analysis:Real World Applications2013，14，4： | 1 |
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