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| 1 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 2 | 利用洋底地震资料估算进入马里亚纳俯冲带的水通量显示文摘俯冲带水迁移是地表水进入地球深部的主要方式。但是,通过板块俯冲到底能够带入深部地幔多少水受到多种因素影响,包括俯冲带板片年龄、俯冲带几何性质、俯冲带热结构、板块汇聚速率等。目前关于俯;中带的水循环仍知之甚少。最近,华盛顿大学地球与行星科学系的Cai C博士等人收集和分析了马里亚纳海沟中心周围宽频洋底瑞利面波地震数据,估算了通过板块俯冲输入地球深部的水通量。他们的研究结果表明:板块俯冲带入深部地幔的水通量是以前估算的4.3倍,而且远大于目前对地幔输出水通量的估计。由于大量的长期净水流入地球深处与地质记录中的海平面稳定性不一致;同时也没有迹象表明马里亚纳俯冲带的板块弯曲区在形态和断裂强度与其它古俯冲带的对应区域对比有很大的不同。 | Cai C Wiens D A Shen W Eimer M 张宝华 | 2018 | 矿物岩石地球化学通报2018，37，6： | 13 |
| 3 | Novel DNA vaccine based on hepatitis B virus core gene induces specific immune responses in Balb/c mice显示文摘AIM: To investigate the immunogenicity of a novel DNA vaccine,pSW3891/HBc, based on HBV core gene in Balb/c mice.METHODS: A novel DNA vaccine, pSW3891/HBc, encoding HBV core gene was constructed using a vector plasmid pSW3891. Balb/c mice were immunized with either pSW3891/HBc or empty vector DNA via gene gun. IgG anti-HBc responses in mouse sera were demonstrated by ELISA. Specific cytotoxicity of cytotoxic T lymphocytes (CTLs) of mice was quantitatively measured by lactate dehydrogenase release assay.RESULTS: HBcAg was expressed effectively in 293T cell line transiently transfected with pSW3891/HBc. Strong IgG anti-HBc responses were elicited in mice immunized with pSW3891/HBc. The end-point titers of anti-HBc reached the highest 1:97 200, 4 wk after the third immunization. The specific CTL killing with the highest specific lysis reached 73.25% at effector:target ratio of 20:1 in mice that received pSW3891/HBc DNA vaccine.CONCLUSION: pSW3891/HBc vaccination elicits specific anti-HBc response and induces HBc-specific CTL response in immunized Balb/c mice. | Yi-Ping Xing Zu-Hu Huang Shi-Xia Wang Jie Cai Jun Li Te-Hui W Chou Shan Lu | 2005 | World Journal of Gastroenterology2005，11，29： | 7 |
| 4 | The New Synthesis of Azo Urea from Substituted Semicarbazide显示文摘Using N-bromosuccinimide and pridine as the 0xidation s}-stem to dehydrogenale anly substituted semicarbazide to form azo compounds is described for the firs1 time in this paper Nine azo conlpounds have been prepared in excellent lield under mild condition This method onle needs simple instrument and short reaction | Xiao Yang WANG Yu Lu WANG Jian Ping LI Cai ’Lan W’ANG Hong WANG (Department of Chemistry ,Henan Normal University Xinxiang 453002 ) | 1997 | Chinese Chemical Letters1997，8，6： | 5 |
| 5 | Investigation on reversible pump turbine flow structures and associated pressure field characteristics under different guide vane openings显示文摘The use of reversible pump turbines(RPT) within pumped storage power plants goes with prolonged periods of off-design operating conditions, which leads to the onset of operating mode-dependent instabilities. In order to decrease the gravity of RPT flow instabilities and associated damages or even completely eliminate them, a deep understanding of its onset and development mechanism is needed. In line with this, the present study seeks to numerically investigate the onset and development mechanism of RPT unsteady flow structures as well as the evolutional characteristics of associated pressure pulsations throughout the RPT complete flow passage, under off-design conditions for three GVOs namely 17, 21, and 25 mm. The study results showed that low torque operating conditions and associated vaneless space back flow structures were the trigger of flow unsteadiness onset within the RPT vaneless space, the instabilities which grew to cause the S-shape characteristics appearance. Moreover, the runner flow unsteadiness was found to decrease with the GVO increase. On the other hand, the GVO increase worsened the pressure pulsation levels within RPT flow zones, where pressure pulsations within the vaneless space and flow zones in its vicinities were found to be the most sensitive to GVO changes. | BINAMA Maxime SU WenTao CAI WeiHua LI FengChen WEI XianZhu MUHIRWA Alex GONG RuZhi WEKESA David W | 2019 | Science China(Technological Sciences)2019，62，11： | 5 |
| 6 | Effects of Heat Treatment on the Transformation Temperature and the Microstructure of Ni-Ti-Nb Shape Memory Alloy显示文摘The effects of heat treatment on the phase transformation temperature and the microstructure of Ni-Ti-Nb alloy have been investigated by means of R-T method, TEM and EPMA. With the increase of annealing temperature, cooling rate and ageing temperature, the Ms temperature increases. TEM observations show no new precipitated phase was found in the B2 parent phase after heat treatment, but EPMA shows the content of Ni (or Ni/Ti ratio) in the B2 matrix changed. The main reason for the change of transformation temperature lies in the change of the matrix composition (or Ni/Ti ratio) with the variation of heat treatment procedure. | Zheng, YF Cai, W Wang, YQ Luo, YC Zhao, LC | 1998 | Journal of Materials Science & Technology1998，14，1： | 4 |
| 7 | Advanced proportional-integralderivative tuning for integrating and unstable processes with gain and phase margin specifications 显示文摘 | Wang Y G Cai W J | 2002 | Ind Eng Chem Res2002，41，12： | 2 |
| 8 | Study on mechanism of ceramics grinding显示文摘 | Kitajima K Cai G Q Kumagai N Tanaka Y Zheng H W | 1992 | Annals of the CIRP1992，41，1： | 2 |
| 9 | 土壤微生物生态学研究方法进展显示文摘 | Cai Y F Liao Z W | | 土壤与环境0，，： | 2 |
| 10 | Antiprotozal activities of Centipeda minima显示文摘 | Yu H W WRIGHT C W CAI Y | 1994 | Phytoherapy Research1994，8，： | 1 |
| 11 | Enhanced Plasticity in a Zr- Based Bulk Metallic Glass Containing Nanocrystalline Precipitates 显示文摘 | Dong W Zhang H Cai J | 2006 | Journal of Alloys and Compounds2006，425，： | 1 |
| 12 | Photocatalytic degradation of phenol in aqueous nitrogen-doped TiO2 suspensions with various light sources 显示文摘 | Wang Z P Cai W M Hong X T | 2005 | Appl Catal B Environ2005，57，： | 1 |
| 13 | Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal ceils 显示文摘 | Cai J Li W Su H | 2010 | J Biol Chem2010，285，11： | 1 |
| 14 | The role of the Indone- sian Throughflow on ENSO dynamics in a coupled 'climate model 显示文摘 | Santoso A Cai W England M H | 2011 | Journal of Climate2011，24，： | 1 |
| 15 | S100A12 provokes mast cell activation: a potential amplification pathway in asthma and innate immunity显示文摘 | Yang Z Yan W X Cai H | 2007 | J Allergy Clin Immunol2007，119，1： | 1 |
| 16 | Robust identification of first-order plus dead- time model from step response 显示文摘 | Bi Q Cai W J | 1999 | Control Engineering Practice1999，6，7： | 1 |
| 17 | (1 mod 3)-cycles 显示文摘 | Cai Xiaotao Shreve W | | preprint0，，： | 1 |
| 18 | Hydrogen peroxide mediates defence responses induced by chitosans of different molecular weights in rice显示文摘 | Lin W L Hu X Y Zhang W Q John R W Cai W M | 2005 | Journal of Plant Physiology2005，162，8： | 1 |
| 19 | Changes in weed community diversity of maize crops due to long-term fertilization显示文摘 | YIN L C CAI Z C ZHONG W H | 2006 | Crop Protection2006，25，： | 1 |
| 20 | A fem that hyperaccumulates arsenic显示文摘 | Ma L Q Komar K M Tu C Zhang W H Cai Y Kennelley E D | 2001 | Nature2001，409，： | 1 |
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