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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Detection of contaminants in cell cultures, sera and trypsin显示文摘 | Tatiana Flávia Pinheiro de Oliveira Ant?nio Augusto Fonseca Marcelo Fernandes Camargos Anapolino Macedo de Oliveira Ana Cláudia Pinto Cottorello Antonizete dos Reis Souza Iassudara Garcia de Almeida Marcos Bryan Heinemann | 2013 | Biologicals2013，，6： | 2 |
| 3 | National study of emergen- cy department visits for acute exacerbation of chronic obstructive pulmonary disease, 1993 - 2005 显示文摘 | Tsai CL Sobrino JA Camargo CA Jr | 2008 | Acad Emerg Med2008，15，12： | 1 |
| 4 | Acute exacerbations of COPD:delay in presentation and the risk of hospitalization显示文摘 | Chandra D Tsai CL Camargo CA Jr | 2009 | COPD2009，6，2： | 1 |
| 5 | lntcrleukin-6 prntects liwr a- gainst warm ischemia/reperfusion injury and promotes hepatocytc pro- liferation in the rdent显示文摘 | Camargo CA Madden JF ( ao W cl al | 1997 | tlepatology1997，26，6： | 1 |
| 6 | National study of emergency department visits for acute exacerbation of chronic obstructive pulmonary disease, 1993-2005 显示文摘 | Tsai CL Sobrino JA Camargo CA Jr | 2008 | Acad Emerg Med2008，15，12： | 1 |
| 7 | Predictive factors for height gain in idiopathic central precocious puberty treated with GnRH analogues 显示文摘 | Benetti-Pinto CL Camargo LB Magna LA | 2008 | Rev Bras Ginecol Obstet2008，30，12： | 1 |
| 8 | Acute exacerbations of COPD:delay in presentation and the risk of hospitalization显示文摘 | Chandra D Tsai CL Camargo CA | | 0，，02： | 1 |
| 9 | Acute exacerbations of COPD:delay in presentation and the risk of hospitalization显示文摘 | Chandra D Tsai CL Camargo CA Jr | 2009 | COPD2009，6，2： | 1 |
| 10 | Bone marrow stromal cells and resorbable collagen guidance tubes enhance sciatic nerve regeneration in mice显示文摘 | Pereira LR Camargo DE Moura CL | 2006 | Exp Neurol2006，198，2： | 1 |
| 11 | A prospective,open,comparative study of 5%potassium hydroxide solution versuscryotherapy in the treatment of genital warts in men显示文摘 | Camargo CL Belda Junior W Fagundes LJ | 2014 | An Bras Dermatol2014，89，2： | 1 |
| 12 | Acute exacerbations of COPD:delay in presentation and the risk of hospitalization显示文摘 | Chandra D Tsai CL Camargo CA Jr | 2009 | COPD2009，6，2： | 1 |
| 13 | Men and women living in marital violence: socioeconomic aspects 显示文摘 | Gomes NP Diniz NM Camargo CL el at | 2012 | Rev Gaucha Enferm2012，33，2： | 1 |
| 14 | National study of emer- gency department visits for acute exacerbation of chronic obstruc- tive pulmonary disease, 1993 2005 显示文摘 | Tsai CL Sobrino JA Camargo CA Jr | 2008 | Acad Emerg Med2008，15，12： | 1 |
| 15 | National study of emergen- cy department visits for acute exacerbation of chronic obstructive pulmonary disease, 1993 - 2005 显示文摘 | Tsai CL Sobrino JA Camargo CA Jr | 2008 | Acad Emerg Med2008，15，12： | 1 |
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