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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Eccentric training as a new approach for rotator cuff tendinopathy: Review and perspectives显示文摘Excessive mechanical loading is considered the major cause of rotator cuff tendinopathy. Although tendon problems are very common, they are not always easy to treat. Eccentric training has been proposed as an effective conservative treatment for the Achilles and patellar tendinopathies, but less evidence exists about its effectiveness for the rotator cuff tendinopathy. The mechanotransduction process associated with an adequate dose of mechanical load might explain the beneficial results of applying the eccentric training to the tendons. An adequate load increases healing and an inadequate(over or underuse) load can deteriorate the tendon structure. Different eccentric training protocols have been used in the few studies conducted for people with rotator cuff tendinopathy. Further, the effects of the eccentric training for rotator cuff tendinopathy were only evaluated on pain, function and strength. Future studies should assess the effects of the eccentric training also on shoulder kinematics and muscle activity. Individualization of the exercise prescription, comprehension and motivation of the patients, and the establishment of specific goals, practice and efforts should allbe considered when prescribing the eccentric training. In conclusion, eccentric training should be used aiming improvement of the tendon degeneration, but more evidence is necessary to establish the adequate doseresponse and to determine long-term follow-up effects. | Paula R Camargo Francisco Alburquerque-Sendín Tania F Salvini | 2014 | World Journal of Orthopedics2014，5，5： | 5 |
| 3 | Effects of the Use of Theoretical Versus Theoretical-practical Training on CPR显示文摘 | Miotto H C Camargos F R Ribeiro C V | 2010 | Arq Bras Cardiol2010，95，3： | 1 |
| 4 | Influences of secondary phases on ferroelectric properties of Bi(Na,K)Ti O3 ceramics显示文摘 | RAMAJO L CAMARGO J RUBIO-MARCOS F | 2015 | Ceramics International2015，41，4： | 1 |
| 5 | An AFLP marker linked to the Pm-I gene that confers resistance to Podosphaera xanthii race 1 in Cucumis melo显示文摘 | Teixeira A P M Baeerto F A S Camargo L E A | 2008 | Genetics and Molecular Biology2008，31，2： | 1 |
| 6 | Comparative bioremediation of soils contaminated with diesel oil by natural attenuation,biostimulation and bioaugmentation显示文摘 | Bento F M Camargo F A Okeke B C | 2005 | Bioresource technology2005，96，： | 1 |
| 7 | Polycyclic aromatic hydrocarbons in Brazilian vegetables and fruits显示文摘 | Rojo Camargo M C Toledo M C F | 2003 | Food Control2003，14，1： | 1 |
| 8 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 9 | Molec- ular epidemiology of Brazilian pseudorabies viral isolates 显示文摘 | FONSECA A J CAMARGOS M F De OLIVEIRA A M | 2010 | Vet Microbio12010，141，34： | 1 |
| 10 | Wake-up stroke:clinical and neuroimaging characteristics显示文摘 | SILVA G S LIMA F O CAMARGO E C | 2010 | Cerebrovasc Dis2010，29，4： | 1 |
| 11 | DNA methylation patterns in bladder cancer and washing cell sediments:a perspective for tumor recurrence detection显示文摘 | Negaes P D Favaro F P Camargo J L | 2008 | BMC Cancer2008，8，： | 1 |
| 12 | Diagnostic accuracy of sonohysterography, transvaginal sonography, and hysterosalpingo-graphy in patients with uterine cavity diseases显示文摘 | Soares S R Barbosa bos Reis M M Camargos A F | 2000 | FertilSteril2000，73，2： | 1 |
| 13 | Fermentative and chemical characteristics of marandugrass silage submitted to four compaction pressures显示文摘 | Camargo do Amaral R Bernardes T F Siqueira G R | 2007 | Revista Brasileira de Zootecnia2007，，3： | 1 |
| 14 | The effects of foot position on the performance of the sit-to-stand move- ment with chronic stroke subjects 显示文摘 | Camargos AC Rodrigues-de-Paula-Goulart F Teixeira-Salmela LF | 2009 | Arch Phys Med Rehabil2009，90，2： | 1 |
| 15 | Diagnostic accuracy of sonohysterography, transvaginal sonography, and hysterosalpingography in patients 显示文摘 | Soares S R Barbosa dos Reis M M Camargos A F | 2000 | Fertil Steril2000，73，2： | 1 |
| 16 | Comparative bioremediation of soils contaminated with diesel oil by natural attenuation, biostimulation and bioaugmentation 显示文摘 | Bento F M Camargo F A O Okeke B C | 2005 | Bioresource Technology2005，96，9： | 1 |
| 17 | Evaluation of dermatological effects of cosmetic formulations containing Sacchromy- ces cerevisiae extract and vitamins 显示文摘 | GASPAR L R CAMARGO JR F B GIANETI M D | 2008 | Food and Chemical Toxicology2008，，46： | 1 |
| 18 | Chromate reduction by chromium-resistant bacteria isolated from soils contaminated with dichromate显示文摘 | CAMARGO F A O BENTO F M OKEKE B C | 2003 | ] Environ Qual2003，32，2： | 1 |
| 19 | Oct4ex-pression is not required for mouse somatic stem cell self-re-newal 显示文摘 | Lengner C J Camargo F D Hochedlinger K | 2007 | Cell Stem Cell2007，1，4： | 1 |
| 20 | Evaluation of dermatological effects of cosmetic formulations containing Sacchromyces cerevisiae extract and vitamins 显示文摘 | GASPAR L R CAMARGO JR F B GIANETI M D | 2008 | Food and Chemical Toxicology2008，46，： | 1 |
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