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| 1 | Prunus genetics and applications after de novo genome sequencing:achievements and prospects显示文摘Prior to the availability of whole-genome sequences,our understanding of the structural and functional aspects of Prunus tree genomes was limited mostly to molecular genetic mapping of important traits and development of EST resources.With public release of the peach genome and others that followed,significant advances in our knowledge of Prunus genomes and the genetic underpinnings of important traits ensued.In this review,we highlight key achievements in Prunus genetics and breeding driven by the availability of these whole-genome sequences.Within the structural and evolutionary contexts,we summarize:(1)the current status of Prunus whole-genome sequences;(2)preliminary and ongoing work on the sequence structure and diversity of the genomes;(3)the analyses of Prunus genome evolution driven by natural and man-made selection;and(4)provide insight into haploblocking genomes as a means to define genome-scale patterns of evolution that can be leveraged for trait selection in pedigree-based Prunus tree breeding programs worldwide.Functionally,we summarize recent and ongoing work that leverages whole-genome sequences to identify and characterize genes controlling 22 agronomically important Prunus traits.These include phenology,fruit quality,allergens,disease resistance,tree architecture,and self-incompatibility.Translationally,we explore the application of sequence-based marker-assisted breeding technologies and other sequence-guided biotechnological approaches for Prunus crop improvement.Finally,we present the current status of publically available Prunus genomics and genetics data housed mainly in the Genome Database for Rosaceae(GDR)and its updated functionalities for future bioinformatics-based Prunus genetics and genomics inquiry. | Maria JoséAranzana Véronique Decroocq Elisabeth Dirlewanger Iban Eduardo Zhong Shan Gao Ksenija Gasic Amy Iezzoni Sook Jung Cameron Peace Humberto Prieto Ryutaro Tao Ignazio Verde Albert G.Abbott Pere Arús | 2019 | Horticulture Research2019，6，1： | 8 |
| 2 | Black tea polyphenols mimic insulin/insulin-like growth factor-1 signalling to the longevity factor FOXOIa显示文摘 | Cameron AR Anton S Melville L | 2008 | Aging ceU2008，7，： | 1 |
| 3 | Significance ofmesangial IgM deposition inminimal change'nephrotic syn-drome显示文摘 | Vilches AR Turner DR Cameron JS | 1982 | Lab Invest1982，46，1： | 1 |
| 4 | Prevalence of columnar-lined (Barrett's)esophagus:comparison of populationbased clinical and autopsy findings显示文摘 | CAMERON AJ ZINSMEISTER AR BALLARD DJ | 1990 | Gastroenterology1990，99，： | 1 |
| 5 | Relationship between milk production and somatic cell count in dairy cows in east Gippsland显示文摘 | Cameron AR Anderson GA | 1993 | Aust Vet1993，70，： | 1 |
| 6 | The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a显示文摘 | Cameron AR Wallace K Logie L | 2012 | Biochem J2012，443，1： | 1 |
| 7 | The effect of time-dependent deformation of viscoelastic hydrogels on myogenic induction and Racl activity in mesenchymal stem cells显示文摘 | Cameron AR Frith JE Gomez GA etal | 2014 | Biomaterials2014，35，6： | 1 |
| 8 | The influence of substrate creep on mesenchymal stem cell behaviour and phenotype 显示文摘 | Cameron AR Frith JE Cooper-White JJ | 2011 | Biomaterials2011，32，26： | 1 |
| 9 | Insulin-like growth factor binding proteins IGFBP3,IGFBP4,and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer显示文摘 | Walker G MacLeod K Williams AR Cameron DA Smyth JF Langdon SP | | 0，，05： | 1 |
| 10 | Vitamin B12 : how the problem of its biosynthesis was solved 显示文摘 | Blanche F Cameron B Crouzet J Debussche L ThibautD Vuilhorgne M Leeper FJ Battersby AR | 1995 | Chem IntEd Engl1995，34，： | 1 |
| 11 | oral polio vaccine and intussusception:a data linkage study using records for vaccination and hospitalization显示文摘 | Cameron JC Walsh D Finlayson AR | 2006 | Am J Epidemiol2006，163，6： | 1 |
| 12 | Effects of bound versus soluble pentosan polysulphate in PEG/HA-based hydrogels tailored for intervertebral disc regeneration显示文摘 | Frith JE Menzies DJ Cameron AR | 2014 | Biomaterials2014，35，4： | 1 |
| 13 | Exercise and the immune response显示文摘 | Cameron K Morton AR | 1988 | Sports Med1988，，5： | 1 |
| 14 | Black tea polyphenols mimic insulin/insulin-like growth factor-1 signalling to the longevity factor FOXOla显示文摘 | Cameron AR Anton S Melville L | 2008 | Aging cell2008，7，： | 1 |
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