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| 1 | MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma显示文摘Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer. | Cameron M Smith David I Watson Michael Z Michael Damian J Hussey | 2010 | World Journal of Gastroenterology2010，16，5： | 23 |
| 2 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 3 | Use of the human dive reflex for the management of supraventricular tachycardia: a review of the literature显示文摘 | Smith G Morgans A Taylor D M Cameron P | 2012 | Emerg Med J2012，29，： | 1 |
| 4 | Exercise diet and skeletal muscle gene expression显示文摘 | Hargreaves M Cameron Smith D | 2002 | Med Sci Sports Exerc2002，34，9： | 1 |
| 5 | Atomic layer deposition of SiO2 and TiO2 in alumina tubular membranes:pore reduction and effect of surface species on gas transport显示文摘 | Cameron M A Gartland I P Smith J A | | 0，，： | 1 |
| 6 | Growth of human stem cell-derived neurons on solid three-dimensional polymers显示文摘 | Hayman M W Smith K H Cameron N R Przyborski S A | 2005 | Biochem Biophys Methods2005，62，： | 1 |
| 7 | Growth of human stem cell-derived neurons on solid three-dimensional polymers显示文摘 | Smith K H Cameron N R | 2005 | Biochem Biophys Methods2005，62，： | 1 |
| 8 | On the mechanism of CH3 radical formation in hot filament activated CH4/H2 and C2H2/H2 gas mixtures显示文摘 | SMITH J A CAMERON E ASHFOLDA M N R | 2001 | Diamond and Related Materials2001，10，37： | 1 |
| 9 | Effects of exercise on glut4 and glycogenin gene expression in human skeletal muscle显示文摘 | KRANIOU Y CAMERON SMITH D MISSO M | 2000 | J Appl Physiol2000，88，2： | 1 |
| 10 | Genetic manipulation of intraspinal plasticity after spinal cord injury alters the severity of autonomic dysreflexia显示文摘 | Cameron A A Smith G M Randall D C | 2006 | J Neurosci2006，26，11： | 1 |
| 11 | Atomic layer deposition of SiO2 and TiO2 in alumina tubular membranes:pore reduction and effect of surface species on gas transport显示文摘 | Cameron M A Gartland I P Smith J A | | 0，，19： | 1 |
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