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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Tamoxifen - associated steatohepatitis-report of three cases显示文摘 | Pinto HC Baptista A Camilo ME | 1995 | J Hepatol1995，23，1： | 1 |
| 3 | Non-alcoholic fatty liver: another feature of metabolic syndrome?显示文摘 | Cortez-Pinto H Camilo ME Baptiste A | 1999 | Clin Nutr1999，18，6： | 1 |
| 4 | Synthesis and properties of hydrophilic networks based on poly (ethylene glycol) and β-eyclodextrin 显示文摘 | Luis C Camilo A Ramirez D | 2007 | Macromol Chem Phys2007，208，8： | 1 |
| 5 | Gas phase hydrogenation of maleic anhydride at low pres- sure over silica-supported cobalt and nickel catalysts 显示文摘 | Meyer Camilo I Regenhardt Silvina A Marchi Alberto J | 2012 | Applied Catalysis A: General2012，，： | 1 |
| 6 | Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans显示文摘 | RICHARD A BONE JOHN T LANDRUM LUIS H GUERRA and CAMILO A RUIZ | 2003 | J Nutr2003，，133： | 1 |
| 7 | Temperature correction and strut loads in Central Artery excavations 显示文摘 | Hashash Youssef M A Marulanda Camilo Kershaw Kyle A | 2003 | Journal of Geotechnical and Geoenvironmental Engineering2003，129，6： | 1 |
| 8 | Nonalcoholic steatohepatitis:clinicopathological comparison with alcoholic hepatitis in ambulatory and hospitalized patients显示文摘 | Pinto HC Baptista A Camilo ME | 1996 | Dig Dis Sci1996，41，： | 1 |
| 9 | Novel Cellular Genes Essential for Transfomuation of Endothelial Cells by Kapesi's SarcomaAssociated Herpesvims显示文摘 | CAMILO R REBECCA R SHANE M A | 2005 | Cancer Res2005，65，12： | 1 |
| 10 | Old Hypertension:Another Feature of the Metallic Syndrome显示文摘 | Camilo ME Baptista A | 1999 | Clin Nutr1999，18，： | 1 |
| 11 | Voltammetric and speetrophotometric techniques for the determination of the antihypertensive drug Prazosin in urine and formulations显示文摘 | ADELA A SUSANA F B CAMILO E | 1999 | J Pharm Biomed Anal1999，21，： | 1 |
| 12 | The identification of novel, high affinity AQP9 inhibitors in an intracellular binding site显示文摘 | S?ren J. Wacker Camilo Aponte-Santamaría Per Kjellbom S?ren Nielsen Bert L. de Groot Michael Rützler | 2013 | Molecular Membrane Biology2013，，3： | 1 |
| 13 | non - alcoholic fatty liver:another feature of the metaolic syndrome显示文摘 | Corter - Pinto H Camilo ME Baptista A | 1999 | Clin nutr1999，18，： | 1 |
| 14 | Nonalcoholic fatty liver: another feature of the metabolic syndrome显示文摘 | Cortez PH Camilo ME Baptista A et at | 1999 | Clin Nutr1999，18，6： | 1 |
| 15 | Achieving CO2 Reductions in Colombia:Effects of Carbon Taxes and Abatement Targets显示文摘 | Silvia Calderóna Andrés Camilo Alvareza Ana María Loboguerrerob SantiagoArangoc Katherine Calvind Tom Kobere Kathryn Daenzerf Karen Fisher-Vandenf | 2015 | Energy Economics2015，，5： | 1 |
| 16 | A critical approach to nutritional assessment in critically ill patients显示文摘 | Ravasco P Camilo M E Gouveia-Oliveira A | 2002 | Clin Nutr2002，21，1： | 1 |
| 17 | Plant growth promotion by Bacillus amyloliquefaciens FZB45 depends on inoculum rate and P-related soil properties显示文摘 | Camilo A R Joseph W K | | 0，，8： | 1 |
| 18 | A critical approach to nutritional assessment in critically ill patients显示文摘 | Ravesco P Camilo M E Gouveia-oliveira A | 2002 | Clin Nutr2002，21，1： | 1 |
| 19 | Timed concurrent constraint programming for analysing biological systems显示文摘 | Julian Gutierrez Jorge A Perez Camilo Rueda Frank D Valencia | 2007 | Electronic Notes in Theoretical Computer Science2007，171，2： | 1 |
| 20 | Nonalcoholic fatty liver:another feature of the metabolic syndrome 显示文摘 | Camilo ME Baptista A | 1999 | Clin Nutr1999，18，： | 1 |
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