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| 1 | Understanding the medial ulnar collateral ligament of the elbow: Review of native ligament anatomy and function显示文摘The medial ulnar collateral ligament complex of the elbow, which is comprised of the anterior bundle [AB, more formally referred to as the medial ulnar collateral ligament(MUCL)], posterior(PB), and transverse ligament, is commonly injured in overhead throwing athletes. Attenuation or rupture of the ligament results in valgus instability with variable clinical presentations. The AB or MUCL is the strongest component of the ligamentous complex and the primary restraint to valgus stress. It is also composed of two separate bands(anterior and posterior) that provide reciprocal function with the anterior band tight in extension, and the posterior band tight in flexion. In individuals who fail co-mprehensive non-operative treatment, surgical repair or reconstruction of the MUCL is commonly required to restore elbow function and stability. A comprehensive understanding of the anatomy and biomechanical properties of the MUCL is imperative to optimize reconstructive efforts, and to enhance clinical and radiographic outcomes. Our understanding of the native anatomy and biomechanics of the MUCL has evolved over time. The precise locations of the origin and insertion footprint centers guide surgeons in proper graft placement with relation to bony anatomic landmarks. In recent studies, the ulnar insertion of the MUCL is described as larger than previously thought, with the center of the footprint at varying distances relative to the ulnar ridge, joint line, or sublime tubercle. The purpose of this review is to consolidate and summarize the existing literature regarding the native anatomy, biomechanical, and clinical significance of the entire medial ulnar collateral ligament complex, including the MUCL(AB), PB, and transverse ligament. | Joshua R Labott William R Aibinder Joshua S Dines Christopher L Camp | 2018 | World Journal of Orthopedics2018，9，6： | 4 |
| 2 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 3 | Evaluation and treatment of internal impingement of the shoulder in overhead athletes显示文摘One of the most common pathologic processes seen in overhead throwing athletes is posterior shoulderpain resulting from internal impingement. 'Internal impingement' is a term used to describe a constellation of symptoms which result from the greater tuberosity of the humerus and the articular surface of the rotator cuff abutting the posterosuperior glenoid when the shoulder is in an abducted and externally rotated position. The pathophysiology in symptomatic internal impingement is multifactorial,involving physiologic shoulder remodeling,posterior capsular contracture,and scapular dyskinesis. Throwers with internal impingement may complain of shoulder stiffness or the need for a prolonged warm-up,decline in performance,or posterior shoulder pain. On physical examination,patients will demonstrate limited internal rotation and posterior shoulder pain with a posterior impingement test. Common imaging findings include the classic 'Bennett lesion' on radiographs,as well as articular-sided partial rotator cuff tears and concomitant SLAP lesions. Mainstays of treatment include intense non-operative management focusing on rest and stretching protocols focusing on the posterior capsule. Operative management is variable depending on the exact pathology,but largely consists of rotator cuff debridement. Outcomes of operative treatment have been mixed,therefore intense non-operative treatment should remain the focus of treatment. | Keith T Corpus Christopher L Camp David M Dines David W Altchek Joshua S Dines | 2016 | World Journal of Orthopedics2016，7，12： | 2 |
| 4 | Synthesis of Both Enantiomers of Baclofen Using (R)-and (S)-N-phenylpantolactam as Chiral Auxiliaries显示文摘 | Camps P Munoz-Torrero D Sánchez L | 2004 | Tetrahedron:Asymmetry2004，15，： | 1 |
| 5 | Bile duct injury during laparoscopic cholecystectomy Myth or reality of the learning curve显示文摘 | Calvete J Sabater L Camps B | 2000 | Surg Endosc2000，14，： | 1 |
| 6 | Inhibition of Cell Di-vision in Escherichia coli by Electrolysis Products froma Platinum Electrode 显示文摘 | Rosenberg B Camp L Krigas T | 1965 | Nature1965，205，： | 1 |
| 7 | A role for XRCC2gene polymorphisms in breast cancer risk and survival显示文摘 | Lin W Y Camp N J Cannon-Albright L A | 2011 | J Med Genet2011，48，7： | 1 |
| 8 | The inhibition of growth or cell division in Escherichia coli by different ionic species of platinum(Ⅳ) complexes显示文摘 | Rosenberg B Van Camp L Grimley EB | 1967 | J Biol Chem1967，242，： | 1 |
| 9 | External ven- tricular drain insertion accuracy: is there a need for change in practice? 显示文摘 | Toma A K Camp S Watkins L D | 2009 | Neurosurgery2009，65，6： | 1 |
| 10 | Subsurface damage and polishing compound affect the 355 nm laser damage threshold of fusedsilica surfaces显示文摘 | Camp D W Kozlowski M R Sheehan L M | 1998 | Proceedings of SPIE1998，3244，： | 1 |
| 11 | Bile duct injury during laparoscopic cholecystectomy: myth or reality of the learning curve 显示文摘 | Calvete J Sabater L Camps B | 2000 | ? Surg Endosc2000，14，7： | 1 |
| 12 | Fact ors affecting the enhancement of oxidative stress tolerance in transgenic tobacc o overexpressing manganese superoxide dismutase in the chloroplasts显示文摘 | Capiau K Camp W V Montagu M V Sybesma C and Inzé D | 1995 | Plant P hysiol1995，107，： | 1 |
| 13 | Tissue microarray: a new technology for amplification of tissue resources显示文摘 | Rimm D L Camp R L Charette L A | 2001 | Cancer J2001，7，1： | 1 |
| 14 | Platinum compounds:a new class of potent antitumour our agents显示文摘 | ROSENBERG B VAN CAMP L TROSKO J E | 1969 | Nature1969，222，： | 1 |
| 15 | In vitro apical leakage of system B compared with other filling techniques显示文摘 | Pommel L Jacquot B Camps J | 2001 | J Endod2001，27，5： | 1 |
| 16 | Corrective osteotomies in malunions of the distal radius:do we get what we planned显示文摘 | von Campe A Nagy L Arbab D | 2006 | Clin Orthop Relat Res2006，450，： | 1 |
| 17 | Effect ofoxygen on the anaerobic methanotroph ‘ CandidatusMethylomirabilis oxyfera,: kinetic and transcriptional analysis 显示文摘 | LUESKEN F A WU M L OP DEN CAMP H J M | 2012 | Environmental Microbiology2012，14，4： | 1 |
| 18 | Strategic Entrepreneurship: Entrepreneurial Strategies for Wealth Creation 显示文摘 | Hitt M A Ireland R D Camp S M Sexton D L | 2001 | Strategic Management Journal2001，22，67： | 1 |
| 19 | Enhancement of o xidative stress tolerance in transgenic tobacco plants overproduction Fe-superox ide dismutase in chloroplasts显示文摘 | Capiau K Montagu M V Inzé D Slooten L | 1996 | Plant Physiol1996，112，： | 1 |
| 20 | In vitro apical leakage of system B comparedwith other filling techniques 显示文摘 | Pommel L Camps J | 2001 | J Endod2001，27，7： | 1 |
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