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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 3 | Rapid induction of multiple resistance mechanisms in Aspergillus fumigatus during az- ole therapy: a case study and review of the literature显示文摘 | Camps SM van der Linden JW Li Y | 2012 | Antimi- crob Agents Chemother2012，56，1： | 1 |
| 4 | Herpes Simplex Virus Type 1/adeno-associated Virus Rep+ Hybrid Amplicon Vector Improves the Stability of Transgene Expression in Human Cells by Site-specific Integration显示文摘 | Camp SM Niwano M | 2002 | Journal of Virology2002，76，： | 1 |
| 5 | Discovery of a HapE mutation that causes azole resistance in Aspergillus fumigatu' through whole genome sequencing and sexual crossing 显示文摘 | Camps SM Dutilh BE Arendrup MC | 2012 | PLoS One2012，7，50： | 1 |
| 6 | Synthetic analogsof FTY720 ethyl )-1,3-propanediol] differentially regulate pulmonary vascularpermeability in vivo and in vitro 显示文摘 | Camp SM Bittman R Chiang ET | 2009 | J Pharmacol2009，，1： | 1 |
| 7 | Virological diagnosis in community-acquired pneumonia in immunocompromised patients显示文摘 | Camps SM Cervera C Pumarola T | 2008 | Eur Respir J2008，31，： | 1 |
| 8 | Strategic Entrepreneurship, Entrepreneurial Strategies for Wealth Creation 显示文摘 | Hitt MA Ireland RD Camp SM Sexton DL | 2001 | Strategic Management Journal2001，，22： | 1 |
| 9 | Diabetic neuropathy : an intensive review显示文摘 | Duby JJ Camp bell RK Setter SM | 2004 | Am J Health Syst Pharm2004，61，2： | 1 |
| 10 | Triazole fungicides can induce crossresistanceto medical triazoles in Aspergillusfumigatus显示文摘 | SNELDERS E CAMPS SM KARAWAJCZYKA | 2012 | PLoS One2012，7，31： | 1 |
| 11 | Gender and the diagnosis, management,and surveillance of obstructive pulmonary disease 显示文摘 | Camp PG Goring SM | 2007 | Proc AmThorac Soc2007，4，8： | 1 |
| 12 | Targeted transgene integration into transgenic mouse fibroblasts carrying the full-length human AAVS1 locus mediated by HSV/AAV rep ( + ) hybrid amplicon vector 显示文摘 | Bakowska JC Di Maria MV Camp SM | 2003 | Gene Ther2003，10，19： | 1 |
| 13 | Molecular epidemiology of Aspergillus fumigatusisolates harboring the TR34/L98H azole resistancemechanism显示文摘 | CAMPS SM RIJS AJ KLAASSEN CH | 2012 | J Clin Microbiol2012，50，8： | 1 |
| 14 | Timing of pulmonary emboli after trauma:implications for retrievable vena cava filters显示文摘 | Sing RF Camp SM Heniford BT | | 0，，04： | 1 |
| 15 | Aspergillosis due to voriconazole highly resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles 显示文摘 | van der Linden JW Camps SM Kampinga GA Arends JP Debets-Ossenkopp YI Haas PI Rijnders BJ Kuijper EJ van Tiel PH Varga J Karawajczyk A Zoll J Melchers WJ Verweij PE | 2013 | Clin Infect Dis2013，57，4： | 1 |
| 16 | Mutations in the Wolfram syndrome 1 gene (WFS1) are a common cause of low frequency sensorineural hearing loss显示文摘 | Bespalova IN Van Camp G Bom SJ Brown DJ Cryns K DeWan AT Erson AE Flothmann K Kunst HP Kurnool P Sivakumaran TA Cremers CW Leal SM Burmeister M Les-perance MM | | 0，，22： | 1 |
| 17 | Herpes simplex virus typel-adeno-associated virus rep (+) hybrid amplicon vector improves the stability of transgene expression in human cells by site-specific integration显示文摘 | Wang Y Camp SM Niwano M | 2002 | J Virol2002，76，14： | 1 |
| 18 | Mutations in the Wolfram syndrome 1 gene (WFS1) are a common cause of low frequency sensorineural hearing loss显示文摘 | Bespalova IN Van Camp G Bom SJ Brown DJ Cryns K DeWan AT Erson AE Flothmann K Kunst HP Kurnool P Sivaku-maran TA Cremers CW Leal SM Burmeister M Lesperance MM | | 0，，22： | 1 |
| 19 | Virological diagnosis in community-acquired pneumonia in immunocompromised patients显示文摘 | Camps SM Cervera C Pumarola T | 2008 | Eur Respir J2008，31，3： | 1 |
| 20 | Comprehension of a prototype over-the-counter label for an emergency contraceptive pill product显示文摘 | RAYMOND EG DALEBOUT SM CAMP SI | 2002 | Obstet Gynecol2002，100，2： | 1 |
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