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| 1 | Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease:Need for mucosal viral load measurement显示文摘AIM:To evaluate the best diagnostic technique and risk factors of the human Cytomegalovirus(HCMV)and Epstein-Barr virus(EBV)infection in inflammatory bowel disease(IBD).METHODS:A cohort of 40 IBD patients(17 refractory)and 40 controls underwent peripheral blood and endoscopic colonic mucosal sample harvest.Viral infection was assessed by quantitative real-time polymerase chain reaction and immunohistochemistry,and correlations with clinical and endoscopic indexes of activity,and risk factors were investigated.RESULTS:All refractory patients carried detectable levels of HCMV and/or EBV mucosal load as comparedto 13/23(56.5%)non-refractory and 13/40(32.5%)controls.The median DNA value was significantly higher in refractory(HCMV 286 and EBV 5.440 copies/105cells)than in non-refractory(HCMV 0 and EBV 6copies/105 cells;P<0.05 and<0.001)IBD patients and controls(HCMV and EBV 0 copies/105 cells;P<0.001 for both).Refractory patients showed DNA peak values≥103 copies/105 cells in diseased mucosa in comparison to non-diseased mucosa(P<0.0121 for HCMV and<0.0004 for EBV),while non-refractory patients and controls invariably displayed levels below this threshold,thus allowing us to differentiate viral colitis from mucosal infection.Moreover,the mucosal load positively correlated with the values found in the peripheral blood,whilst no correlation with the number of positive cells at immunohistochemistry was found.Steroid use was identified as a significant risk factor for both HCMV(P=0.018)and EBV(P=0.002)colitis.Finally,a course of specific antiviral therapy with ganciclovir was successful in all refractory patients with HCMV colitis,whilst refractory patients with EBV colitis did not show any improvement despite steroid tapering and discontinuation of the other medications.CONCLUSION:Viral colitis appeared to contribute to mucosal lesions in refractory IBD,and its correct diagnosis and management require quantitative real-time polymerase chain reaction assay of mucosal specimens. | Rachele Ciccocioppo Francesca Racca Stefania Paolucci Giulia Campanini Lodovica Pozzi Elena Betti Roberta Riboni Alessandro Vanoli Fausto Baldanti Gino Roberto Corazza | 2015 | World Journal of Gastroenterology2015，21，6： | 12 |
| 2 | Efficacy of Interpersonal Therapy-group Format Adapted to Post-traumatic Stress Disorder:an Open-label Add-on Trial显示文摘 | Campanini RF Schoedl AF Pupo MC | 2010 | Depress Anxiety(S1520-6394)2010，27，1： | 1 |
| 3 | Correlation of viral load as determined by real - time RT - PCR and clinical characteristics of respiratory syncytial virus lower respiratory tract infections in early infancy 显示文摘 | Gerna G Campanini G Rognoni V | 2008 | J Clin Virol2008，41，1： | 1 |
| 4 | Main and interactive effects of shiftwork, age and work stress on health in an Italian sample of heahhcare workers 显示文摘 | Conway P M Campanini P Sartori S | 2008 | Appl Ergon2008，39，5： | 1 |
| 5 | Changing cir- culation rate of human metapneumovirus strains and types among hospitalized pediatric patients during three consecutive winter-spring seasons显示文摘 | Gerna G Campanini G Rovida F etal | 2005 | Arch Vir- ol2005，150，11： | 1 |
| 6 | Workplace bullying and sickness absenteeism显示文摘 | Campanini P Conway PM Neri L | 2013 | Epidemiol Prev2013，37，1： | 1 |
| 7 | A novel featureless ap- proach to mass detection in digital mammograms based on support vector machines 显示文摘 | R Campanini E Dongiovanni E Iampieri | 2002 | Physics Medicine Biology2002，49，6： | 1 |
| 8 | Psychological stress in nurses' relationships with HIVinfected patients:the risk of burnout syndrome显示文摘 | VISINTINI R CAMPANINI E FOSSATI A | 1996 | AIDS Care1996，8，2： | 1 |
| 9 | Genetic variability of human eoronavirus OC43-, 229E-, and NL63-1ike strains and their association with lower respiratory tract infections of hospitalized infants and immunocompromised patients显示文摘 | Gerna G Campanini G Rovida F | 2006 | J Med Virol2006，78，7： | 1 |
| 10 | Psychologicalstress in nurses'relationshps with HIV 2in fected patients: the risk of burnout syndrome显示文摘 | Visintini R Campanini E Fossati A | 1996 | Care1996，8，2： | 1 |
| 11 | Awake versus sleep endoscopy: personal experience in 250 OSAHS patients 显示文摘 | Campanini A Canzi P de Vito A | 2010 | Acta Otorhinolaryngol hal2010，30，2： | 1 |
| 12 | Hypertension in pregnancy显示文摘 | LUNATI F DUGNANI M CAMPANINI M | 2008 | Recenti Prog Med2008，99，9： | 1 |
| 13 | Correlation of viral load as determined by real-time RT-PCR and clinical characteristics of respiratory syncytial virus lower respiratory tract infections in early infancy显示文摘 | GERNA G CAMPANINI G ROGNONI V | 2008 | J Clin Virol2008，41，1： | 1 |
| 14 | The human bocavirus role in acute respiratory tract infections of pediatric patients as defined by viral load quantification 显示文摘 | Gerna G Piralla A Campanini G | 2007 | New Microbiol2007，30，： | 1 |
| 15 | Diagnostic role of videothoracoseopy in mediastinal diseases 显示文摘 | Solaini L Bagioni P Campanini A | 1998 | Eur J Cardiothorae Surg1998，13，： | 1 |
| 16 | Recommendations for the management of mixed cryoglobulinemia syndrome in hepatitis C virus-infected patients显示文摘 | Maurizio Pietrogrande Salvatore De Vita Anna Linda Zignego Pietro Pioltelli Domenico Sansonno Salvatore Sollima Fabiola Atzeni Francesco Saccardo Luca Quartuccio Savino Bruno Raffaele Bruno Mauro Campanini Marco Candela Laura Castelnovo Armando Gabrielli | 2011 | Autoimmunity Reviews2011，，8： | 1 |
| 17 | Psychological stress in nurses'relationshops with HIV infected patients:the risk of burnout syndrome显示文摘 | Visintini R Campanini E Fossati A | 1996 | AIDS Care1996，8，2： | 1 |
| 18 | Aggressive clear cell chondrosarcomas:do distinctive characteristics exist:a report of 4 cases显示文摘 | Corradi D Bacchini P Campanini N Bertoni F | 2006 | Arch Pathol Lab Med2006，130，11： | 1 |
| 19 | Psychological stress in nurses' relationships with HIV - infected patients: The risk of burnout syndrome 显示文摘 | Visinitini R Campanini E Fossati A | 1996 | AIDS Care1996，，8： | 1 |
| 20 | Awake versus sleep endoscopy: personal experience in 250 OSAHS patients显示文摘 | Campanini A Canzi P De Vito A | 2010 | Acta Otorhinolaryngol Ital2010，30，2： | 1 |
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