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| 1 | Intestinal inflamma-tion measured by fecal neopterin in Gambian children with enter- opathy: association with growth failure, Giardia lamblia, and in- testinal permeability 显示文摘 | Campbell DI Mcphail G Lunn PG | 2004 | J Pediatr Gastroenterol Nutr2004，39，2： | 1 |
| 2 | A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis显示文摘Several developmental stages of spermatogenesis are transcriptionally quiescent which presents major challenges associated with the regulation of gene expression. Here we identify that the zygotene to pachytene transit!on is not only associated with the resumption of transcription but also a wave of programmed mRNA degradation that is essential for meiotic progress!on. We explored whether terminal uridydyl transferase 4-(TUT4-) or TUT7-mediated 3' mRNA uridylation contributes to this wave of mRNA degradation during pachynema. Indeed, both TUT4 and TUT7 are expressed throughout most of spermatogenesis, however, loss of either TUT4 or TUT7 does not have any major impact upon spermatogenesis. Combined TUT4 and TUT7 (TUT4/7) deficiency results in embryonic growth defects, while conditional gene targeting revealed an essential role for TUT4/7 in pachytene progression. Loss of TUT4/7 results in the reduction of miRNA, piRNA and mRNA 31 uridylation. Although this reduction does not greatly alter miRNA or piRNA expression, TUT4/7-mediated uridylation is required for the clearanee of many zygotene-expressed transcripts in pachytene cells. We find that TUT4/7-regulated transcripts in pachytene spermatocytes are characterized by having long 3Z UTRs with length-adjusted enrichment for AU-rich elements. We also observed these features in TUT4/7-regulated maternal transcripts whose dosage was recently shown to be essential for sculpting a functional maternal transcriptome and meiosis. Therefore, mRNA 3Z uridylation is a critical determinant of both male and female germline transcriptomes. In conclusion, we have identified a novel requirement for 3' uridylation-programmed zygotene mRNA clearanee in pachytene spermatocytes that is essential for male meiotic progression. | Marcos Morgan Yuka Kabayama Christian Much Ivayla Ivanova Monica Di Giacomo Tatsiana Auchynnikava Jack Michael Monahan Dimitrios Michael Vitsios Lina Vasiliauskaite Stefano Comazzetto Juri Rappsilber Robin Campbell Allshire Bo Torben Porse Anton James Enright Donal O'Carroll | 2019 | Cell Research2019，29，3： | 1 |
| 3 | Growth faltering in rural Gambian infants is associated with impaired small intestinal harrier function, leading to endotoxemia and systemic inflammation 显示文摘 | Campbell DI Elia M Lunn PG | 2003 | J Nutr2003，133，5： | 1 |
| 4 | Cisplatin ototoxicity in the Sprague Dawley rat evaluated by distortion product otoacoustic emissions显示文摘 | Hatzopoulos S Di Stefano M Campbell K C | 2001 | Audiology2001，40，： | 1 |
| 5 | Severe intestinal lymphangiectasia complicated by nephrotic syndrome treated by small bowel,liver,and kidney transplantation显示文摘 | Beath SV deVille de Goyet J | 2003 | J Pediatr Gastroenterol Nutr2003，36，2： | 1 |
| 6 | The African enigma:low prevalence of gastric atrophy,high prevalence of chronic inflammation in West African adults and children显示文摘 | Campbell DI Warren BF Thomas JE | | 0，，： | 1 |
| 7 | Assessment Of Myocardial Viability And Left Ventricular Function In Patients Supported By A Left Ventricular Assist Device显示文摘 | Deepak K. Gupta Hicham Skali Jose Rivero Patricia Campbell Leslie Griffin Colleen Smith Courtney Foster Brian Claggett Robert J. Glynn Gregory Couper Michael M. Givertz Mandeep R. Mehra Marcelo Di Carli Scott D. Solomon Marc A Pfeffer | 2014 | Journal of Heart and Lung Transplantation2014，，： | 1 |
| 8 | Regulation of epithelial Na+ channels by aldosterone:role of Sgk1显示文摘 | Lee IH Campbell CR Cook DI | | 0，，： | 1 |
| 9 | Regulation of epithelial Na+ channels by aldosterone: role of Sgjl 显示文摘 | Lee IH Campbell CR Cook DI | 2008 | Clin Exp Phamacol Physiol2008，35，2： | 1 |
| 10 | Rapid prototyping technology in orbital floor reconstruction: application in three patients 显示文摘 | Lim CG Campbell DI Clucas DM | 2014 | Craniomaxillofac Trauma Reconstr2014，7，2： | 1 |
| 11 | Antihypertensive therapy with losartan and fosinopril:efficacy in left ventricular hypertrophy regression显示文摘 | Campbell SV Rizzo V Di Maio F | 1998 | Am J Hypertens1998，11，12： | 1 |
| 12 | Regulation of epithelial Na + channels by aldosterone:role of Sgk1显示文摘 | Lee IH Campbell CR Cook DI | | 0，，： | 1 |
| 13 | Dislocation risk comparing surgical approach and 3 different head sizes in 2,250 hips显示文摘 | campbell D Cochrane L Rowley DI | 2006 | J Bone Joint Surg (Br)2006，88，2： | 1 |
| 14 | Regulation of epithelial Na^+ channels by aldosterone:role of Sgkl 显示文摘 | Lee IH Campbell CR Cook DI | 2008 | Clin Exp Pharmacol Physiol2008，35，2： | 1 |
| 15 | Temporo- mandibular joint synovial ehondromatosis with intracranial ex- tension: a review and observations of patient observed for 4 years 显示文摘 | Campbell DI De Silva RK De Silva H | 2011 | J Oral Maxillofac Surg2011，69，8： | 1 |
| 16 | Growth faltering in rural Gambian infants is associated with impaired small intestinal barrier function, leading to endotoxemia and systemic inflammation 显示文摘 | Campbell DI Elia M Lunn PG | 2003 | J Nutr2003，133，5： | 1 |
| 17 | Regional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs显示文摘 | Borhane Guezguez Clinton J.V. Campbell Allison L. Boyd Francis Karanu Fanny L. Casado Christine Di Cresce Tony J. Collins Zoya Shapovalova Anargyros Xenocostas Mickie Bhatia | 2013 | Cell Stem Cell2013，，： | 1 |
| 18 | Temporomandibular joint synovial chondromatosis with intracranial extension: a review and observations of patientobserved for 4 years显示文摘 | Campbell DI DeSilva RK DeSilva H | 2011 | J Oral Maxillofac Surg2011，69，8： | 1 |
| 19 | Environmental enteropathy: new targets for nutritional interventions 显示文摘 | McKay S Gaudier E Campbell DI | 2010 | Int Health2010，2，3： | 1 |
| 20 | Major cellular and physiological impacts of ocean acidification on a reef building coral显示文摘 | Kaniewska P Campbell P R Kline DI | 2012 | PLoS ONE2012，7，34： | 1 |
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