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| 1 | A retrograde apoptotic signal originating in NGF-deprived distal axons of rat sympathetic neurons in compartmented cultures显示文摘以前的调查后退幸存由神经生长因素(NGF ) 和另外的 neurotrophins 发信号支持了多样的机制,但是所有建议机制有在普通 retrogradely 传给 neuronal 细胞身体的幸存信号的产生。我们报导在轴突发现被本地 NGF 发信号压制一个 retrograde apoptotic 信号。从远侧的轴突的 NGF 退却独自是足够的激活 pro-apoptotic 抄写因素, c-jun,在房间身体。直接提供 NGF 给房间身体,从而恢复导致 NGF 的幸存的来源发信号,不能阻止 NGF 退却从远侧的轴突引起的 c-jun 激活。这是 c-jun 没在房间身体由于幸存信号的损失被激活的证据。而且,与用番红花作原料而制成的植物盐基堵住 axonal 运输禁止了建议 retrogradely 搬运的幸存的一个 retrogradely 搬运的 pro-apoptotic 信号,而非损失发信号的 NGF 剥夺引起的 c-jun 激活,引起的 c-jun 激活。另外的实验证明 c-jun, pro-caspase-3 劈开,和 apoptosis 的激活被蛋白质 kinase C 禁止者, rottlerin 和 chelerythrine 堵住,仅仅当适用于建议他们堵住轴突特定的 pro-apoptotic 信号的远侧的轴突时。rottlerin 敏感的机制被发现调整肝糖 synthase kinase 3 (GSK3 ) 活动。siRNA 的效果击倒,并且 GSK3 的药理学抑制建议 GSK3 为 NGF 剥夺引起的 apoptosis 被要求并且可以作为轴突 apoptotic 信号的一个 retrograde 搬运人工作。在被 neurotrophins 压制的轴突表明系统的 retrograde 死亡的存在为 neurodevelopment 并且为为 neurodegenerative 疾病和 neurotrauma 发现治疗有宽广含意。 | Sue-Ann Mok Karen Lund Robert B Campenot | 2009 | Cell Research2009，19，5： | 2 |
| 2 | Effects of the neurot rophins nerve groth factor, nerot roph in -3, and brain derived neurot rophic factor (BDNF) on neurite growth from adult sensory neurons in compartmented cultures显示文摘 | Kimpins ki K Campenot R B Mearow K | 1997 | Neu-robiol1997，33，4： | 1 |
| 3 | Retrograde transport of neurotrophins : fact and function 显示文摘 | Campenot R Maclnnis B | 2004 | Neurobiol2004，58，2： | 1 |
| 4 | Apolipoprotein E - con- taining lipoproteins protect neurons from apoptosis via a signaling pathway involving low - density lipoprotein receptor - related pro- tein - 1 显示文摘 | Hayashi H Campenot RB Vance DE | 2007 | J Neurosei2007，27，8： | 1 |
| 5 | Retrograde support of neuronal survival without retrograde transport of nerve growth factor 显示文摘 | Maclnnis BL Campenot RB | 2002 | Science2002，295，5559： | 1 |
| 6 | Retrograde transport of neurotrophins:fact and function显示文摘 | Campenot R B Maclnnis B L | 2004 | J Neurobiol2004，58，2： | 1 |
| 7 | Receptor binding,internalization,and retrograde transport of neurotrophic factors显示文摘 | Neet KE Campenot RB | | 0，，08： | 1 |
| 8 | Receptor binding,internalization,and ret rograde transport of neurotrophic factors显示文摘 | Neet KE Campenot RB | 2001 | Cell Mol Life Sci2001，58，8： | 1 |
| 9 | Effects of the Neurotro- phins Nerve Growth Factor, Neurotrophin-3, and Brain-DerivedNeurotrophic Factor (BDNF) on Neurite Growth from Adult Sensory Neurons in Compartmented Cultures显示文摘 | Kimpinski K Campenot RB Mearow K | 1997 | J Neurobiol1997，33，： | 1 |
| 10 | Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia 显示文摘 | Karten B Campenot RB Vance DE | 2006 | J Biol Chem2006，281，7： | 1 |
| 11 | Protection of neurons from apoptosis by apdipoproteln E-containing lipoprotcina does not require lipoprotein uptake and involves activation of phospholipase Cgammal and inhi- bition of calcineurin 显示文摘 | Hayashi H Campenot RB Vance DE ctal | 2009 | J Biol Ghem2009，284，29： | 1 |
| 12 | Receptor binding, internalization, and retrograde transport of neurotrophic factors Cell Mol Life Sci显示文摘 | Neet KE Campenot RB | 2001 | 58(8): 1021-10352001，58，8： | 1 |
| 13 | Protection of neurons from apoptosis by apolipoprotein E containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cgamma1 and inhibition of calcineurin显示文摘 | Hayashi H Campenot RB Vance DE | 2009 | J Biol Chem2009，284，29： | 1 |
| 14 | Apolipoprotein E-contai- ning lipoproteins protect neurons from apoptosis via a signaling path- way involving low-density lipoprotein receptor-related protein-1 显示文摘 | Hayashi H Campenot RB Vance DE | 2007 | J Neurosci2007，27，8： | 1 |
| 15 | Retrograde transport of nan-rotrophins: fact and function 显示文摘 | CAMPENOT RB MACINNIS BL | 2004 | J Neurobiol2004，58，： | 1 |
| 16 | Apolipoprotein E containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1显示文摘 | Hayashi H Campenot RB Vance DE | 2007 | J Neurosci2007，27，8： | 1 |
| 17 | Glial lipoproteins stimulate axon growth of central nervous system neurons in compartmented cultures显示文摘 | Hayashi H Campenot RB Vance DE | 2004 | J Biol Chem2004，279，14： | 1 |
| 18 | Synthesis ofbeta-tubulin, actin, and other proteins in axons of sympathetic neurons in compartmented cultures显示文摘 | Eng H Lund K Campenot RB | 1999 | J Neurosci1999，19，1： | 1 |
| 19 | Retrograde support of neuronal survival without retrograde transport of nerve growth factor 显示文摘 | Maclnnis B L Campenot R B | 2002 | Science2002，5559，： | 1 |
| 20 | A nerve growth factor-induced retrograde survival signal mediated by mechanisms downstream of TrkA 显示文摘 | Mok SA Campenot RB | 2007 | Neuropharmacology2007，52，2： | 1 |
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