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| 1 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 2 | Improvement of mechanical and corrosion properties of magnesium alloy by lead addition显示文摘 | CANDAN S UNAL M TURKMEN M KOC E TUREN Y CANDAN E | 2009 | Materials Science and Engineering A2009，501，： | 1 |
| 3 | Effects of titanium addi- tion on mechanical and corrosion behaviors of AZ91 magnesium alloy显示文摘 | CANDAN S UNAL M KOC E | 2011 | Journal of Alloys and Compounds2011，509，5： | 1 |
| 4 | Use of fuzzyrelations to produce landslide susceptibility map of alandslide prone area (West Black Sea Region,Turkey)显示文摘 | MURAT E CANDAN G | 2004 | Engineering Geology2004，75，： | 1 |
| 5 | Abrasive wear behaviour of Al-SiC composites produced by pressure infiltration technique显示文摘 | Candan E Ahlatci H Gimenoglu H | 2001 | Wear2001，247，2： | 1 |
| 6 | Increased Colonic Intraepithelial Lymphocytes in Patients With Hashimoto’s Thyroiditis显示文摘 | Mehmet Cindoruk Candan Tuncer Ay?e Dursun Ilhan Yetkin Taner Karakan Nuri ?akir Irfan Soykan | 2002 | Journal of Clinical Gastroenterology2002，，3： | 1 |
| 7 | Abrasive wear behaviour of A1- SiC composites produced by pressure infiltration technique 显示文摘 | Candan E Ahlatci H | 2001 | Wear2001，247，： | 1 |
| 8 | Improvement of mechanical and corrosion properties of magnesium alloy by lead addition 显示文摘 | CANDAN S UNAL M TURKMEN M KOC E TUREN Y CANDAN E | 2009 | Materials Science and Engineering A2009，501，： | 1 |
| 9 | Effect of alloying elements to aluminium on the wettability of AI/SiC system 显示文摘 | CANDAN E | 2002 | Turkish J Eng Env Sci2002，26，： | 1 |
| 10 | Abrasive wear behaviour of AI-SiC composites produced by pressure infiltration technique显示文摘 | CANDAN E AHLATCI H CIMENOGLV H | 2001 | Wear2001，247，： | 1 |
| 11 | Biochemical effects of chlorpyrifos and dehamethrin on altered antioxidative defense mechanisms and lipid peroxidation in rat liver显示文摘 | TUZMEN N CANDAN N KAYA E | 2008 | Cell Biochem Funct2008，26，1： | 1 |
| 12 | Biochemical effects of chlor- pyrifos and delta methrin oll altered antioxidative defense mechanis ms and lipid peroxidation in rat liver 显示文摘 | N Tuz men N Candan E Kaya | 2008 | Cell Biochemistry and Function2008，26，1： | 1 |
| 13 | Biochemical effects of ehlorpyri- los and deltamethrin on alteres antioxidative defense mechanisms and lipid peroxidation in rat liver 显示文摘 | N Tuzmen N Candan E Kaya | 2008 | Cell Biochemistry and function2008，26，： | 1 |
| 14 | Microcotnputerised tomography evaluation of 10%carbamide peroxide applied to enamel显示文摘 | Neslihan E Dawid JW Candan E | 2005 | JDent2005，33，7： | 1 |
| 15 | Thirty-five percent carbamide peroxide application causes in vitro demine-raligation of enamel显示文摘 | Neslihan E Dawid JW Candan E | 2007 | Dent Mater2007，23，7： | 1 |
| 16 | Roles of climacteric ethylene in the development of chilling injury in plums显示文摘 | Candan A P GraeU J Larrigaudi&e C | 2008 | Postharvest Biology and Technology2008，47，1： | 1 |
| 17 | Biochemical effects of chlorpyrifos and deltamethrin on altered antioxidative defense mechanisms and lipid peroxidation in mt liver显示文摘 | TUZMEN N CANDAN N KAYA E | 2008 | Cell Biochem Funct2008，26，1： | 1 |
| 18 | Wear behaviour of Al(Al2O3p +SiCp) hybrid composites 显示文摘 | Ahlatci H Kocer T Candan E | 2006 | Tribology International2006，39，： | 1 |
| 19 | External morphology of the female genitalia of Lixusnordrnanni Hochhuth, 1847 (Coleoptera: Curcu?lionidae, Lixinae) , a scanning electron microscope study显示文摘 | Erbey M Candan S Kocak E | 2010 | Gazi UniversityJournal of Science2010，23，4： | 1 |
| 20 | Mechanical properties of Al-60 pct SiCp composites alloyed with Mg显示文摘 | Ahlatci H Candan E Cimenoglu H | 2004 | Metallurgical and Materials Transactions2004，35，7： | 1 |
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