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| 1 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 2 | N-methacryloyl-(L)-histidine methyl ester carrying porous magnetic beads for metal chelate adsorption of cytochromec显示文摘 | Akkaya B Uzun L Candan F | 2007 | Mater Sci Eng C2007，27，1： | 1 |
| 3 | N methacryloyl-(L) histidine methyl ester carrying porous magnetic beads for metal chelate adsorption of cytochrome c显示文摘 | Akkaya B Uzun L Candan F | 2007 | Materials Science and Engineering: C2007，27，1： | 1 |
| 4 | Relationship among chlorophyll carotenoid content, anfioxidant enzyme actlwtms and lipid pemxma- tion levels by Mg deficiency in the Mentha pulegium leaves显示文摘 | CANDAN N TARHAN L | 2003 | Plant Physiology and Biochemistry2003，41，： | 1 |
| 5 | Dialysate CA125 levels after 5 years on continuous peritoneal dialysis显示文摘 | Candan C Turhan P Sever L | | 0，，： | 1 |
| 6 | The correlation between antioxidant enzyme activities and lipid peroxidation levels in Mentha pulegium organs grown in Ca2 + , Mg3 + , Cu2 + , Zn2 + and Mn2 + stress conditions 显示文摘 | CANDAN N TARHAN L | 2003 | Plant Science2003，165，4： | 1 |
| 7 | The correlation between antioxidant en- zyme activities and lipid peroxidation levels in Mentha pulegi- um organs grown in Ca2 + , Mg2 + , Cu2 + , Zn2 + and Mn2 ~ stress conditions 显示文摘 | Candan N Tarhan L | 2003 | Plant Science2003，165，4： | 1 |
| 8 | Contribution of fabric characteristics and laundering to shrinkage of weft knitted fabric显示文摘 | Onal L Candan C | 2003 | Textile Research Journal2003，，3： | 1 |
| 9 | Assessment of tissue viabilityafter frostbite injury by technetium-99m-sestamibi scintigraphy in anexperimental rabbit model显示文摘 | Sarikaya I Aygit A C Candan L | 2000 | European Journal of Nuclear Medicine2000，27，1： | 1 |
| 10 | Blood volume monitoring to adjust dry weight in hypertensive epediatric hemodialysis patients显示文摘 | Candan C Sever L Civilibal M | 2009 | Pediatr Nephrol2009，24，3： | 1 |
| 11 | Contribution of fabric characteristics and laundering to shrinkage of weft knitted fabrics 显示文摘 | NAL L CANDAN C | 2003 | Textile Research Journal2003，73，3： | 1 |
| 12 | Relationship among chloro- phyll-carotenoid content, antioxidant enzyme ac- tivities and lipid peroxidation levels by Mg2+ de- ficiency in the Mentha puleum leaves 显示文摘 | Candan N Tarhan L | 2003 | Plant Physiology Biochemistry2003，41，： | 1 |
| 13 | Relationship among chlorophyll-carotenoid content,antioxidant enzyme activities and lipid peroxida-tion levels by Mg2+deficiency in the Mentha pulegium leaves显示文摘 | CANDAN N TARHAN L | 2003 | Plant Physiology and Biochemistry2003，41，1： | 1 |
| 14 | Relationship among chlorophyll carotenoid content,antioxidant enzyme activities and lipid peroxidation levels by Mg2+ deficiency in the Mentha pulegium leaves显示文摘 | Candan N Tarhan L | 2003 | Plant Physiology and Biochemistry2003，41，： | 1 |
| 15 | Similarity-based rankingand query processing in multimedia databases显示文摘 | Candan K S Li W S Priya M L | 2000 | Data &Knowledge Engineering2000，35，： | 1 |
| 16 | Relationship among chlorophyll-carotenoid content,antioxidant enzyme activities and lipid peroxidation levels by Mg2+ deficiency in the Mentha pulegium leaves显示文摘 | CANDAN N TARHAN L | 2003 | Plant Physiology Biochemistry2003，41，： | 1 |
| 17 | Relationship among chlorophyll-carotenoid content,antioxidant enzyme activities and lipid peroxidation levels by Mg2+ deficiency in the Mentha pulegium leaves显示文摘 | Candan N Tarhan L | 2003 | Plant Physiology and Biochemistry2003，41，： | 1 |
| 18 | Assessment of tissue vi-ability after frostbite injury by technetium-99m-sestamibi scintig-raphy in an experimental rabbit model 显示文摘 | Sarikaya I Aygit AC Candan L | 2000 | Eur J Nucl Med2000，27，1： | 1 |
| 19 | Blood volume monitoring to adjust dry weight in hypertensive pediatric hemodialysis patients显示文摘 | Candan C Sever L Civilibal M | 2009 | Pediatr Nephrol2009，24，3： | 1 |
| 20 | Relationship among chlorophyllcarotenoid content, antioxidant enzyme activities and lipid peroxidation levels by Mg deficiency in the Mentha pulegium leaves显示文摘 | CANDAN N TARHAN L | 2003 | Plant Physiology and Biochemistry2003，41，： | 1 |
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