4篇
您的检索式：作者名="Canhui Lan"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Help, hope and hype: ethical considerations of human microbiome research and applications显示文摘 | Yonghui Ma Hua Chen Canhui Lan Jianlin Ren | 2018 | Protein & Cell2018，9，5： | 6 |
| 2 | Seven facts and five initiatives for gut microbiome research显示文摘The gut microbiome has attracted increasing attention over the past 15 years.Along with the fast-growing body of research literature and media reports,the public's opinions on the gut microbiome have begun to appear polarized.Some believe that the gut microbiome is at the core of human health and is related to every single disease.To the opposite,some people question the scientific basis of gut microbiome studies and criticize that many of them are farfetched;there is even a joke spreading in the biomedical research field—'keeping gut microbiome in mind,no mechanism is hard to find'. | Danyi Li Chunhui Gao Faming Zhang Ruifu Yang Canhui Lan Yonghui Ma Jun Wang | 2020 | Protein & Cell2020，11，6： | 1 |
| 3 | Structural characteristics and biological functions of the HIV-1 gp120 V3 region显示文摘Recent studies demonstrate that the V3 loop of HIV-1 gp120 plays an important role in the attachment of HIV-1 to the target cells. Several amino acids in this domain are involved in the interaction of gp120 with the co-receptors. The V3 loop elicits one of the earliest antiviral antibody responses in HIV-1 infection and has been identified as the principal neutralizing determinant (PND). A subset of antibodies to V3 loop show a broad range of neutralizing activity. Unfortunately, this loop undergoes broad mutation and is one of the hypervariable regions. Mutations of some amino acids in this PND could affect syncytium formation, virus infectivity and neutralization. Knowing the structural characteristics and biological functions of the V3 region could help us to understand mechanism of HIV infection and to develop new strategy against HIV-1. In this review, the structural characteristics, variation and biological functions of the V3 loop as well as immunological responses to the V3 loop are discussed. | TIAN Haijun, LAN Canhui, JIANG Shibo2 and CHEN Yinghua(1. Laboratory of Immunology, Department of Biological Science and Biotechnology, Tsinghua University Protein Science Laboratory of the Ministry of Education, Beijing 100084, China 2. LindsleyF. Kimball Research Institute, New York Blood Center, USA) | 2002 | Progress in Natural Science:Materials International2002，12，11： | 0 |
| 4 | Evidence for existence of a close association between CD14 and CXCR4 on monocytic cell line U937显示文摘单核白血球上的 HIV-1 coreceptors (CXCR4 和 CCR5 ) 的表面表示能被房间的 CD14,和危险性的 ligand 调整到 HIV-1 然后被改变。我们的以前的学习发现对 CD14 的那单音的同种细胞的抗体能戏剧性地禁止药物治疗 CXCR4 的趋化性和房间房间熔化。把研究基于这些,我们在结合 lineFITC 的 anti-CD14 monocolnal 抗体(mAb ) 12G5 强烈禁止了的 monocytic 房间上探索了在 CD14 和 CXCR4 之间的潜在的关系结合 FITC 的 anti-CD14 有约束力单音的同种细胞的抗体(TUK4 和 UCHM1 ) 到 U937,当另一 CX-CR4-specific mAb B-R24 没在这绑定上显示出任何效果时。在另一方面,二 anti-CD14 单音的同种细胞的抗体(TK4 和 UCH-M1 ) 显然禁止了结合 PE 的 anti-CXCR4 mAb 12G5 的绑定到 U937 但是没禁止 mAb 12G5 的绑定到 CXCR4-transfected 3T3 房间(3T3。T4, CXCR4 ) ,它显示由 CD14 特定的 mAbs 堵住对 CXCR4 有约束力的 mAb 12G5 不涉及可能性那 CD14 特定的 mAbs 直接绑在 CXCR4。这些结果在 monocytic 房间线 U937 上建议了在 CD14 和 CXCR4 之间的一个靠近的协会的存在。 | Yang Hengwen Lan Canhui Chen Yinghua | 2007 | Progress in Natural Science:Materials International2007，17，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员