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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Candidemia at a tertiary-care hospital: epidemiology, treatment, clinical outcome and risk factors for death 显示文摘 | Viudes A Peman J Canton E | 2002 | Eur J Clin Microbiol Infect Dis2002，21，： | 1 |
| 3 | Influence of particle size and crystal orientation on the electrochemical behavior of carbon-coated LiFePO4 显示文摘 | FERRAR1 S LAVALL R L CAPAONI D QUARTARONE E MAGISTRIS A MUSTARELLI P CANTON P | 2010 | J Phys Chem C2010，114，12： | 1 |
| 4 | Long -term exposure of European flounder (Platichthys flesus) to the flame-retardants tetrabromobisphenol A (TBBPA) and hexabromocyclododecane (HBCD) 显示文摘 | Kuiper R V Canton R F Leonards P E G | 2007 | Ecotoxicol Environ Saf2007，67，3： | 1 |
| 5 | Antifungal drug resis- tancemechanisms 显示文摘 | Peman J Canton E Espinel-Ingroff A | 2009 | Expert Rev Anti hffect Ther2009，7，4： | 1 |
| 6 | Paternal investment and reproductive success in the California mouse, Peromyscus califooricus 显示文摘 | Canton D Brown R E | 1996 | Anim Behav1996，54，： | 1 |
| 7 | In vitro activity of sparfloxacin compared with those of five other quinolones显示文摘 | Canton E Peman J Jimenez MT | 1992 | Antimicrob Agents Chemother1992，36，： | 1 |
| 8 | Integron content of ex- tended-spectrum- 13-1actamase-producing Escherichia coli strains over 12 years in a single hospital in Madrid,Spain显示文摘 | Machado E Canton R Baquero F | 2005 | Antimicrob Agents Chemother2005，49，5： | 1 |
| 9 | Thermal comfort in forested urban canyons of low building density: an assessment for the city of Mendoza, Argentina 显示文摘 | CORREA E RUIZ M A CANTON A | 2012 | Building and Environment2012，58，： | 1 |
| 10 | In vitro postanibiotic effect of sparfloxacin and ciprofloxacin against Pseudomonas aeruginosa and Enterococcus faecalis显示文摘 | Paster A Peman J Canton E | 1994 | J Antimicrob Chemother1994，34，： | 1 |
| 11 | Growth and the cycle: creative de- struct/on versus entrenchment 显示文摘 | Canton E Uhlig H | 1999 | Journal of Econom- ics1999，69，3： | 1 |
| 12 | Vested Interests, Population Ageing and Technology Adoption 显示文摘 | Canton E J F Groot H L F Nahuis R | 2002 | European Journal of Political Economy2002，18，4： | 1 |
| 13 | Scapular dyskine- sis and SICK scapula syndrome following surgical treat- ment of type III acute acromioclavicular dislocations显示文摘 | Murena L Canton G Vulcano E | 2013 | Knee Surg Sports Traumatol Arthrosc2013，21，5： | 1 |
| 14 | Study on the toxicity of sodium bromide to different freshwater organisms显示文摘 | Canton J H Wester P W Mathijssen-Spiekman E A | 1983 | Food Chem Toxicol1983，21，4： | 1 |
| 15 | Periodontral regeneration via selective cell repopulationm显示文摘 | Canton J G Defuria E L Polson A M | 1987 | J Periodontol1987，8，8： | 1 |
| 16 | In vitro postantibiotic effect of sparfloxacin and Enterococcus feacalis显示文摘 | Pastor A Peman J Canton E | 1994 | J Antimicrob Chemother1994，34，5： | 1 |
| 17 | Changes in the epidemi- ology of fungaemia and fluconazole susceptibility of blood iso- lates during the last 10 years in Spain results from the FUN- GEMYCA study显示文摘 | Peman J Canton E Minana J J | 2011 | Rev Iberoam Micol2011，28，： | 1 |
| 18 | In vitro activity of linezolid in combination with doxycycline, fosfomycin, levofloxacin, rifampicin and vancomycin against methicillin- susceptible Staphylococcus aureus 显示文摘 | Sahuquillo Arce JM Colombo Gainza E Gil Brusola A Ortiz Estevez R Canton E Gobemado M | 2006 | Rev Esp Quimioter2006，19，3： | 1 |
| 19 | Expression analysis of a cytosolic glutamine synthetase gene in cotyledons of Scots pine seedlings:Developmental,light-dark regulation and spatial distribution of specific transcripts显示文摘 | Canton F R Suarez M F Jose E M | 1999 | Plant Molecular Biology1999，40，： | 1 |
| 20 | In vitro activity of sparfloxacin compared with those of five other quinolones 显示文摘 | Canton E Peman J Jimenez M T | 1992 | Antimicrob Agents Chemother1992，36，3： | 1 |
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