|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 2 | Familial nontoxic multinodular thyroid goiter locus maps to chromosome 14q but does not account for familial nonmedullary thyroid cancer显示文摘 | Bignell GR Canzian F Shayeghi M | 1997 | Am J Hum G enet1997，，61： | 1 |
| 3 | Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study 显示文摘 | Hung R J Brennan P Canzian F | 2005 | J Natl Cancer Inst2005，97，8： | 1 |
| 4 | Depression and anxiety in parent versus spouse caregivers of adult patients with traumatic brain injury: a systematic review显示文摘 | Ennis N Rosenbloom BN Canzian S | 2013 | Neuropsychol Rehabil2013，23，1： | 1 |
| 5 | Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin like growth factor - 1 metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium 显示文摘 | Canzian F Cox DG Setiawan VW | 2010 | Hum Mol Genet2010，19，19： | 1 |
| 6 | Polymorphisms in Genes Related to Bacterial Lipopolysaccharide/Peptidoglycan Signaling and Gastric Precancerous Lesions in a Population at High Risk for Gastric Cancer显示文摘 | Ikuko Kato Federico Canzian Martyn Plummer Silvia Franceschi Leen-Jan Doorn Jorge Vivas Gladys Lopez Yanhui Lu Lydie Gioia-Patricola Richard K. Severson Ann G. Schwartz Nubia Mu?oz | 2007 | Digestive Diseases and Sciences2007，，1： | 1 |
| 7 | Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela显示文摘 | Ikuko Kato Federico Canzian Silvia Franceschi Martyn Plummer Leen-Jan Doorn Yanhui Lu Lydie Gioia-Patricola Jorge Vivas Gladys Lopez Richard K. Severson Ann G. Schwartz Nubia Mu?oz | 2006 | Cancer Causes & Control2006，，9： | 1 |
| 8 | Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract显示文摘 | Daniele Campa Mia Hashibe David Zaridze Neonila Szeszenia-Dabrowska Ioan Nicolae Mates Vladimir Janout Ivana Holcatova Eleonóra Fabiánová Valérie Gaborieau Rayjean J. Hung Paolo Boffetta Paul Brennan Federico Canzian | 2007 | Cancer Causes & Control2007，，4： | 1 |
| 9 | Patient satisfaction and documentation of pain assessments and management after implementing the adult nonverbal pain scale显示文摘 | Topolovec-Vranic J Canzian S Innis J | | 0，，： | 1 |
| 10 | Poly-morphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study显示文摘 | Canzian F McKay JD Cleveland RJ | 2006 | Br J Cancer2006，94，2： | 1 |
| 11 | Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study显示文摘 | Hung RJ Brennan P Canzian F | 2005 | J Natl Cancer Inst2005，97，： | 1 |
| 12 | Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter-study显示文摘 | Hung RJ Brennau P Canzian F | 2005 | J Nat Cancer Inst2005，97，8： | 1 |
| 13 | Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer 显示文摘 | Kato I Canzian F Plummer M | 2007 | Dig Dis Sci2007，52，1： | 1 |
| 14 | Polymorphisms of genes coding for insulin - like growth factor 1 and its major binding proteins, circulating levels of IGF - I and IGFBP- 3 and breast cancer risk: results from the EPIC study显示文摘 | Canzian F McKay JD Cleveland R J | 2006 | Br J Cancer2006，94，2： | 1 |
| 15 | Familial nontoxic multinodular thyroid goiter locus maps to chromosome 14q but does not account for familial nonmedullary thyroid cancer显示文摘 | Bignell GR Canzian F Shayeghi M | 1997 | Am J Hum Genet1997，61，5： | 1 |
| 16 | DNA repair and cell cycle control genes and the risk of young-onset lung cancer显示文摘 | Stefano Landi Federica Gemignani Federico Canzian | 2006 | Cancer Res2006，66，11： | 1 |
| 17 | Familial nontoxic multinodular thyroid goiter locus maps to chromosome 14q but does not account for familial nonmedullary thyroid cancer 显示文摘 | Bignell GR Canzian F Shayeghi M | 1997 | Am J Hum Genet1997，61，5： | 1 |
| 18 | Patient satisfaction and documentation of pain assessments and management after implemen- ting the adult nonverbal pain scale显示文摘 | Topolovec Vranic J Canzian S Innis J | 2010 | Am J Crit Care2010，19，4： | 1 |
| 19 | No association between progesterone receptor gene +331G/A polymorphism and endometrial cancer 显示文摘 | Dossus L Canzian F Kaaks R | 2006 | Cancer Epidemiol Biomarkers Prey2006，15，7： | 1 |
| 20 | PTGS2 and IL6 genetic variation and risk of breast and prostate cancer:results from the Breast and Prostate Cancer Cohort Consortium (BPC3)显示文摘 | Dossus L Kaaks R Canzian F | 2010 | Carcinogenesis2010，31，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员