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| 1 | SOX2 in cancer stemness: tumor malignancy and therapeutic potentials显示文摘Cancer stem cells(CSCs),a minor subpopulation of tumor bulks with self-renewal and seeding capacity to generate new tumors,posit a significant challenge to develop effective and long-lasting anti-cancer therapies.The emergence of drug resistance appears upon failure of chemo-/radiation therapy to eradicate the CSCs,thereby leading to CSC-mediated clinical relapse.Accumulating evidence suggests that transcription factor SOX2,a master regulator of embryonic and induced pluripotent stem cells,drives cancer stemness,fuels tumor initiation,and contributes to tumor aggressiveness through major drug resistance mechanisms like epithelial-to-mesenchymal transition,ATP-binding cassette drug transporters,anti-apoptotic and/or pro-survival signaling,lineage plasticity,and evasion of immune surveillance.Gaining a better insight and comprehensive interrogation into the mechanistic basis of SOX2-mediated generation of CSCs and treatment failure might therefore lead to new therapeutic targets involving CSC-specific anti-cancer strategies. | Mahfuz Al Mamun Kaiissar Mannoor Jun Cao Firdausi Qadri Xiaoyuan Song | 2020 | Journal of Molecular Cell Biology2020，12，2： | 3 |
| 2 | Fractional-Order Model of the Disease Psoriasis:A Control Based Mathematical Approach显示文摘Autoimmune diseases are generated through irregular immune response of the human body.Psoriasis is one type of autoimmune chronic skin diseases that is differentiated by T-Cells mediated hyper-proliferation of epidermal Keratinocytes.Dendritic Cells and CD8^+T-Cells have a significant role for the occurrence of this disease.In this paper,the authors have developed a mathematical model of Psoriasis involving CD4^+T-Cells,Dendritic Cells,CD8^+T-Cells and Keratinocyte cell populations using the fractional differential equations with the effect of Cytokine release to observe the impact of memory on the cell-biological system.Using fractional calculus,the authors try to explore the suppressed memory,associated with the cell-biological system and to locate the position of Keratinocyte cell population as fractional derivative possess non-local property.Thus,the dynamics of Psoriasis can be predicted in a better way using fractional differential equations rather than its corresponding integer order model.Finally,the authors introduce drug into the system to obstruct the interaction between CD4^+T-Cells and Keratinocytes to restrict the disease Psoriasis.The authors derive the Euler-Lagrange conditions for the optimality of the drug induced system.Numerical simulations are made through Matlab by developing iterative schemes. | CAO Xianbing DATTA Abhirup AL BASIR Fahad ROY Priti Kumar | 2016 | Journal of Systems Science & Complexity2016，29，6： | 3 |
| 3 | Determination of pore size distribution and adsorption of methane and CCl4 on activated carbon by molecular simulation显示文摘 | CAO D WANG W SHEN Z et al | 2002 | Carbon NY2002，40，13： | 1 |
| 4 | Nonlinear model predictive control for the ALSTOM gasifier显示文摘 | Seyab R K Al Cao Y | 2006 | Journal of Process Control2006，16，8： | 1 |
| 5 | Th17 cells facilitate the humoral immune response in patients with acute viral myocarditis显示文摘 | Yuan J Cao AL Yu M | | Journal of Clinical Immunology0，，： | 1 |
| 6 | Ras/ERK signaling pathway is involved in curcumin-induced cell cycle arrest and apoptosis in human gastric carcinoma AGS cells 显示文摘 | Cao AL Tang QF Zhou WC | 2014 | J Asian Nat Prod Res2014，10，： | 1 |
| 7 | The knoevenagel condensa- tion of aromatic aldehydes with malononitrile of ethyl cyano- acetate in the presence of CTMAB in water显示文摘 | Wang S Ben Z Cao W ct al | 2001 | Synth Com- mun2001，31，5： | 1 |
| 8 | Association of specific vacA types with cytotoxin production and peptic ulceration显示文摘 | Atherton JC Cao P Peek RM Jr et aL Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori | 1995 | J Biol Chem1995，270，17： | 1 |
| 9 | Airway hyperresponsiveness induced by repeated esophageal infusion of HCl in guinea pigs显示文摘 | Cheng YM Cao AL Zheng JP | 2014 | Am J Respir Cell Mol Biol2014，51，5： | 1 |
| 10 | Towards intelligent contention- based geographic forwarding in wireless sensor networks 显示文摘 | Cheng L Cao J Chen C F et aL | 2011 | IET Communications2011，5，12： | 1 |
| 11 | Effects of dietary, fish oil on learning function and apoptosis of hippoeampal pyramidal neurons in streptnzoto- cin- diabetie rats显示文摘 | Zhao CH Liu HQ Cao R el al | 2012 | Brain Res2012，，： | 1 |
| 12 | New Application of a Known 2-quinolinecarboxaldehyde Schiff Base as a Colorimetric and Fluorescent ' Off-On' Probe for Copper (Ⅱ) 显示文摘 | Tang L J Guo J J Cao Y H et Molecule: Rhodamine B 8-hydroxy- al | 2012 | Journal of Fluorescence2012，22，6： | 1 |
| 13 | Estrogen and progestin regulate metastasis through the PI3 K/AKT pathway in human ovarian cancer显示文摘 | Hua K Feng W Cao Q et al | 2008 | Int J Oncol2008，33，5： | 1 |
| 14 | MHCⅡis required for alpha-synuclein-induced activation of microglia,CD4 T cell proliferation,and dopaminergic neurodegeneration显示文摘 | Harms AS Cao S Rowse AL | 2013 | J Neurosci2013，33，23： | 1 |
| 15 | CD40 ligand expressed in the immunogenicity of the GP3 and GP5 of porcine reproductive and respiratory syndrome virus in swine显示文摘 | Cao J Wang X Du Y et adenovirus can improve al | 2010 | Vaccine2010，28，47： | 1 |
| 16 | Blood-based EF-PCR assays of MN/CA9 or PSMA: clinical application in renal cancer patients显示文摘 | de la Taille A Katz A Cao Y et al | 2000 | Urology2000，56，3： | 1 |
| 17 | Thl7 Cells facilitate the hu- moral immune response in patients with acute viral myocardi- tis 显示文摘 | Yuan J Cao AL Yu M | 2010 | J Clin Immunol2010，30，2： | 1 |
| 18 | Investigation of monolithic quesi-planar ring lasers显示文摘 | Zang Erjun Cao Hongjun Zhao Kun et al | 1998 | SPIE1998，3549，： | 1 |
| 19 | Histone deacetylase inhihitor,downregulation of bcl-xl gene expression leads to apoptoic cell death in mesothelioma显示文摘 | Cao XX Mohuiddin I Ece F et al | 2001 | Am J Respir Cell Mol Biol2001，25，5： | 1 |
| 20 | A quinary layer transition metaloxide of NaNi1/4 Co1/4 Fe,/4 Mn1/S Ti}/S 02 as a high-rate-capabilityand long-cycle-life cathode material for rechargeable sodium ionbatteries 显示文摘 | Yue J L Yin W W Cao M al | 2015 | Chemical Communications2015，51，15： | 1 |
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