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| 1 | Mixed secondary chromatin structure revealed by modeling radiation-induced DNA fragment length distribution显示文摘Spatial chromatin structure plays fundamental roles in many vital biological processes including DNA replication, transcription,damage and repair. However, the current understanding of the secondary structure of chromatin formed by local nucleosomenucleosome interactions remains controversial, especially for the existence and conformation of 30 nm structure. Since chromatin structure influences the fragment length distribution(FLD) of ionizing radiation-induced DNA strand breaks, a 3D chromatin model fitting FLD patterns can help to distinguish different models of chromatin structure. Here, we developed a novel '30-C' model combining 30 nm chromatin structure models with Hi-C data, which measured the spatial contact frequency between different loci in the genome. We first reconstructed the 3D coordinates of the 25 kb bins from Hi-C heatmaps. Within the25 kb bins, lower level chromatin structures supported by recent studies were filled. Simulated FLD patterns based on the 30-C model were compared to published FLD patterns induced by heavy ion radiation to validate the models. Importantly, the 30-C model predicted that the most probable chromatin fiber structure for human interphase fibroblasts in vivo was 45% zig-zag 30 nm fibers and 55% 10 nm fibers. | Wenzong Ma Chenyang Gu Lin Ma Caoqi Fan Chao Zhang Yujie Sun Cheng Li Gen Yang | 2020 | Science China(Life Sciences)2020，63，6： | 1 |
| 2 | Anew ferrocene-anthracene dyad bearing amide and triazolium donors for dual-signaling sensing to anions显示文摘 | CaoQY HanYM YaoPS etal | 2014 | Tetrahedron Lett2014，，： | 1 |
| 3 | 显示文摘 | CaoQi(曹琦) GaoPeng(高鹏) ZhongYi(钟毅)etal | 2011 | 材料导报B2011，25，： | 1 |
| 4 | Comparative transcriptome analysis reveals molecular adaptations underlying distinct immunity and inverted resting posture in bats显示文摘Understanding how natural selection shapes unique traits in mammals is a central topic in evolutionary biology.The mammalian order Chiroptera(bats)is attractive for biologists as well as the general public due to their specific traits of extraordinary immunity and inverted resting posture.However,genomic resources for bats that occupy key phylogenetic positions are not sufficient,which hinders comprehensive investigation of the molecular mechanisms underpinning the origin of specific traits in bats.Here,we sequenced the transcriptomes of 5 bats that are phylo-genetically divergent and occupy key positions in the phylogenetic tree of bats.In combination with the available genomes of 19 bats and 21 other mammals,we built a database consisting of 10918 one-to-one ortholog genes and reconstructed phylogenetic relationships of these mammals.We found that genes related to immunity,bone remodeling,and cardiovascular system are targets of natural selection along the ancestral branch of bats.Further analyses revealed that the T cell receptor signaling pathway involved in immune adaptation is specifically enriched in bats.Moreover,molecular adaptations of bone remodeling,cardiovascular system,and balance sensing may help to explain the reverted resting posture in bats.Our study provides valuable transcriptome resources,enabling us to tentatively identify genetic changes associated with bat-specific traits.This work is among thefirst to advance our understanding of the molecular underpinnings of inverted resting posture in bats,which could provide insight into healthcare applications such as hypertension in humans. | Jinwei WU Libiao ZHANG Chao SHEN Simon Yung Wa SIN Caoqi LEI Huabin ZHAO | 2023 | Integrative Zoology2023，18，3： | 0 |
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