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| 1 | Hepatic echinococcosis:Clinical and therapeutic aspects显示文摘Echinococcosis or hydatid disease(HD)is a zoonosis caused by the larval stages of taeniid cestodes belonging to the genus Echinococcus.Hepatic echinococcosis is a life-threatening disease,mainly differentiated into alveolar and cystic forms,associated with Echinoccus multilocularis(E.multilocularis)and Echinococcus granulosus(E.granulosus)infection,respectively.Cystic echinococcosis(CE)has a worldwide distribution,while hepatic alveolar echinococcosis(AE)is endemic in the Northern hemisphere,including North America and several Asian and European countries,like France,Germany and Austria.E.granulosus young cysts are spherical,unilocular vesicles,consisting of an internal germinal layer and an outer acellular layer.Cyst expan-sion is associated with a host immune reaction and the subsequent development of a fibrous layer,called the pericyst;old cysts typically present internal septations and daughter cysts.E.multilocularis has a tumorlike,infiltrative behavior,which is responsible for tissue destruction and finally for liver failure.The liver is the main site of HD involvement,for both alveolar and cystic hydatidosis.HD is usually asymptomatic for a long period of time,because cyst growth is commonly slow;the most frequent symptoms are fatigue and abdominal pain.Patients may also present jaundice,hepatomegaly or anaphylaxis,due to cyst leakage or rupture.HD diagnosis is usually accomplished with the combined use of ultrasonography and immunodiagnosis;furthermore,the improvement of surgical techniques,the introduction of minimally invasive treatments[such as puncture,aspiration,injection,re-aspiration(PAIR)]and more effective drugs(such as benzoimidazoles)have deeply changed life expectancy and quality of life of patients with HD.The aim of this article is to provide an up-todate review of biological,diagnostic,clinical and therapeutic aspects of hepatic echinococcosis. | Giuseppe Nunnari Marilia R Pinzone Salvatore Gruttadauria Benedetto M Celesia Giordano Madeddu Giulia Malaguarnera Piero Pavone Alessandro Cappellani Bruno Cacopardo | 2012 | World Journal of Gastroenterology2012，18，13： | 72 |
| 2 | Incidental gallbladder cancer during laparoscopic cholecystectomy:Managing an unexpected finding显示文摘AIM:To evaluate the impact of incidental gallbladder cancer on surgical experience.METHODS:Between 1998 and 2008 all cases of cholecystectomy at two divisions of general surgery,one university based and one at a public hospital,were retrospectively reviewed.Gallbladder pathology was diagnosed by history,physical examination,and laboratory and imaging studies [ultrasonography and computed tomography(CT)].Patients with gallbladder cancer(GBC) were further analyzed for demographic data,and type of operation,surgical morbidity and mortality,histopathological classification,and survival.Incidental GBC was compared with suspected or preoperatively diagnosed GBC.The primary endpoint was diseasefree survival(DFS).The secondary endpoint was the difference in DFS between patients previously treated with laparoscopic cholecystectomy and those who had oncological resection as first intervention.RESULTS:Nineteen patients(11 women and eight men) were found to have GBC.The male to female ratio was 1:1.4 and the mean age was 68 years(range:45-82 years).Preoperative diagnosis was made in 10 cases,and eight were diagnosed postoperatively.One was suspected intraoperatively and confirmed by frozen sections.The ratio between incidental and nonincidental cases was 9/19.The tumor node metastasis stage was:pTis(1),pT1a(2),pT1b(4),pT2(6),pT3(4),pT4(2);five cases with stageⅠa(T1 a-b);two with stageⅠb(T2 N0);one with stage Ⅱa(T3 N0);six with stage Ⅱb(T1-T3 N1);two with stage Ⅲ(T4 Nx Nx);and one with stage Ⅳ(Tx Nx Mx).Eighty-eight percent of the incidental cases were discovered at an early stage(≤Ⅱ).Preoperative diagnosis of the 19 patients with GBC was:GBC with liver invasion diagnosed by preoperative CT(nine cases),gallbladder abscess perforated into hepatic parenchyma and involving the transversal mesocolon and hepatic hilum(one case),porcelain gallbladder(one case),gallbladder adenoma(one case),and chronic cholelithiasis(eight cases).Every case,except one,with a T1b or more advanced invasion underwent Ⅳb + Ⅴ wedge liver resection and pericholedochic/hepatoduodenal lymphadenectomy.One patient with stage T1b GBC refused further surgery.Cases with Tis and T1a involvement were treated with cholecystectomy alone.One incidental case was diagnosed by intraoperative frozen section and treated with cholecystectomy alone.Six of the nine patients with incidental diagnosis reached 5-year DFS.One patient reached 38 mo survival despite a port-site recurrence 2 years after original surgery.Cases with non incidental diagnosis were more locally advanced and only two patients experienced 5-year DFS.CONCLUSION:Laparoscopic cholecystectomy does not affect survival if implemented properly.Reoperation should have two objectives:R0 resection and clearance of the lymph nodes. | Andrea Cavallaro Gaetano Piccolo Vincenzo Panebianco Emanuele Lo Menzo Massimiliano Berretta Antonio Zanghì Maria Di Vita Alessandro Cappellani | 2012 | World Journal of Gastroenterology2012，18，30： | 33 |
| 3 | Use of biological meshes for abdominal wall reconstruction in highly contaminated fields显示文摘Abdominal wall defects and incisional hernias represent a challenging problem. In particular, when a synthetic mesh is applied to contaminated wounds, its removal is required in 50%-90% of cases. Biosynthetic meshes are the newest tool available to surgeons and they could have a role in ventral hernia repair in a potential-ly contaminated field. We describe the use of a sheet of bovine pericardium graft in the reconstruction of abdominal wall defect in two patients. Bovine pericardium graft was placed in the retrorectus space and secured to the anterior abdominal wall using polypropylene sutures in a tension-free manner. We experienced no evidence of recurrence at 4 and 5 years follow-up. | Andrea Cavallaro Emanuele Lo Menzo Maria Di Vita Antonio Zanghì Vincenzo Cavallaro Pier Francesco Veroux Alessandro Cappellani | 2010 | World Journal of Gastroenterology2010，16，15： | 9 |
| 4 | Intrahepatic Cholangiocarcinoma: Prognostic Factors After Surgical Resection显示文摘 | Alfredo Guglielmi Andrea Ruzzenente Tommaso Campagnaro Silvia Pachera Alessandro Valdegamberi Paola Nicoli Alessandro Cappellani Giulio Malfermoni Calogero Iacono | 2009 | World Journal of Surgery2009，，6： | 3 |
| 5 | Giant gastrointestinal stromal tumor(GIST) of the stomach cause of high bowel obstruction: surgical management 显示文摘 | Cappellani A Piccolo G Cardi F | 2013 | World J Surg Onco12013，11，： | 1 |
| 6 | Severe bradycardia during scalp nerve block in patient undergoing awake craniotomy 显示文摘 | Chowdhury T Baron K Cappellani RB | 2013 | Saudi J Anaesth2013，7，3： | 1 |
| 7 | The recurrent goiter:prevention and management显示文摘 | Cappellani A Di Vita M Zanghi A | 2008 | Ann ltal Chir2008，79，4： | 1 |
| 8 | Early brain injury and subarachnoid hemorrhage:Where are we at present?显示文摘 | Chowdhury T Dash H H Cappellani R B | 2013 | SaudiJ Anaesth2013，7，2： | 1 |
| 9 | Non-parasitic cysts of the liver:laparoscopic treatment and long-term results显示文摘 | Cappellani A Zangh A Vita M Di | 2002 | Ann Ital Chir2002，73，1： | 1 |
| 10 | Clinical and biologi-cal markers in gastric cancer:update and perspectives显示文摘 | Cappellani A Zanghi A Di Vita M | 2010 | FrontBiosci2010，2，： | 1 |
| 11 | Comparison ofjunctionless and conventional trigate transistors with lg down to 26 nm 显示文摘 | RIOS R CAPPELLANI A ARMSTRONG M | 2011 | IEEE Electron Device Letters2011，32，9： | 1 |
| 12 | Adjuvant radiotherapy on older and oldest breast cancer patients after conservative surgery: A retrospective analysis显示文摘 | Francesco Fiorica Massimiliano Berretta Stefano Ursino Rossella Fisichella Arben Lleshi Gerlando Fiorica Antonio Stefanelli Giampaolo Zini Umberto Tirelli Antonio Zanghi Alessandro Cappellani Salvatore Berretta Francesco Cartei | 2011 | Archives of Gerontology and Geriatrics2011，，2： | 1 |
| 13 | From cisdichloride complexes to dihydride complexes of the iron group metals via two successive 2-dihydrogen intermediates显示文摘 | Cappellani E P Maltby P A Steele M R | 1989 | Inorg Chem1989，28，25： | 1 |
| 14 | Intrahepatic Cholangiocarcinoma: Prognostic Factors After Surgical Resection显示文摘 | Alfredo Guglielmi Andrea Ruzzenente Tommaso Campagnaro Silvia Pachera Alessandro Valdegamberi Paola Nicoli Alessandro Cappellani Giulio Malfermoni Calogero Iacono | 2009 | World Journal of Surgery2009，，6： | 1 |
| 15 | The recurrent goiter:prevention and management 显示文摘 | Cappellani A Di Vita M Zanghi A | 2008 | Ann Ital Chir2008，79，4： | 1 |
| 16 | FOLFOX4 in the treatment of metastatic colorectal cancer in elderly patients: a prospective study显示文摘 | Berretta M Cappellani A Fiorica F | 2011 | Arch Gerontol Geriatr2011，52，1： | 1 |
| 17 | Perioperative variables contributing to the rupture of intracranial aneurysm:an update显示文摘 | Chowdhury T Cappellani RB Sandu N | 2013 | Scientific World Journal2013，2013，39： | 1 |
| 18 | Retrospective survey on laparoscopic cholecystectomy in the cirrhotic patient显示文摘 | Cappellani A Cacopardo B Zanghi A | 2008 | Eur Rev Med Pharmacol Sci2008，12，4： | 1 |
| 19 | Antibioticsusceptibility profiles of uncommon bacterial speciescausing severe infections in Italy 显示文摘 | Nicolosi D NicolosiVM Cappellani A et a/ | 2009 | J Chemother2009，21，3： | 1 |
| 20 | FOLFOX 4 in the treantment of metastatic colorectal cancer in elderly patients: a prospective study 显示文摘 | Berretta M Cappellani A Firiea F | 2011 | Arch Gerontol Gerimr2011，52，1： | 1 |
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