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| 1 | Ca^(2+):a versatile master key for intracellular signaling cascades显示文摘Ca2+is one of the most ancient and versatile intracellular messengers in both animal and plant systems.Ca2+interacts with a huge array of signaling proteins,and coordinates the integration of non-signaling proteins into cellular communication systems.In doing so,Ca2+plays crucial roles | Shi-Qiang WANG Michael XZHU Ernesto CARAFOLI | 2011 | Science China(Life Sciences)2011，54，8： | 3 |
| 2 | The plasma membrane calcium pump in the hearing process:physiology and pathology显示文摘Mammalian cells express four different plasma membrane Ca2+ ATPases.Two of them(PMCA1 and PMCA4) are expressed ubiquitously,and are considered housekeeping isoforms.Two(PMCA2 and PMCA4) have tissue restricted distribution.They are abundantly expressed in the brain and in nervous tissue-derived cell types.The primary transcripts of all PMCAs undergo alternative splicing,generating a large number of additional isoforms.Splicing occurs at site A,in the N-terminal moiety of the pump,and at site C,within the C-terminal calmodulin binding domain:The pumps are canonical targets of calmodulin stimu-lation.The site C insertion leads to a truncation of the pump about 50 residues short of the original C-terminal.One of the pumps(PMCA2) has special properties:It displays high activity even in the absence of the natural activator calmodulin,and has a particularly complex pattern of alternative splicing at both sites A and C.A variant of the PMCA2 pump containing an insert at site A and truncated C-terminally is the resident isoform of the pump in the stereocilia of hair cells of the inner ear.It exports Ca2+to the endolymph that bathes the stereocilia less efficiently than the full length,non-inserted PMCA2 pump.The proper functioning of hair cells demands the precise maintenance of the Ca2+balance between hair cells and the endolymph. Disturbances in the balance affect the process of mechano-electrical transduction,which depends on the ability of the stereo-ciliar bundle to deflect in response to sound waves.The tip links that organize the bundle are formed by the Ca2+binding pro-tein cadherin 23 and by protocadherin 15:Disturbances of the Ca2+binding by cadherin 23 and/or of the ability of the PMCA2 variant of the stereocilia to export Ca2+to the endolymph generate hearing loss phenotypes.Such phenotypes have now been described in mice and humans.In some cases they are linked to mutations of both cadherin 23 and the PMCA2 pump,but in other cases they may be generated by mutations of particular severity in only one of the two proteins.The PMCA2 defect that leads to deafness has now been analyzed molecularly:It affects the long range,unstimulated ability of PMCA2 to export Ca2+. | Ernesto CARAFOLI | 2011 | Science China(Life Sciences)2011，54，8： | 3 |
| 3 | Ca2+-activated neutral protease is active in the erythrocyte membrane in its non-autolyzed 80 kDa form显示文摘 | Molinari M Carafoli E | 1994 | J Biol Chem1994，269，27： | 1 |
| 4 | Collagen recognition and transmembrane signalling by discoidin domain receptors 显示文摘 | Carafoli F Hohenester E | 2013 | Biochim Biophys Acta2013，1834，10： | 1 |
| 5 | Calpain:a protease in search of a function Biochem Biophy Res显示文摘 | Carafoli E Molinari M | 2000 | Commoun2000，247，： | 1 |
| 6 | A historical review of cellular calcium handling, with emphasis on mitochondria显示文摘 | N.-E. L. Saris E. Carafoli | 2005 | Biochemistry (Moscow)2005，，2： | 1 |
| 7 | Calcium signaling: A tale for all seasons显示文摘 | Carafoli E | 2002 | Proc Nat/ Acad Sci USA2002，99，3： | 1 |
| 8 | Collagen recognition and transmembrane signalling by discoidin domain receptors 显示文摘 | CARAFOLI F HOHENESTER E | 2013 | Biochim Biophys Acta2013，1834，10： | 1 |
| 9 | The homeostasis of calcium in heart cells显示文摘 | Carafoli E | 1985 | J Molcell Cardiol1985，17，3： | 1 |
| 10 | Calcium signaling: a tale for all seasons显示文摘 | Carafoli E | 2002 | Proc Natl Acad Sci USA2002，99，： | 1 |
| 11 | Cloning and expression of isoform 2 of the human plasma membrane Ca2+-ATPase 显示文摘 | Hilfiker H Guerini D Carafoli E | 1994 | J Biol Chem1994，269，26： | 1 |
| 12 | Acidic phospholipids, unsaturated fatty acids, and limited proteolysis mimic the effect of calmodulin on the purified erythrocyte Ca2+-ATPase 显示文摘 | Niggli V Adunyah ES Carafoli E | 1981 | J Biol Chem1981，256，： | 1 |
| 13 | Membrane transport in the cellular homeosta-sis of calcium 显示文摘 | Carafoli E | 1986 | Cardiovase Pharmacol1986，，8： | 1 |
| 14 | Specific structural determinants are responsible for the an fioxidant activity and the cell cycle effects of resveratrol 显示文摘 | Stivala L A Savio M Carafoli F | 2001 | Biol Chem2001，276，22： | 1 |
| 15 | Tissue distribution of the four gene products of the plasma membrane Ca^2+ pump 显示文摘 | Thomas P Danilo Guerlni Ernesto Carafoli | 1995 | J Biol Chem1995，270，12： | 1 |
| 16 | Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol显示文摘 | Stivala L A Savio M Carafoli F | 2001 | J Biol Chem2001，276，22： | 1 |
| 17 | Calpain:a protease in search for a function? 显示文摘 | CARAFOLI E MOLINARI M | 1998 | Biochem Biphy Res Common1998，247，3： | 1 |
| 18 | Exporting calcium from cells显示文摘 | Carafoli E Guerini D Coletto L | | 0，，： | 1 |
| 19 | Calcium pumps in health and disease显示文摘 | Brini M Carafoli E | | 0，，04： | 1 |
| 20 | Spe- cific Structural Determinants Are Responsible for the Antioxidant Activity and the Cell Cycle Effects of Res- veratrol显示文摘 | STIVALA L A SAVIO M CARAFOLI F | 2001 | Journal of Biological Chemistry2001，276，22： | 1 |
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