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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Lactobacilli,bifi dobacteria and E.coli nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells显示文摘AIM: To investigate whether the stimulation of peripher- al blood mononuclear cells (PBMNC) with the cell debris and cell extraction of different probiotic strains is similar or species specifi c. METHODS: Three strains of bifi dobacteria, 4 strains of lactobacilli, and E. coli nissle were sonicated and centri- fuged in order to divide them into cell extract and cell debris. PBMNC were separated by density gradient and incubated for 36 h with either the cell debris or the cell extract of single strains of probiotic bacteria in doses from 102 to 108 CFU/mL. Cell supernatants were taken and interleukin (IL)-10, IL-1β, and tumor necosis factor (TNF)-α were determined by ELISA. RESULTS: Depending on the species super-family, the strains had different stimulation patterns. Except for both L. casei strains, the cell extract of bifidobacteriaand lactobacilli had less stimulating capacity than cell debris, whereas the cell extract of E. coli nissle had simi- lar stimulating properties to that of the cell debris of the strain and significantly more stimulating capacity than that of bifi dobacteria and lactobacilli. The cell debris of bifi dobacteria stimulated more cytokine release than the cell debris of lactobacilli. The cell debris of lactobacilli did not have a stimulating capacity when lower concentra- tions were used. Neither cell extraction nor cell debris had an inhibitory effect on the production of the tested cytokines by stimulated PBMNC. CONCLUSION: The incubation of probiotic strains, which have been used in clinical trials for inflammatory diseases, with immunocompetent cells leads to different species specifi c reactions. High IL-10 response to cell de- bris of bifi dobacteria and E. coli nissle can be found. This corresponds to positive effects of bifi dobacteria and E. coli nissle in clinical trials for inflammatory bowel disease compared to negative outcomes obtained with lactoba- cilli. | Ulf Helwig Karen M Lammers Fernando Rizzello Patricia Brigidi Verena Rohleder Elisabetta Caramelli Paolo Giochetti Juergen Schrezenmeir Ulrich R Foelsch Stefan Schreiber Massimo Campieri | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 3 | Performance in Luna's fist-edge-palm test according to educational Ievel显示文摘 | Nitrini R Caramelli P Herrera E Jr | 2005 | Cogn Behav Neurol2005，18，4： | 1 |
| 4 | Impact of ob- structive sleep apnea on cognitive performance 显示文摘 | Bawden FC Oliveira CA Caramelli P | 2011 | Arq Neuropsiquiatr2011，69，4： | 1 |
| 5 | Prevalence of potentially rev ersible dementia outpatient clinic of a terliary university-affiliated hospital in Brazil显示文摘 | Takada LT Caramelli P Radanovic M | 2003 | Arg Neuropsiauiatr2003，61，4： | 1 |
| 6 | Impact of obstructive sleep apnea on cognitive performance 显示文摘 | Bawden FC Oliveira CA Caramelli P | 2011 | Arq Neuropsiquiatr2011，69，4： | 1 |
| 7 | Ability and fitness to driveof Parkinson's disease patients显示文摘 | Borromei A Caramelli R Chieregatti G | 1999 | Funct Neurol1999，14，4： | 1 |
| 8 | Impact of obstructivesleep apnea on cognitive performance显示文摘 | Bawden FC Oliveira CA Caramelli P | 2011 | Arq Neuropsiquiatr2011，69，4： | 1 |
| 9 | The assess- ment and management of pain in the demented and non- demented elderly patient显示文摘 | Andrade D C Faria J W Caramelli P | 2011 | Arq Neuropsiquiatr2011，69，2： | 1 |
| 10 | Prion Diseases, Current Understanding of Epidemiology and Pathogenesis, and Therapeutic Advances显示文摘 | Caramelli M Ru G Acutis P | 2006 | CNS Drugs2006，20，： | 1 |
| 11 | Wilson' disease:MRI with clinical correlation 显示文摘 | Magalhaes ACA Caramelli PC Menezes JR | 1994 | Neuroradiology1994，36，1： | 1 |
| 12 | Performance of peripheral(serum and molecular) blood markers for diagnosis of endometriosis显示文摘 | Mabrouk M Elmakky A Caramelli E | 2012 | Arch Gynecol Obstet2012，285，5： | 1 |
| 13 | Validation of the Brazilian version of the quality of life scale for patients with Alzheimer' s disease (QOL-AD) and their caregivers显示文摘 | Novelli MMPC Nitrini R Caramelli P | | 0，，05： | 1 |
| 14 | Epidemiologic survey of dementia in a community-dwelling Brazilian population显示文摘 | Herrera E Jr Caramelli P Silveira AS | 2002 | Alzheimer Dis Assoc Disord2002，16，2： | 1 |
| 15 | Genetic analysis of the skeletal remains attributed to Francesco Petrarca显示文摘 | Caramelli D Lalueza-Fox C Capelli C | 2007 | Forensic Sci Int2007，173，： | 1 |
| 16 | The origin of European cattle:Evidence from modern and ancient DNA显示文摘 | Caramelli D Lalueza-Fox C | 2006 | Proc Natl Acad Sci USA2006，103，21： | 1 |
| 17 | Suggestions for utilization of the mini-mental state examination in Brazil显示文摘 | Brucki SMD Nitrini R Caramelli P | 2003 | Arq Neuropsiquiatr2003，61，3： | 1 |
| 18 | Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells显示文摘 | Karen Manon Lammers Patrizia Brigidi Beatrice Vitali Paolo Gionchetti Fernando Rizzello Elisabetta Caramelli Diego Matteuzzi Massimo Campieri | 2003 | FEMS Immunology and Medical Microbiology2003，，2： | 1 |
| 19 | Performance of peripheral(serum and molecular)blood markers for diagnosis of endometriosis显示文摘 | Mabrouk M Elmakky A Caramelli E | 2012 | Arch Gynecol Obstet2012，285，： | 1 |
| 20 | Prion diseases:current understanding of epidemiology and pathogenesis,and therapeutic advances显示文摘 | Caramelli M Ru G Acutis P | 2006 | CNS Drugs2006，20，1： | 1 |
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