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| 1 | Biomarkers of hypoxic-ischemic encephalopathy:a systematic review显示文摘Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early hours lack objective measurement tools.Therefore,this systematic review aims to identify putative molecules that can be used in diagnosis in daily clinical practice(PROSPERO ID:CRD42021272610).Data sources Searches were performed in PubMed,Web of Science,and Science Direct databases until November 2020.English original papers analyzing samples from newborns>36 weeks that met at least two American College of Obstetricians and Gynecologists diagnostic criteria and/or imaging evidence of cerebral damage were included.Bias was assessed by the Newcastle–Ottawa Scale.The search and data extraction were verified by two authors separately.Results From 373 papers,30 met the inclusion criteria.Data from samples collected in the first 72 hours were extracted,and increased serum levels of neuron-specific enolase and S100-calcium-binding protein-B were associated with a worse prognosis in newborns that suffered an episode of perinatal asphyxia.In addition,the levels of glial fibrillary acidic protein,ubiquitin carboxyl terminal hydrolase isozyme-L1,glutamic pyruvic transaminase-2,lactate,and glucose were elevated in newborns diagnosed with hypoxic–ischemic encephalopathy.Moreover,pathway analysis revealed insulin-like growth factor signaling and alanine,aspartate and glutamate metabolism to be involved in the early molecular response to insult.Conclusions Neuron-specific enolase and S100-calcium-binding protein-B are potential biomarkers,since they are correlated with an unfavorable outcome of hypoxic-ischemic encephalopathy newborns.However,more studies are required to determine the sensitivity and specificity of this approach to be validated for clinical practice. | Ines Caramelo Margarida Coelho Miguel Rosado Carla M.P.Cardoso Alexandra Dinis Carlos B.Duarte Mario Graos Bruno Manadas | 2023 | World Journal of Pediatrics2023，19，6： | 2 |
| 2 | Getting in and out from calnexin/ calreticulin cycles 显示文摘 | Caramelo J J Parodi A J | 2008 | Journal of Biological Chemistry2008，283，16： | 1 |
| 3 | Mechanism of vascular smooth muscle cells activation by hydrogen peroxide: role of phospholipase C gamma 显示文摘 | Gonzalez Pacheco FR Caramelo C Castilla MA | 2002 | Nephrol Dial Transplant2002，17，3： | 1 |
| 4 | Role of vascular endothelial factor in the reponse to vessel injury 显示文摘 | Avarez Arroyo M V Caramelo C Castilla M A | 1998 | Kidney Int1998，54，1： | 1 |
| 5 | Molecular analysis of hepatitis B virus DNA in serum and peripheral blood mononuclear cells from hepatitis B surface antigen-negative caces显示文摘 | Cabrerizo M Bartolom J Caramelo C | 2000 | Hepatology2000，32，1： | 1 |
| 6 | Anemia in heart failure显示文摘 | Caramelo C Justo S | 2007 | Rev Esp Cardiol2007，60，： | 1 |
| 7 | Role of vascular endothelial growth factor in the response to vessel injury显示文摘 | Alvarez Arroyo MV Caramelo C Angeles Castilla M | | 0，，： | 1 |
| 8 | Role of endothelial growth factor(VEGF) in endothelial cell protection against cytotoxic agents显示文摘 | Castilla MA Caramelo C Gazapo RM | 2000 | Life Sci2000，67，8： | 1 |
| 9 | C-terminal parathyroid hormone-related protein increases vascular endothelial growth factor in human osteoblastic cells 显示文摘 | Esbrit P Alvarez-Arroyo MV Caramelo C | 2000 | J Am Soc Nephrol2000，11，6： | 1 |
| 10 | Molecular analysis of hepatitis B virus DNA in serum and peripheral blood mononuclear cells from hepatitis B surface antigen - negative cases显示文摘 | Cabrerizo M Bartolom inverted question marke J Caramelo C | 2000 | Hepatology2000，32，1： | 1 |
| 11 | Role of vascular endothelial growth factor (VEGF) in endothelial cell protection against cytotoxic agents 显示文摘 | Castilla MA Caramelo C Gazapo RM | 2000 | Life Science2000，67，9： | 1 |
| 12 | Molec- ular analysis of hepatitis B virus DNA in serum and peripheral blood mononuclear cells from hepatitis B surface antigen -neg- ative cases 显示文摘 | CABRERIZO M BARTOLOME J CARAMELO C | 2000 | Hepatology2000，32，1： | 1 |
| 13 | Anemia in heart failure显示文摘 | Caramelo C Justo S | 2007 | Rev Esp Cardiol2007，60，8： | 1 |
| 14 | Role of nitric oxide in autocrine control of growth and apoptosis of endothelial cells显示文摘 | Lopez-Farre A Sanchez de Miguel L Caramelo C | 1997 | Am J Physiol1997，272，22： | 1 |
| 15 | Anisaldchyde production and oxidaae and dchydrogen activities in Ligniolytic fungi of genes plcuetus显示文摘 | Guvicrrex Caramelo L Prieta A | 1994 | Appl Environ Microhiol1994，60，6： | 1 |
| 16 | ANF inhibits vassopressin- induced Ca^2+ mobilization and contraction in glomerular mesangial cells显示文摘 | MEGER L H TSAI P CARAMELO C | 1988 | Am J Physiol1988，255，： | 1 |
| 17 | Role of endothelial growth factor(VEGF) in endothelial cell protection against cytotocic agents 显示文摘 | Castilla MA Caramelo C Gazapo RM | 2000 | Life Sciences2000，67，： | 1 |
| 18 | Cholesterol embolism evaluated by polarized light microscopy after primary renal artery stent placement with filter protection显示文摘 | Urbane J Manzarbetia F Caramelo C | 2008 | J Vasc Interv Radiol2008，19，21： | 1 |
| 19 | Molecular anakysis of hepatitis B virus DNA in serum and peripheral blood mononuclear cells from hepatitis B surface antigen-negative cases显示文摘 | Cabrerizo M Bartolome J Caramelo C | 2000 | Hepatology2000，27，1： | 1 |
| 20 | A sweet code for glycopro- tein folding显示文摘 | CARAMELO J J PARODI A J | 2015 | Febs Letters2015，589，22： | 1 |
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